Isotropic intensity waves and features of their occurrence

Waves of daily average cosmic ray intensity, dependent on interplanetary magnetic fields (IMF) polarity, have been observed in 1982 (Jacklyn and Pomerantz, 1983) and again in 1983 and 1984. These waves at first appeared to be due to the North-South anisotropy. Further investigation revealed that the waves comprise two components, a large isotropic and a smaller anisotropic component. The anisotropic part is attributed to the North-South anisotropy and is in phase with the larger isotropic component in the Southern Hemisphere. Unlike the North-South anisotropy which is a permanent feature of cosmic ray modulation, the isotropic phenomenon appears to be episodic in character. When present, it is clearly dependent on IMF polarity but does not correlate well with IMF field strength. It is conjectured that the phenomenon might indicate some difference between the intensity regimes above and below the neutral sheet

Importance of deer to resident and nonresident recreational experiences in Northern New York

152 page

A guide to managing human activity on national wildlife refuges.

78 page

Parent-child interaction in Nigerian families: conversation analysis, context and culture

This paper uses a conversation analysis (CA) approach to explore parent child interaction (PCI) within Nigerian families. We illustrate how speech and language therapists (SLTs), by using CA, can tailor recommendations according to the interactional style of each individual family that are consonant with the family’s cultural beliefs. Three parent-child dyads were videoed playing and talking together in their home environments. The analysis uncovered a preference for instructional talk similar to that used in the classroom. Closer examination revealed that this was not inappropriate when considering the context of the activities and their perceived discourse role. Furthermore, this was not necessarily at the expense of responsivity or semantic contingency. The preference for instructional talk appeared to reflect deeply held cultural beliefs about the role of adults and children within the family and it is argued that the cultural paradigm is vitally important to consider when evaluating PCI. Given a potential risk that such young children may be vulnerable in terms of language difficulties, we offer an example of how PCI can be enhanced to encourage language development without disrupting the naturally occurring talk or the underlying purpose of the interaction

PSS8 Use of consumer market research panels to generate prevalence and disease burden estimates in data-sparse diseases: a case study in severe Chronic Hand Eczema

Farrando, Jordi;Febles, Maria Dolors ;Henrich, Jordi;Tarrasó, Olga ;Fuertes, J.C.;Pérez, S

A complementary compact laser based neutron source

Several experiments of neutron generation using high intensity laser sources, with a power exceeding 10^19W/cm^2 via TNSA (Target Normal Sheath Acceleration) or other similar methods, have been performed in the past years in different laboratories. However, so far there is no one running neutron source based on such a technology. In the framework of the Conceptual Report Design of a new accelerator in the Eupraxia project we are studying the possibility to have a laser-based neutron source, not only by TNSA but also from self-injection schemes. We focus our attention on the applications in cultural heritage studies as well also on the complementary role that such a source can have in the framework of large facilities devoted to radiation production.Comment: 4 pages, two figures, 3rd European Advanced Accelerators Concept

"I'm a bit concerned" - early actions and psychological constructions in a child protection helpline

This article analyzes early actions in 50 calls reporting cases of abuse to a national child protection helpline in the UK (the National Society for the Prevention of Cruelty to Children Helpline, NSPCC). It focuses on the early turns in the caller's reason for call, in particular, a class of constructions in which the caller describes himself or herself as "concerned about x" (or similar). Analysis of the corpus of calls suggests concern constructions are canonical early elements of the reason-for-call sequence. Concern constructions (a) are oriented to a pre-move in the caller's reason for call, (b) project the unpacking of concerns in a way oriented to the NSPCCs institutional role, (c) attend to epistemological asymmetries between caller and call taker and remove the requirement for disaffiliative next actions such as asking for the basis of claims, (d) provide a way for the Child Protection Officer to take abuse claims seriously while not presupposing their truth, and (e) display an appropriate caller stance. These observations are supported by an analysis of deviant cases. The broader implications of this study for the relation between psychology, interaction, and institutions are discussed

A nonhuman primate model of inherited retinal disease.

Inherited retinal degenerations are a common cause of untreatable blindness worldwide, with retinitis pigmentosa and cone dystrophy affecting approximately 1 in 3500 and 1 in 10,000 individuals, respectively. A major limitation to the development of effective therapies is the lack of availability of animal models that fully replicate the human condition. Particularly for cone disorders, rodent, canine, and feline models with no true macula have substantive limitations. By contrast, the cone-rich macula of a nonhuman primate (NHP) closely mirrors that of the human retina. Consequently, well-defined NHP models of heritable retinal diseases, particularly cone disorders that are predictive of human conditions, are necessary to more efficiently advance new therapies for patients. We have identified 4 related NHPs at the California National Primate Research Center with visual impairment and findings from clinical ophthalmic examination, advanced retinal imaging, and electrophysiology consistent with achromatopsia. Genetic sequencing confirmed a homozygous R565Q missense mutation in the catalytic domain of PDE6C, a cone-specific phototransduction enzyme associated with achromatopsia in humans. Biochemical studies demonstrate that the mutant mRNA is translated into a stable protein that displays normal cellular localization but is unable to hydrolyze cyclic GMP (cGMP). This NHP model of a cone disorder will not only serve as a therapeutic testing ground for achromatopsia gene replacement, but also for optimization of gene editing in the macula and of cone cell replacement in general