1,165 research outputs found
Editorial overview: Relational values: what are they, and what's the fuss about?
Relational values as preferences, principles and virtues about human-nature relationships have attracted a great deal of attention in recent years. The term has been used to include concepts and knowledge from a wide range of social sciences and humanities, e.g., importantly making space for qualitative approaches often neglected within environmental management and science. Meanwhile, crucial questions have emerged. What counts as a relational value, and what does not? How do relational values (RVs) compare with other value categories and terms, including held, assigned, instrumental, moral, shared, social, and non-material values (e.g., associated with cultural ecosystem services)? In this article, we address these issues, partly by providing context about how the RV term originated and how it has evolved to date. Most importantly, because of their somewhat unique combination of groundedness and moral relevance, positive relational values may offer important opportunities for the evolution of values that may be necessary for transformative change towards sustainability. The special issue includes contributions that contemplate particular concepts (e.g., care, stewardship, eudaimonia human flourishing), applications (e.g., environmental assessment, environmental policy design), and the history of relevant scholarship in various intellectual traditions (e.g., ecological economics, human ecology, environmental education). Together with this suite of thought-provoking papers, we hope that the clarification we provide here facilitates a broad and productive interdisciplinary exchange to create and refine a reflective but powerful tool for sustainability and justice. © 2018We have been funded by a Canadian SSHRC Insight Grant (#435-2017-1071) and a UBC Killam Research Fellowship (KC)
Lagrangian bias in the local bias model
It is often assumed that the halo-patch fluctuation field can be written as a
Taylor series in the initial Lagrangian dark matter density fluctuation field.
We show that if this Lagrangian bias is local, and the initial conditions are
Gaussian, then the two-point cross-correlation between halos and mass should be
linearly proportional to the mass-mass auto-correlation function. This
statement is exact and valid on all scales; there are no higher order
contributions, e.g., from terms proportional to products or convolutions of
two-point functions, which one might have thought would appear upon truncating
the Taylor series of the halo bias function. In addition, the auto-correlation
function of locally biased tracers can be written as a Taylor series in the
auto-correlation function of the mass; there are no terms involving, e.g.,
derivatives or convolutions. Moreover, although the leading order coefficient,
the linear bias factor of the auto-correlation function is just the square of
that for the cross-correlation, it is the same as that obtained from expanding
the mean number of halos as a function of the local density only in the
large-scale limit. In principle, these relations allow simple tests of whether
or not halo bias is indeed local in Lagrangian space. We discuss why things are
more complicated in practice. We also discuss our results in light of recent
work on the renormalizability of halo bias, demonstrating that it is better to
renormalize than not. We use the Lognormal model to illustrate many of our
findings.Comment: 14 pages, published on JCA
Design of photonic crystal optical waveguides with singlemode propagation in the photonic bandgap
Newtonian versus relativistic nonlinear cosmology
Both for the background world model and its linear perturbations Newtonian
cosmology coincides with the zero-pressure limits of relativistic cosmology.
However, such successes in Newtonian cosmology are not purely based on Newton's
gravity, but are rather guided ones by previously known results in Einstein's
theory. The action-at-a-distance nature of Newton's gravity requires further
verification from Einstein's theory for its use in the large-scale nonlinear
regimes. We study the domain of validity of the Newtonian cosmology by
investigating weakly nonlinear regimes in relativistic cosmology assuming a
zero-pressure and irrotational fluid. We show that, first, if we ignore the
coupling with gravitational waves the Newtonian cosmology is exactly valid even
to the second order in perturbation. Second, the pure relativistic correction
terms start appearing from the third order. Third, the correction terms are
independent of the horizon scale and are quite small in the large-scale near
the horizon. These conclusions are based on our special (and proper) choice of
variables and gauge conditions. In a complementary situation where the system
is weakly relativistic but fully nonlinear (thus, far inside the horizon) we
can employ the post-Newtonian approximation. We also show that in the
large-scale structures the post-Newtonian effects are quite small. As a
consequence, now we can rely on the Newtonian gravity in analyzing the
evolution of nonlinear large-scale structures even near the horizon volume.Comment: 8 pages, no figur
Collaborative dynamic decision making: a case study from B2B supplier selection
The problem of supplier selection can be easily modeled as a multiple-criteria decision making (MCDM) problem: businesses express their preferences with respect to suppliers, which can then be ranked and selected. This approach has two major pitfalls: first, it does not consider a dynamic scenario, in which suppliers and their ratings are constantly changing; second, it only addressed the problem from the point of view of a single business, and cannot be easily applied when considering more than one business. To overcome these problems, we introduce a method for supplier selection that builds upon the dynamic MCDM framework of Campanella and Ribeiro [1] and, by means of a linear programming model, can be used in the case of multiple collaborating businesses plan- ning their next batch of orders together.Fundação para a Ciência e a Tecnologia, Portugal, under contract CONT DOUT/49/UNINOVA/0/5902/1/200
The Sachs-Wolfe Effect: Gauge Independence and a General Expression
In this paper we address two points concerning the Sachs-Wolfe effect: (i)
the gauge independence of the observable temperature anisotropy, and (ii) a
gauge-invariant expression of the effect considering the most general situation
of hydrodynamic perturbations. The first result follows because the gauge
transformation of the temperature fluctuation at the observation event only
contributes to the isotropic temperature change which, in practice, is absorbed
into the definition of the background temperature. Thus, we proceed without
fixing the gauge condition, and express the Sachs-Wolfe effect using the
gauge-invariant variables.Comment: 5 pages, closer to published versio
Gauge-ready formulation of the cosmological kinetic theory in generalized gravity theories
We present cosmological perturbations of kinetic components based on
relativistic Boltzmann equations in the context of generalized gravity
theories. Our general theory considers an arbitrary number of scalar fields
generally coupled with the gravity, an arbitrary number of mutually interacting
hydrodynamic fluids, and components described by the relativistic Boltzmann
equations like massive/massless collisionless particles and the photon with the
accompanying polarizations. We also include direct interactions among fluids
and fields. The background FLRW model includes the general spatial curvature
and the cosmological constant. We consider three different types of
perturbations, and all the scalar-type perturbation equations are arranged in a
gauge-ready form so that one can implement easily the convenient gauge
conditions depending on the situation. In the numerical calculation of the
Boltzmann equations we have implemented four different gauge conditions in a
gauge-ready manner where two of them are new. By comparing solutions solved
separately in different gauge conditions we can naturally check the numerical
accuracy.Comment: 26 pages, 9 figures, revised thoroughly, to appear in Phys. Rev.
Design, synthesis and SAR exploration of tri-substituted 1,2,4-triazoles as inhibitors of the annexin A2–S100A10 protein interaction
Recent target validation studies have shown that inhibition of the protein interaction between annexin A2 and the S100A10 protein may have potential therapeutic benefits in cancer. Virtual screening identified certain 3,4,5-trisubstituted 4H-1,2,4-triazoles as moderately potent inhibitors of this interaction. A series of analogues were synthesized based on the 1,2,4-triazole scaffold and were evaluated for inhibition of the annexin A2–S100A10 protein interaction in competitive binding assays. 2-[(5-{[(4,6-Dimethylpyrimidin-2-yl)sulfanyl]methyl}-4-(furan-2-ylmethyl)-4H-1,2,4-triazol-3-yl)sulfanyl]-N-[4-(propan-2-yl)phenyl]acetamide (36) showed improved potency and was shown to disrupt the native complex between annexin A2 and S100A10
Dynamic mechanical thermal analysis of aqueous sugar solutions containing fructose, glucose, sucrose, maltose and lactose
The glass transition of glucose, fructose, lactose, maltose and sucrose solutions at maximum cryo-concentration was studied by Dynamic Mechanical Thermal Analysis (DMTA), using the disc bending technique. The glass transition temperatures were determined from the peaks in the loss modulus E′′, which corresponds theoretically to the resonance point (Maxwell model) for several input frequencies. The frequency dependence was well described by both an Arrhenius-type model and by the WLF (Williams, Landel and Ferry) equation, yielding glass transition temperatures for an average molecular vibration time of 100 s, which were similar to published midpoint temperatures determined by DSC scans. Some sugar mixtures were studied, yielding results that were well described by the Gordon–Taylor equation, using literature data. The frequency dependence of the viscoelastic ratio was also well approximated by an Arrhenius-type equation, with activation energies similar to those of the glass transition temperature and corresponded well to published values of the endset of glass transition
Knowledge-based energy functions for computational studies of proteins
This chapter discusses theoretical framework and methods for developing
knowledge-based potential functions essential for protein structure prediction,
protein-protein interaction, and protein sequence design. We discuss in some
details about the Miyazawa-Jernigan contact statistical potential,
distance-dependent statistical potentials, as well as geometric statistical
potentials. We also describe a geometric model for developing both linear and
non-linear potential functions by optimization. Applications of knowledge-based
potential functions in protein-decoy discrimination, in protein-protein
interactions, and in protein design are then described. Several issues of
knowledge-based potential functions are finally discussed.Comment: 57 pages, 6 figures. To be published in a book by Springe
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