Characterization of Polar Stratospheric Clouds With Spaceborne Lidar: CALIPSO and the 2006 Antarctic Season

The role of polar stratospheric clouds in polar ozone loss has been well documented. The CALIPSO satellite mission offers a new opportunity to characterize PSCs on spatial and temporal scales previously unavailable. A PSC detection algorithm based on a single wavelength threshold approach has been developed for CALIPSO. The method appears to accurately detect PSCs of all opacities, including tenuous clouds, with a very low rate of false positives and few missed clouds. We applied the algorithm to CALIPSO data acquired during the 2006 Antarctic winter season from 13 June through 31 October. The spatial and temporal distribution of CALIPSO PSC observations is illustrated with weekly maps of PSC occurrence. The evolution of the 2006 PSC season is depicted by time series of daily PSC frequency as a function of altitude. Comparisons with virtual solar occultation data indicate that CALIPSO provides a different view of the PSC season than attained with previous solar occultation satellites. Measurement-based time series of PSC areal coverage and vertically-integrated PSC volume are computed from the CALIPSO data. The observed area covered with PSCs is significantly smaller than would be inferred from a temperature-based proxy such as TNAT but is similar in magnitude to that inferred from TSTS. The potential of CALIPSO measurements for investigating PSC microphysics is illustrated using combinations of lidar backscatter coefficient and volume depolarization to infer composition for two CALIPSO PSC scenes

Population genetic analysis of a medicinally significant Australian rainforest tree, Fontainea picrosperma C.T. White (Euphorbiaceae): biogeographic patterns and implications for species domestication and plantation establishment

Background: Fontainea picrosperma, a subcanopy tree endemic to the rainforests of northeastern Australia, is of medicinal significance following the discovery of the novel anti-cancer natural product, EBC-46. Laboratory synthesis of EBC-46 is unlikely to be commercially feasible and consequently production of the molecule is via isolation from F. picrosperma grown in plantations. Successful domestication and plantation production requires an intimate knowledge of a taxon’s life-historyattributes and genetic architecture, not only to ensure the maximum capture of genetic diversity from wild source populations, but also to minimise the risk of a detrimental loss in genetic diversity via founder effects during subsequent breeding programs designed to enhance commercially significant agronomic traits. Results: Here we report the use of eleven microsatellite loci (PIC = 0.429; PID = 1.72 × 10−6 ) to investigate the partitioning of genetic diversity within and among seven natural populations of F. picrosperma. Genetic variation among individuals and within populations was found to be relatively low (A = 2.831; HE = 0.407), although there was marked differentiation among populations (PhiPT = 0.248). Bayesian, UPGMA and principal coordinates analyses detected three main genotypic clusters (K = 3), which were present at all seven populations. Despite low levels of historical gene flow (Nm = 1.382), inbreeding was negligible (F = -0.003); presumably due to the taxon’s dioecious breeding system. Conclusion: The data suggests that F. picrosperma was previously more continuously distributed, but that rainforest contraction and expansion in response to glacial-interglacial cycles, together with significant anthropogenic effects have resulted in significant fragmentation. This research provides important tools to support plantation establishment, selection and genetic improvement of this medicinally significant Australian rainforest species

Differences in Major Histocompatibility Complex Frequencies after Multitrait, Divergent Selection for Immunocompetence

White Leghorn chickens from lines selected for four immune-response traits (IR lines) were serotyped for B system alloantigens characterizing the haplotypes and genotypes to examine the effect of divergent selection for multitrait immunocompetence on MHC haplotype and genotype frequencies. The selected lines were derived from the Ottawa Strain 7. The selection index included four immunocompetence traits: antibody production against Mycoplasma gallisepticum (MG) and Pasteurella multocida, inflammatory response to phytohemagglutinin, and reticuloendothelial carbon clearance. The four lines include two replicates of high and low multitrait-immunocompetence lines. After four cycles of selection, significant differences (P \u3c .05) in several B system haplotype frequencies were observed, both among IR lines and between the IR lines and the Ottawa Strain 7. The B2 haplotype frequency was greater in all IR lines than in the Ottawa Strain 7. The B21 frequency was less in both high lines than in the Ottawa Strain 7. In comparisons among lines, frequencies of B21 were greater in both replicates of the low lines and the B12 and B19 frequencies were significantly greater (P \u3c .05) in the high lines. A gene substitution model showed effects (P \u3c .10) of specific haplotypes on MG and on the index. The B2 haplotype had a positive effect associated with MG. Haplotype B21 was positively associated with the multitrait index. Haplotype B13 had a negative effect on both MG and the index. Significant differences (P \u3c .01) in genotype frequencies were also noted among the IR lines. Associations between specific MHC haplotypes or genotypes and immune-response traits may offer insight into MHC-mediated mechanisms of disease resistance

31064 The Detroit Keloid Scale: A validated tool for rating keloids

Background: No keloid-specific outcome measures exist. Objective: To develop and validate the Detroit Keloid Scale (DKS), a standardized method of keloid assessment to better compare treatments. Methods: Forty-seven physicians were polled to develop the DKS. The scale was validated in 52 patients with keloids against the Vancouver Scar Scale (VSS), Patient and Observer Scar Assessment Scale (POSAS), and Dermatology Life Quality Index (DLQI) by 3 physicians. Results: The interrater reliability was “substantial” for observer component of the DKS and only “moderate” for the VSS and observer POSAS (ICC were 0.80, 0.60, and 0.47, respectively). Pearson’s correlation indicated a “moderate” association between the observer component of DKS with observer component of POSAS (ρ = 0.56, P \u3c.001) and a “substantial” relationship between the observer component of DKS and VSS (ρ = 0.63, P \u3c.001). Pearson’s correlation indicated a “moderate” association between the patient portion of DKS and patient portion of POSAS and the patient portion of the DKS and DLQI (0.61 and 0.60, respectively, P \u3c.05). The DKS total score consistently showed “substantial” relationship with POSAS total score (ρ = 0.65, P \u3c.001). Limitations: Single center study, no intrarater reliability analysis. Conclusions: The substantial interrater reliability of the DKS will allow for improved standardization in future keloid research

Main Field Tracking Measurement in the LHC Superconducting Dipole and Quadrupole Magnets

One of the most stringent requirements during the energy ramp of the Large Hadron Collider (LHC) is to have a constant ratio between dipole-quadrupole and dipole-dipole field so as to control the variation of the betatron tune and of the beam orbit throughout the acceleration phase, hence avoiding particle loss. To achieve the nominal performance of the LHC, a maximum variation of ±0.003 tune units can be tolerated. For the commissioning with low intensity beams, acceptable bounds are up to 30 times higher. For the quadrupole-dipole integrated field ratio, the above requirements translate in the tight windows of 6 ppm and 180 ppm, while for dipole differences between sectors the acceptable error is of the order of 10^-4. Measurement and control at this level are challenging. For this reason we have launched a dedicated measurement R&D to demonstrate that these ratios can be measured and controlled within the limits for machine operation. In this paper we present the techniques developed to power the magnets during the current ramps, the instrumentation and data acquisition setup used to perform the tracking experiments, the calibration procedure and the data reduction employed

A Demonstration Experiment for the Main Field Tracking and the Sextupole and Decapole Compensation in the LHC Main Magnets

A dedicated measurement campaign was set up to test the FiDeL concept and its LSA implementation. The test was performed by demonstrating the tracking of B1 and B2 for two LHC main dipoles and one LHC main quadrupole. It also included the compensation of the b3 and b5 harmonics in the dipole magnets using the sextupole and decapole corrector magnets. In this report we present the techniques developed to power the magnets for these tests during the current ramps; the instrumentation and data acquisition setup used to perform the tracking experiments; the calibration procedure and data corrections employed; and finally the main results obtained

LEP Operation and Performance with 100 GeV Colliding Beams

Luminosity production in LEP was extended to 101 GeV beam energy in 1999 and 104.4 GeV in 2000. The performance was continually optimised, resulting in 1999 peak and integrated luminosities higher than in any previous year of LEP operation. In particular, the beam-beam tune shift reached 0.083 per interaction point. This was achieved with the help of a faster luminosity monitoring, a new tune working point, a reduced design vertical dispersion and new dispersion and coupling optimisation tools. A higher beam rate from the injectors, a better injection efficiency, a faster ramp and a newly automated control of the horizontal damping partition number Jx maximised the time available for physics and thus contributed to the higher integrated luminosity