816 research outputs found
Multi-mode TES bolometer optimization for the LSPE-SWIPE instrument
In this paper we explore the possibility of using transition edge sensor
(TES) detectors in multi-mode configuration in the focal plane of the Short
Wavelength Instrument for the Polarization Explorer (SWIPE) of the
balloon-borne polarimeter Large Scale Polarization Explorer (LSPE) for the
Cosmic Microwave Background (CMB) polarization. This study is motivated by the
fact that maximizing the sensitivity of TES bolometers, under the augmented
background due to the multi-mode design, requires a non trivial choice of
detector parameters. We evaluate the best parameter combination taking into
account scanning strategy, noise constraints, saturation power and operating
temperature of the cryostat during the flight.Comment: in Journal of Low Temperature Physics, 05 January 201
New radio observations of anomalous microwave emission in the HII region RCW175
We have observed the HII region RCW175 with the 64m Parkes telescope at
8.4GHz and 13.5GHz in total intensity, and at 21.5GHz in both total intensity
and polarization. High angular resolution, high sensitivity, and polarization
capability enable us to perform a detailed study of the different constituents
of the HII region. For the first time, we resolve three distinct regions at
microwave frequencies, two of which are part of the same annular diffuse
structure. Our observations enable us to confirm the presence of anomalous
microwave emission (AME) from RCW175. Fitting the integrated flux density
across the entire region with the currently available spinning dust models,
using physically motivated assumptions, indicates the presence of at least two
spinning dust components: a warm component with a relatively large hydrogen
number density n_H=26.3/cm^3 and a cold component with a hydrogen number
density of n_H=150/cm^3. The present study is an example highlighting the
potential of using high angular-resolution microwave data to break model
parameter degeneracies. Thanks to our spectral coverage and angular resolution,
we have been able to derive one of the first AME maps, at 13.5GHz, showing
clear evidence that the bulk of the AME arises in particular from one of the
source components, with some additional contribution from the diffuse
structure. A cross-correlation analysis with thermal dust emission has shown a
high degree of correlation with one of the regions within RCW175. In the center
of RCW175, we find an average polarized emission at 21.5GHz of
2.2\pm0.2(rand.)\pm0.3(sys.)% of the total emission, where we have included
both systematic and statistical uncertainties at 68% CL. This polarized
emission could be due to sub-dominant synchrotron emission from the region and
is thus consistent with very faint or non-polarized emission associated with
AME.Comment: Accepted for publication in the Astrophysical Journa
Detailed study of the microwave emission of the supernova remnant 3C 396
We have observed the supernova remnant 3C~396 in the microwave region using
the Parkes 64-m telescope. Observations have been made at 8.4 GHz, 13.5 GHz,
and 18.6 GHz and in polarisation at 21.5 GHz. We have used data from several
other observatories, including previously unpublished observations performed by
the Green Bank Telescope at 31.2 GHz, to investigate the nature of the
microwave emission of 3C 396. Results show a spectral energy distribution
dominated by a single component power law emission with . Data do not favour the presence of anomalous microwave emission coming
from the source. Polarised emission at 21.5 GHz is consistent with
synchrotron-dominated emission. We present microwave maps and correlate them
with infrared (IR) maps in order to characterise the interplay between thermal
dust and microwave emission. IR vs. microwave TT plots reveal poor correlation
between mid-infrared and microwave emission from the core of the source. On the
other hand, a correlation is detected in the tail emission of the outer shell
of 3C 396, which could be ascribed to Galactic contamination.Comment: published in MNRA
Evaluation of differences at high intensity threshold and its performance value during the most valuable soccer championships in Europe
The sports performance of footballers during games and training has been the subject of research for years.
Nowadays thanks to the new technologies applied to the match analysis, is possible to highlightperformance
using statistical-mathematical criteria. Recent studies support that not only the phase of the match spent at high
speeds are determinants, but even each instant in which the acceleration and deceleration values cross above the
high intensity thresholds.Our research seeks essentially to add, in the literature, a specific study, concerning
quantity and quality of work expressed on these parameters, above the high intensity thresholds, in the various
European elite championships.The search raises 26 players for each match (including substitutes), 260 athletes
per championship, for a total of 1300 players (average age 28.4 years, height 1.79 meters, weight kg 78) and
9100 parameters data.The high intensity parameters evaluated are:Distance covered at high intensity (> 16
Km/h); Distance covered in Acceleration (> 2m/s²); Distance covered in Deceleration (< -2m/s²); Distance
covered a MP> 20 Watt / Kg; Average AMP; D = Total Distance; Drel = distance/minute. Data shows that the
comparison in French league is balanced, that is high intensity activity is equal for winning and losing teams, in
German and Italian championship, winning teams work below the high intensity threshold compared with losers,
in the English and Spanish league winning teams work upper the high intensity threshold respect to losers. This
confirms that the efficiency of sport performance, in case of football the victory of competition or matches, is not
directly dependent only on the ability to carry out high-intensity activities and also supports the lack of specific
training aimed at promoting the development of such skills. A more specific investigation directed at the analysis
of only winning teams and losing teams in all championships showed a no decisive difference in high intensity
parameters. In the chart below, it is highlighted that the high intensity activity is greater in the parameters of
D_AccHI and D_DecHI in the winning teams than the losers (5-6%)
Fibroblast proliferation and migration in wound healing by phytochemicals: Evidence for a novel synergic outcome
Wound-healing is a dynamic skin reparative process that results in a sequence of events, including inflammation, proliferation, and migration of different cell types as fibroblasts. Fibroblasts play a crucial role in repairing processes, from the late inflammatory phase until the fully final epithelization of the injured tissue. Within this context, identifying tools able to implement cell proliferation and migration could improve tissue regeneration. Recently, plants species from all over the world are coming out as novel tools for therapeutic applications thanks to their phytochemicals, which have antioxidant properties and can promote wound healing. In this paper, we aimed at investigating antioxidant activity of waste extracts from different medicinal plants, endemic of the Mediterranean area, on fibroblast proliferation and wound healing. We determined the amount of total phenols and anti-oxidant activity by ABTS assay. We then evaluated the cytotoxicity of the compounds and the proliferative capabilities of fibroblasts by scratch assay. Our results showed that waste extracts retain antioxidant and regenerative properties, inducing tissue re-establishment after environmental stress exposure. Taken together, our findings suggest that waste material could be used in the future also in combinations to stimulate wound healing processes and antioxidant responses in damaged skin
Femtosecond Laser-Induced Emission of Coherent Terahertz Pulses from Ruthenium Thin Films
We demonstrate emission of electromagnetic pulses with frequencies in the terahertz (THz) range from ruthenium thin films through a second-order nonlinear optical process. Ruthenium deposited on different substrates showed different THz emission properties. We provide evidence that for Ru on glass above a certain power threshold, laser-induced oxidation occurs, resulting in an increased slope of the linear dependence of the THz electric field amplitude on pump power. The THz electric field is mainly polarized parallel to the sample surface, pointing in the same direction everywhere. In contrast to Ru on glass, the electric field amplitude of the THz pulses emitted by Ru on sapphire and on CaF2 shows a simple single linear dependence on pump power, and it is polarized orthogonal to the sample surface. In this case, thermal oxidation in an oven enhances the emission and introduces an additional polarization component along the sample surface. This component also points in the same direction everywhere on the surface, similar to the as-deposited Ru on glass. Although the precise THz generation mechanism remains an open question, our results show a strong correlation between the emission strength and the degree of oxidation. Furthermore, the results highlight the importance of the interfaces, i.e., both the choice of the substrate and the chemical composition of the top surface in THz emission experiments. Knowledge of the state of the sample surface is therefore crucial for the interpretation of THz emission experiments from (nonmagnetic) metal surfaces.</p
Drug resistance in B and non-B subtypes amongst subjects recently diagnosed as primary/recent or chronic HIV-infected over the period 2013–2016: Impact on susceptibility to first-line strategies including integrase strand-transfer inhibitors
Objectives To characterize the prevalence of transmitted drug resistance mutations (TDRMs) by plasma analysis of 750 patients at the time of HIV diagnosis from January 1, 2013 to November 16, 2016 in the Veneto region (Italy), where all drugs included in the recommended first line therapies were prescribed, included integrase strand transfer inhibitors (InNSTI). Methods TDRMs were defined according to the Stanford HIV database algorithm. Results Subtype B was the most prevalent HIV clade (67.3%). A total of 92 patients (12.3%) were expected to be resistant to one drug at least, most with a single class mutation (60/68–88.2% in subtype B infected subjectsand 23/24–95.8% in non-B subjects) and affecting mainly NNRTIs. No significant differences were observed between the prevalence rates of TDRMs involving one or more drugs, except for the presence of E138A quite only in patients with B subtype and other NNRTI in subjects with non-B infection. The diagnosis of primary/recent infection was made in 73 patients (9.7%): they had almost only TDRMs involving a single class. Resistance to InSTI was studied in 484 subjects (53 with primary-recent infection), one patient had 143C in 2016, a total of thirteen 157Q mutations were detected (only one in primary/recent infection). Conclusions Only one major InSTI-TDRM was identified but monitoring of TDRMs should continue in the light of continuing presence of NNRTI-related mutation amongst newly diagnosed subjects, sometime impacting also to modern NNRTI drugs recommended in first-line therapy
Distribution of the potassium concentration in soil with lysimeters cultivated with peanut
A aplicação de fertilizantes na agricultura pode provocar uma dinâmica de solutos no solo abaixo da zona radicular, podendo, além de provocar prejuÃzos econômicos, contaminar águas subterrâneas. O presente trabalho teve como objetivo acompanhar o processo de deslocamento do Ãon potássio (K+) em lisÃmetros preenchidos com solo de textura arenosa e cultivado com amendoim (Arachis hypogaea L.), sob diferentes condições de atenuação da densidade de fluxo radiante, como a utilização de filmes plásticos com diferentes espessuras (100 e 150 micras). O deslocamento do Ãon potássio (K+) foi monitorado por extratores de solução instalados em diferentes profundidades (15 e 25 cm), e o manejo da fertirrigação foi realizado com a utilização de tensiômetros. Concluiu-se que a baixa radiação solar incidente nos dois ambientes com coberturas plásticas afetou negativamente a produtividade do amendoim; o perÃodo em que o amendoim demanda maior quantidade de potássio ocorre dos 30 aos 55 dias após a semeadura; as plantas de amendoim não apresentaram deficiência nutricional com menor lixiviação de K+ para as camadas mais profundas do solo; nos lisÃmetros com cobertura plástica de 100 e 150 micras, ocorreu maior concentração de K+ na superfÃcie do solo.The application of fertilizers in agriculture produce some solute displacement below the root zone and this situation has provoked great impacts, besides the economic damages, causing groundwater contamination. The present work has as the objective of monitoring the displacement process of the potassium (K+) in lysimeters filled with soil, sandy texture and cultivated with peanuts (Arachis hypogaea L.) under different conditions of reducing solar radiation by using plastic films with different thickness (100 and 150 µ). The potassium displacement was monitored by soil solution extractors installed in different depths (15 and 25 cm) and the fertigation management was accomplished by tensiometers. It was concluded that low incident solar radiation in the two environments with plastic coverings negatively affected peanut's yield; the period that the peanut demands larger amount of potassium happens from 30 to 55 days after sowing; peanut plants did not present nutritional deficiency with a smaller leaching of K+ for the deepest layers of soil; in the lysimeters with plastic covering of 100 and 150 micras occurred a larger concentration of K+ in the soil surface.CNP
Energy resolution and efficiency of phonon-mediated Kinetic Inductance Detectors for light detection
The development of sensitive cryogenic light detectors is of primary interest
for bolometric experiments searching for rare events like dark matter
interactions or neutrino-less double beta decay. Thanks to their good energy
resolution and the natural multiplexed read-out, Kinetic Inductance Detectors
(KIDs) are particularly suitable for this purpose. To efficiently couple
KIDs-based light detectors to the large crystals used by the most advanced
bolometric detectors, active surfaces of several cm are needed. For this
reason, we are developing phonon-mediated detectors. In this paper we present
the results obtained with a prototype consisting of four 40 nm thick aluminum
resonators patterned on a 22 cm silicon chip, and calibrated with
optical pulses and X-rays. The detector features a noise resolution
eV and an (182) efficiency.Comment: 5 pages, 5 figure
Isolating stem cells from skin: designing a novel highly efficient non-enzymatic approach
Stem cells are undifferentiated elements capable to acquire a specific cellular phenotype under the influence of specific stimuli, thus being involved in tissue integrity and maintenance. In the skin tissue self-renewal and wound healing after injury is a complex process, especially in adulthood, due to the aging process and the continuous exposure to damaging agents. The importance of stem cells in regenerative medicine is well known and defining or improving their isolation methods is therefore a primary and crucial step. In the present paper we present a novel method to isolate stem cells from human skin, including the involvement of a novel medium for the maintenance and expansion of in vitro cultures. The biopsies were mechanically digested and put in culture. The migrating cells were positive selected with magnetic cell sorting, characterized by flow-cytometry analysis, and viability detected by MTT assay. Cells exhibited a mesenchymal phenotype, as demonstrated by the positive acquirement of an osteogenic or adipogenic phenotype when cultured in specific conditioned media. Taken together our results disclose a novel method for culturing and expanding stem cells from skin and pave the way for future clinical applications in tissue regeneration
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