1,773 research outputs found
High Performance Associative Memories and Structured Weight Dilution
Copyright SpringerThe consequences of two techniques for symmetrically diluting the weights of the standard Hopfield architecture associative memory model, trained using a non-Hebbian learning rule, are examined. This paper reports experimental investigations into the effect of dilution on factors such as: pattern stability and attractor performance. It is concluded that these networks maintain a reasonable level of performance at fairly high dilution rates
The hierarchy of stability and predictability in orthognathic surgery with rigid fixation: an update and extension
A hierarchy of stability exists among the types of surgical movements that are possible with orthognathic surgery. This report updates the hierarchy, focusing on comparison of the stability of procedures when rigid fixation is used. Two procedures not previously placed in the hierarchy now are included: correction of asymmetry is stable with rigid fixation and repositioning of the chin also is very stable. During the first post-surgical year, surgical movements in patients treated for Class II/long face problems tend to be more stable than those treated for Class III problems. Clinically relevant changes (more than 2 mm) occur in a surprisingly large percentage of orthognathic surgery patients from one to five years post-treatment, after surgical healing is complete. During the first post-surgical year, patients treated for Class II/long face problems are more stable than those treated for Class III problems; from one to five years post-treatment, some patients in both groups experience skeletal change, but the Class III patients then are more stable than the Class II/long face patients. Fewer patients exhibit long-term changes in the dental occlusion than skeletal changes, because the dentition usually adapts to the skeletal change
EPITHELIAL-SPECIFIC TRIGGERS OF NEUTROPHILIC INFLAMMATION FOLLOWING HUMAN RHINOVIRUS (HRV) INFECTION IN CHILDREN WITH CYSTIC FIBROSIS (CF)
Trial by fire, water, and soot : Kansas State University's collection disaster plan dissected and what you can learn from our disaster
How would your collection disaster plan fare in a large-scale disaster event? Do you have a plan? Are the major players aware of the plan and their role? In May 2018, Kansas State University's Hale Library experienced a fire which resulted in soot and water damage to all collections. Scale of damage varied widely by location in the building. Come to hear how our disaster plan worked, what we would do again, what we would change and refine moving forward, and how our plan was applied in a large-scale library collection disaster event
Functional characterization of human variants of NFKBIA: a key regulator of immune responsiveness implicated in susceptibility to infectious and inflammatory disease
Rapid size change associated with intra-island evolutionary radiation in extinct Caribbean "island-shrews"
Background: The Caribbean offers a unique opportunity to study evolutionary dynamics in insular mammals. However,
the recent extinction of most Caribbean non-volant mammals has obstructed evolutionary studies, and poor DNA
preservation associated with tropical environments means that very few ancient DNA sequences are available for extinct
vertebrates known from the region’s Holocene subfossil record. The endemic Caribbean eulipotyphlan family
Nesophontidae (“island-shrews”) became extinct ~ 500 years ago, and the taxonomic validity of many Nesophontes species
and their wider evolutionary dynamics remain unclear. Here we use both morphometric and palaeogenomic methods to
clarify the status and evolutionary history of Nesophontes species from Hispaniola, the second-largest Caribbean island.
Results: Principal component analysis of 65 Nesophontes mandibles from late Quaternary fossil sites across Hispaniola
identified three non-overlapping morphometric clusters, providing statistical support for the existence of three sizedifferentiated Hispaniolan Nesophontes species. We were also able to extract and sequence ancient DNA from a ~ 750-yearold specimen of Nesophontes zamicrus, the smallest non-volant Caribbean mammal, including a whole-mitochondrial
genome and partial nuclear genes. Nesophontes paramicrus (39-47 g) and N. zamicrus (~ 10 g) diverged recently during the
Middle Pleistocene (mean estimated divergence = 0.699 Ma), comparable to the youngest species splits in Eulipotyphla and
other mammal groups. Pairwise genetic distance values for N. paramicrus and N. zamicrus based on mitochondrial and
nuclear genes are low, but fall within the range of comparative pairwise data for extant eulipotyphlan species-pairs.
Conclusions: Our combined morphometric and palaeogenomic analyses provide evidence for multiple co-occurring
species and rapid body size evolution in Hispaniolan Nesophontes, in contrast to patterns of genetic and morphometric
differentiation seen in Hispaniola’s extant non-volant land mammals. Different components of Hispaniola’s mammal fauna
have therefore exhibited drastically different rates of morphological evolution. Morphological evolution in Nesophontes is
also rapid compared to patterns across the Eulipotyphla, and our study provides an important new example of rapid body
size change in a small-bodied insular vertebrate lineage. The Caribbean was a hotspot for evolutionary diversification as
well as preserving ancient biodiversity, and studying the surviving representatives of its mammal fauna is insufficient to
reveal the evolutionary patterns and processes that generated regional diversity
Unshifting the baseline: a framework for documenting historical population changes and assessing long-term anthropogenic impacts
Ecological baselines—reference states of species' distributions and abundances—are key to the scientific arguments underpinning many conservation and management interventions, as well as to the public support to such interventions. Yet societal as well as scientific perceptions of these baselines are often based on ecosystems that have been deeply transformed by human actions. Despite increased awareness about the pervasiveness and implications of this shifting baseline syndrome, ongoing global assessments of the state of biodiversity do not take into account the long-term, cumulative, anthropogenic impacts on biodiversity. Here, we propose a new framework for documenting such impacts, by classifying populations according to the extent to which they deviate from a baseline in the absence of human actions. We apply this framework to the bowhead whale (Balaena mysticetus) to illustrate how it can be used to assess populations with different geographies and timelines of known or suspected impacts. Through other examples, we discuss how the framework can be applied to populations for which there is a wide diversity of existing knowledge, by making the best use of the available ecological, historical and archaeological data. Combined across multiple populations, this framework provides a standard for assessing cumulative anthropogenic impacts on biodiversity
Home range and habitat data for Hispaniolan mammals challenge assumptions for conservation management
Conservation decision-making for threatened species in human-modified landscapes requires detailed knowledge about spatial ecology, but robust data derived from tracking individual animals are often unavailable, with management decisions potentially based on unreliable anecdotal data. Existing data are limited for Hispaniola's two threatened non-volant land mammals, the Hispaniolan hutia (Plagiodontia aedium) and Hispaniolan solenodon (Solenodon paradoxus), with assumptions that hutias are better able to tolerate landscape disturbance. We collected spatial behaviour and habitat use data for Hispaniolan mammals during a multi-year field programme across undisturbed and modified habitats in southwestern Dominican Republic, using GPS units for hutias (11 individuals) and radio-telemetry for solenodons (22 individuals). Although significant differences exist in hutia home range estimates between different GPS error derivation strategies and estimated terrestrial/arboreal behaviour scenarios (95% KDE means = 23,582–28,612 m2), hutias almost exclusively use forest under all estimates (mean observations in forest across all strategies/scenarios = 90.3%, total range = 69.1–100%). Solenodons have larger estimated home ranges (95% KDE mean = 156,700 m2), with differences between wet and dry season estimates, and show much more variation in habitat use than hutias within the same landscape; animals regularly use both forested and modified habitats, being observed most frequently in forest (mean = 74.0%, range = 13.0–99.1%) but also occurring regularly in pasture (mean = 15.9%, range = 0–80.0%) and cropland (mean = 7.7%, range = 0–62.0%), and den in all three habitats. This new baseline on Hispaniolan mammal spatial ecology challenges anecdotal data, and suggests solenodons may be better able to tolerate disturbance and persist in modified landscapes
Early Holocene human presence in Madagascar evidenced by exploitation of avian megafauna
Previous research suggests that people first arrived on Madagascar by ~2500 years before present (years B.P.). This hypothesis is consistent with butchery marks on extinct lemur bones from ~2400 years B.P. and perhaps with archaeological evidence of human presence from ~4000 years B.P. We report >10,500-year-old human-modified bones for the extinct elephant birds Aepyornis and Mullerornis, which show perimortem chop marks, cut marks, and depression fractures consistent with immobilization and dismemberment. Our evidence for anthropogenic perimortem modification of directly dated bones represents the earliest indication of humans in Madagascar, predating all other archaeological and genetic evidence by >6000 years and changing our understanding of the history of human colonization of Madagascar. This revision of Madagascar’s prehistory suggests prolonged human-faunal coexistence with limited biodiversity loss
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