A study to examine the operation and function of a virtual UK environmental specimen bank (UK-ESB). Final report

Executive Summary: 1. Environmental specimen banking is recognised internationally as an integral part of long-term environmental research and monitoring. Analysis of preserved environmental samples is often needed to detect and quantify patterns and rate of environmental change, and the emergence and progression of environmental hazards and risks. 2. National Environmental Specimen Banks have been established in several countries; they vary in scope and breadth. There are a few specialised environmental specimen holdings in the UK but no national-scale catalogue of holdings, despite an estimated annual spend of £16 million to store specimens. This lack of information results in under-exploitation of archived specimens and is a lost opportunity to facilitate world-class science and identify emerging pressures and threats on the environment. 3. An earlier project had identified key stakeholder organisations either engaged in archiving nationally important environmental specimens or who wished to utilise such specimens. These stakeholders had agreed there was a need for a national metadata catalogue of environmental specimens (subsequently termed a virtual UK-ESB). The objective of the current project was to further develop a virtual UK-ESB. Specifically, the aim was to work with stakeholders to establish the correct metadata entry fields, the search capabilities, the functionality and the nature of the hosting website of a virtual UK-ESB. 4. More than 80 stakeholder organisations that had previously expressed an interest in a UK-ESB were approached to provide feedback either electronically or by attending a stakeholder workshop. Thirty eight organisations responded. All remained interested in the UK-ESB concept and seventeen answered the survey questions. 5. Mock-ups of data entry screens, search screens and ideas around the functionality of a UK-ESB were developed by the CEH project team. These were mailed to stakeholders for feedback. Initial feedback was incorporated into the mock-ups which were then presented for discussion at a workshop comprising 15 attendees from across the specimen archiving community, CEH and the UK-EOF. 6. Workshop participants reviewed and agreed the format of 23 mandatory or optional data-entry fields for a virtual UK-ESB that, in the absence of standard for material samples and archives, were aligned with ISO19115 (geospatial metadata standard) and DublinCore (metadata standard). These fields were sub-divided into the following headings: Sample description, Categorisation, keywords and links, Storage Information and Contact information. Workshop participants also made a number of recommendations as to the format of the data entry screens and inclusion of extra fields. 7. Workshop participants reviewed options for search capabilities and made recommendations as to simple and advanced searching methods and their formats. It was also recommended that search facilities of the ESBs of other countries be examined to determine what is used, ease of use, and how they match the recommendations from the workshop. 8. Workshop participants reviewed options for functionality and agreed a detailed list of prioritised requirements. 9. Workshop participants agreed that a virtual UK-ESB should be hosted through a dedicated website that would also provide wider information, such as recently updated or added specimen holdings, most downloaded information, links to other groups, standard operating procedures, etc. 10. The next step for the development of a virtual UK-ESB is to implement the design and development ideas captured in the current report and build a test version of a virtual UK-ESB. This would be tested and refined, and could then be launched on a specifically designed website. This would need to be accompanied by a communication strategy. There is potential to link and co-brand a virtual UK-ESB with the UK-Environmental Observation Framework (UK-EOF)

Effects of ion and electron correlations on neutrino scattering in the infall phase of a supernova

Many authors have used one-component plasma simulations in discussing the role of ion-ion correlations in reducing neutrino opacities during the collapse phase of a supernova. In a multicomponent plasma in which constituent ions have even a small range of N/Z ratios neutrino opacities are much larger, in some regions of parameters, than for the case of a one component plasma.Comment: 5 pages. Final version. To be published in Phys. Lett.

Absence of resonant enhancements in some inclusive rates

A toy model is defined and solved perturbatively with the aim of examining some claimed "resonant" enhancements of certain reaction rates that enter popular models of leptogenesis. We find: a) that such enhancements are absent; and b) that the perturbative solution, as done correctly using finite- temperature field theory, is well defined without the "resumming" procedures found in the literature. The pathologies that led to the perceived need for these procedures are an artifact of uncritical use of weighted vacuum cross- sections in the determination of rates, without adequate attention to the effects of the medium upon the single particle states within it.Comment: 11 pages, no figures. Some typos corrected. More typos correcte

Parallel multicentre randomised trial of a clinical trial question prompt list in patients considering participation in phase 3 cancer treatment trials

Accepted 9 February 2017Objective: To evaluate the effect of a clinical trial question prompt list in patients considering enrolment in cancer treatment trials. Setting: Tertiary cancer referral hospitals in three state capital cities in Australia. Participants: 88 patients with cancer attending three cancer centres in Australia, who were considering enrolment in phase 3 treatment trials, were invited to enrol in an unblinded randomised trial of provision of a clinical trial question prompt list (QPL) before consenting to enrol in the treatment trial. Interventions: We developed and pilot tested a targeted QPL for patients with cancer considering clinical trial participation (the clinical trial QPL). Consenting patients were randomised to receive the clinical trial QPL or not before further discussion with their oncologist and/or trial nurse about the treatment trial. Primary and secondary outcomes: Questionnaires were completed at baseline and within 3â €..weeks of deciding on treatment trial participation. Main outcome measure: scores on the Quality of Informed Consent questionnaire (QuIC). Results: 88 patients of 130 sought for the study were enrolled (43 males), and 45 received the clinical trial QPL. 49% of trials were chemotherapy interventions for patients with advanced disease, 35% and 16% were surgical adjuvant and radiation adjuvant trials respectively. 70 patients completed all relevant questionnaires. 28 of 43 patients in the control arm compared with 39 of 45 patients receiving the clinical trial QPL completed the QuIC (p=0.0124). There were no significant differences in the QuIC scores between the randomised groups (QuIC part A p=0.08 and QuIC part B p=0.92). There were no differences in patient satisfaction with decisions or in anxiety levels between the randomised groups. Conclusions: Use of a question prompt list did not significantly change the QuIC scores in this randomised trial. ANZCTR 12606000214538 prospectively registered 31/5/2006. Trial registration number: Results, ACTRN12606000214538.Martin H N Tattersall, Michael Jefford, Andrew Martin, Ian Olver, John F Thompson, Richard F Brown, Phyllis N Buto

A Coupled-Cluster Formulation of Hamiltonian Lattice Field Theory: The Non-Linear Sigma Model

We apply the coupled cluster method (CCM) to the Hamiltonian version of the latticised O(4) non-linear sigma model. The method, which was initially developed for the accurate description of quantum many-body systems, gives rise to two distinct approximation schemes. These approaches are compared with each other as well as with some other Hamiltonian approaches. Our study of both the ground state and collective excitations leads to indications of a possible chiral phase transition as the lattice spacing is varied.Comment: 44 Pages, 14 figures. Uses Latex2e, graphicx, amstex and geometry package

Acoustic Events in the Solar Atmosphere from Hinode/SOT NFI observations

We investigate the properties of acoustic events (AEs), defined as spatially concentrated and short duration energy flux, in the quiet sun using observations of a 2D field of view (FOV) with high spatial and temporal resolution provided by the Solar Optical Telescope (SOT) onboard \textit{Hinode}. Line profiles of Fe \textsc{i} 557.6 nm were recorded by the Narrow band Filter Imager (NFI) on a $82" \times 82"$ FOV during 75 min with a time step of 28.75 s and 0.08$"$ pixel size. Vertical velocities were computed at three atmospheric levels (80, 130 and 180 km) using the bisector technique allowing the determination of energy flux in the range 3-10 mHz using two complementary methods (Hilbert transform and Fourier power spectra). Horizontal velocities were computed using local correlation tracking (LCT) of continuum intensities providing divergences. The net energy flux is upward. In the range 3-10 mHz, a full FOV space and time averaged flux of 2700 W m$^{-2}$ (lower layer 80-130 km) and 2000 W m$^{-2}$ (upper layer 130-180 km) is concentrated in less than 1% of the solar surface in the form of narrow (0.3$"$) AE. Their total duration (including rise and decay) is of the order of $10^{3}$ s. Inside each AE, the mean flux is $1.6 10^{5}$ W m$^{-2}$ (lower layer) and $1.2 10^{5}$ W m$^{-2}$ (upper). Each event carries an average energy (flux integrated over space and time) of $2.5 10^{19}$ J (lower layer) to $1.9 10^{19}$ J (upper). More than $10^{6}$ events could exist permanently on the Sun, with a birth and decay rate of 3500 s$^{-1}$. Most events occur in intergranular lanes, downward velocity regions, and areas of converging motions.Comment: 18 pages, 10 figure

Radiation Reaction: General approach and applications, especially to electrodynamics

Radiation reaction (but, more generally, fluctuations and dissipation) occurs when a system interacts with a heat bath, a particular case being the interaction of an electron with the radiation field. We have developed a general theory for the case of a quantum particle in a general potential (but, in more detail, an oscillator potential) coupled to an arbitrary heat bath at arbitrary temperature, and in an external time-dependent $c$-number field. The results may be applied to a large variety of problems in physics but we concentrate by showing in detail the application to the blackbody radiation heat bath, giving an exact result for radiation reaction problem which has no unsatisfactory features such as the runaway solutions associated with the Abraham-Lorentz theory. In addition, we show how atomic energy and free energy shifts due to temperature may be calculated. Finally, we give a brief review of applications to Josephson junctions, quantum statistical mechanics, mesoscopic physics, quantum information, noise in gravitational wave detectors, Unruh radiation and the violation of the quantum regression theore

Using the NANA toolkit at home to predict older adults' future depression

Background: Depression is currently underdiagnosed among older adults. As part of the Novel Assessment of Nu-trition and Aging (NANA) validation study, 40 older adults self-reported their mood using a touchscreen computer over three, one-week periods. Here, we demonstrate the potential of these data to predict future depression status. Methods: We analysed data from the NANA validation study using a machine learning approach. We applied the least absolute shrinkage and selection operator with a logistic model to averages of six measures of mood, with depression status according to the Geriatric Depression Scale 10 weeks later as the outcome variable. We tested multiple values of the selection parameter in order to produce a model with low deviance. We used a cross-validation framework to avoid overspecialisation, and receiver operating characteristic curve (ROC) analysis to determine the quality of the fitted model. Results: The model we report contained coefficients for two variables: sadness and tiredness, as well as a constant. The cross-validated area under the ROC curve for this model was 0.88 (CI: 0.69–0.97). Limitations: While results are based on a small sample, the methodology for the selection of variables appears suitable for the problem at hand, suggesting promise for a wider study and ultimate deployment with older adults at increased risk of depression. Conclusions: We have identified self-reported scales of sadness and tiredness as sensitive measures which have the potential to predict future depression status in older adults, partially addressing the problem of underdiagnosis

Anomalous Behavior of 2+ Excitations around 132Sn

In certain neutron-rich Te isotopes, a decrease in the energy of the first excited 2+ state is accompanied by a decrease in the E2 strength to that state from the ground state, contradicting simple systematics and general intuition about quadrupole collectivity. We use a separable quadrupole-plus-pairing Hamiltonian and the quasiparticle random phase approximation to calculate energies, B(E2,0+ -> 2+) strengths, and g factors for the lowest 2+ states near 132Sn (Z >= 50). We trace the anomalous behavior in the Te isotopes to a reduced neutron pairing above the N = 82 magic gap.Comment: 1 figure added. to be published in Phys. Rev.