384 research outputs found
Genome characterization and population genetic structure of the zoonotic pathogen, streptococcus canis
Background - Streptococcus canis is an important opportunistic pathogen of dogs and cats that can also infect a wide range of additional mammals including cows where it can cause mastitis. It is also an emerging human pathogen.
Results - Here we provide characterization of the first genome sequence for this species, strain FSL S3-227 (milk isolate from a cow with an intra-mammary infection). A diverse array of putative virulence factors was encoded by the S. canis FSL S3-227 genome. Approximately 75% of these gene sequences were homologous to known Streptococcal virulence factors involved in invasion, evasion, and colonization. Present in the genome are multiple potentially mobile genetic elements (MGEs) [plasmid, phage, integrative conjugative element (ICE)] and comparison to other species provided convincing evidence for lateral gene transfer (LGT) between S. canis and two additional bovine mastitis causing pathogens (Streptococcus agalactiae, and Streptococcus dysgalactiae subsp. dysgalactiae), with this transfer possibly contributing to host adaptation. Population structure among isolates obtained from Europe and USA [bovine = 56, canine = 26, and feline = 1] was explored. Ribotyping of all isolates and multi locus sequence typing (MLST) of a subset of the isolates (n = 45) detected significant differentiation between bovine and canine isolates (Fisher exact test: P = 0.0000 [ribotypes], P = 0.0030 [sequence types]), suggesting possible host adaptation of some genotypes. Concurrently, the ancestral clonal complex (54% of isolates) occurred in many tissue types, all hosts, and all geographic locations suggesting the possibility of a wide and diverse niche.
Conclusion - This study provides evidence highlighting the importance of LGT in the evolution of the bacteria S. canis, specifically, its possible role in host adaptation and acquisition of virulence factors. Furthermore, recent LGT detected between S. canis and human bacteria (Streptococcus urinalis) is cause for concern, as it highlights the possibility for continued acquisition of human virulence factors for this emerging zoonotic pathogen
A capacitance spectroscopy-based platform for realizing gate-defined electronic lattices
Electrostatic confinement in semiconductors provides a flexible platform for
the emulation of interacting electrons in a two-dimensional lattice, including
in the presence of gauge fields. This combination offers the potential to
realize a wide host of quantum phases. Here we present a measurement and
fabrication scheme that builds on capacitance spectroscopy and allows for the
independent control of density and periodic potential strength imposed on a
two-dimensional electron gas. We characterize disorder levels and
(in)homogeneity and develop and optimize different gating strategies at length
scales where interactions are expected to be strong. A continuation of these
ideas might see to fruition the emulation of interaction-driven Mott
transitions or Hofstadter butterfly physics
Flavor Ratios of Astrophysical Neutrinos: Implications for Precision Measurements
We discuss flavor-mixing probabilities and flavor ratios of high energy
astrophysical neutrinos. In the first part of this paper, we expand the
neutrino flavor-fluxes in terms of the small parameters U_{e3} and pi/4 -
theta_{23}, and show that there are universal first and second order
corrections. The second order term can exceed the first order term, and so
should be included in any analytic study. We also investigate the probabilities
and ratios after a further expansion around the tribimaximal value of sin^2
theta_{12} = 1/3. In the second part of the paper, we discuss implications of
deviations of initial flavor ratios from the usually assumed, idealized flavor
compositions for pion, muon-damped, and neutron beam sources, viz., (1 : 2 :
0), (0 : 1 : 0), and (1 : 0 : 0), respectively. We show that even small
deviations have significant consequences for the observed flavor ratios at
Earth. If initial flavor deviations are not taken into account in analyses,
then false inferences for the values in the PMNS matrix elements (angles and
phase) may result.Comment: 32 pages, 15 figures. Minor changes, matches version in JHE
Simulated-tempering approach to spin-glass simulations
After developing an appropriate iteration procedure for the determination of
the parameters, the method of simulated tempering has been successfully applied
to the 2D Ising spin glass. The reduction of the slowing down is comparable to
that of the multicanonical algorithm. Simulated tempering has, however, the
advantages to allow full vectorization of the programs and to provide the
canonical ensemble directly.Comment: 12 pages (LaTeX), 4 postscript figures, uufiles encoded, submitted to
Physical Review
Large and Almost Maximal Neutrino Mixing within the Type II See-Saw Mechanism
Within the type II see-saw mechanism the light neutrino mass matrix is given
by a sum of a direct (or triplet) mass term and the conventional (type I)
see-saw term. Both versions of the see-saw mechanism explain naturally small
neutrino masses, but the type II scenario offers interesting additional
possibilities to explain large or almost maximal or vanishing mixings which are
discussed in this paper. We first introduce ``type II enhancement'' of neutrino
mixing, where moderate cancellations between the two terms can lead to large
neutrino mixing even if all individual mass matrices and terms generate small
mixing. However, nearly maximal or vanishing mixings are not naturally
explained in this way, unless there is a certain initial structure (symmetry)
which enforces certain elements of the matrices to be identical or related in a
special way. We therefore assume that the leading structure of the neutrino
mass matrix is the triplet term and corresponds to zero U_{e3} and maximal
theta_{23}. Small but necessary corrections are generated by the conventional
see-saw term. Then we assume that one of the two terms corresponds to an
extreme mixing scenario, such as bimaximal or tri-bimaximal mixing. Deviations
from this scheme are introduced by the second term. One can mimic Quark-Lepton
Complementarity in this way. Finally, we note that the neutrino mass matrix for
tri-bimaximal mixing can be -- depending on the mass hierarchy -- written as a
sum of two terms with simple structure. Their origin could be the two terms of
type II see-saw.Comment: 25 pages. Comments and references added, to appear in JHE
Leptogenesis and low energy observables in left-right symmetric models
In the context of left-right symmetric models we study the connection of
leptogenesis and low energy parameters such as neutrinoless double beta decay
and leptonic CP violation. Upon imposition of a unitarity constraint, the
neutrino parameters are significantly restricted and the Majorana phases are
determined within a narrow range, depending on the kind of solar solution. One
of the Majorana phases gets determined to a good accuracy and thereby the
second phase can be probed from the results of neutrinoless double beta decay
experiments. We examine the contributions of the solar and atmospheric mass
squared differences to the asymmetry and find that in general the solar scale
dominates. In order to let the atmospheric scale dominate, some finetuning
between one of the Majorana phases and the Dirac CP phase is required. In this
case, one of the Majorana phases is determined by the amount of CP violation in
oscillation experiments.Comment: 18 pages, 6 figures. Matches version to appear in PR
The Free Quon Gas Suffers Gibbs' Paradox
We consider the Statistical Mechanics of systems of particles satisfying the
-commutation relations recently proposed by Greenberg and others. We show
that although the commutation relations approach Bose (resp.\ Fermi) relations
for (resp.\ ), the partition functions of free gases are
independent of in the range . The partition functions exhibit
Gibbs' Paradox in the same way as a classical gas without a correction factor
for the statistical weight of the -particle phase space, i.e.\ the
Statistical Mechanics does not describe a material for which entropy, free
energy, and particle number are extensive thermodynamical quantities.Comment: number-of-pages, LaTeX with REVTE
Minimal Mass Matrices for Dirac Neutrinos
We consider the possibility of neutrinos being Dirac particles and study
minimal mass matrices with as much zero entries as possible. We find that up to
5 zero entries are allowed. Those matrices predict one vanishing mass state, CP
conservation and U_{e3} either zero or proportional to R, where R is the ratio
of the solar and atmospheric \Delta m^2. Matrices containing 4 zeros can be
classified in categories predicting U_{e3} = 0, U_{e3} \neq 0 but no CP
violation or |U_{e3}| \neq 0 and possible CP violation. Some cases allow to set
constraints on the neutrino masses. The characteristic value of U_{e3} capable
of distinguishing some of the cases with non-trivial phenomenological
consequences is about R/2 \sin 2 \theta_{12}. Matrices containing 3 and less
zero entries imply (with a few exceptions) no correlation for the observables.
We outline models leading to the textures based on the Froggatt-Nielsen
mechanism or the non-Abelian discrete symmetry D_4 \times Z_2.Comment: 32 pages, 3 figures. Comments and references added. To appear in JHE
Linear Collider Test of a Neutrinoless Double Beta Decay Mechanism in left-right Symmetric Theories
There are various diagrams leading to neutrinoless double beta decay in
left-right symmetric theories based on the gauge group SU(2)_L x SU(2)_R. All
can in principle be tested at a linear collider running in electron-electron
mode. We argue that the so-called lambda-diagram is the most promising one.
Taking the current limit on this diagram from double beta decay experiments, we
evaluate the relevant cross section e e to W_L W_R, where W_L is the Standard
Model W-boson and W_R the one from SU(2)_R. It is observable if the life-time
of double beta decay and the mass of the W_R are close to current limits. Beam
polarization effects and the high-energy behaviour of the cross section are
also analyzed.Comment: 17 pages, 6 figures. v2: minor changes, references added, to be
published in EPJ
Search for Doubly-Charged Higgs Boson Production at HERA
A search for the single production of doubly-charged Higgs bosons H^{\pm \pm}
in ep collisions is presented. The signal is searched for via the Higgs decays
into a high mass pair of same charge leptons, one of them being an electron.
The analysis uses up to 118 pb^{-1} of ep data collected by the H1 experiment
at HERA. No evidence for doubly-charged Higgs production is observed and mass
dependent upper limits are derived on the Yukawa couplings h_{el} of the Higgs
boson to an electron-lepton pair. Assuming that the doubly-charged Higgs only
decays into an electron and a muon via a coupling of electromagnetic strength
h_{e \mu} = \sqrt{4 \pi \alpha_{em}} = 0.3, a lower limit of 141 GeV on the
H^{\pm\pm} mass is obtained at the 95% confidence level. For a doubly-charged
Higgs decaying only into an electron and a tau and a coupling h_{e\tau} = 0.3,
masses below 112 GeV are ruled out.Comment: 15 pages, 3 figures, 1 tabl
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