Pattern formation by lateral inhibition with feedback: a mathematical model of Delta-Notch intercellular signalling

In many developing tissues, adjacent cells diverge in character so as to create a fine-grained pattern of cells in contrasting states of differentiation. It has been proposed that such patterns can be generated through lateral inhibition—a type cells–cell interaction whereby a cell that adopts a particular fate inhibits its immediate neighbours from doing likewise. Lateral inhibition is well documented in flies, worms and vertebrates. In all of these organisms, the transmembrane proteins Notch and Delta (or their homologues) have been identified as mediators of the interaction—Notch as receptor, Delta as its ligand on adjacent cells. However, it is not clear under precisely what conditions the Delta-Notch mechanism of lateral inhibition can generate the observed types of pattern, or indeed whether this mechanism is capable of generating such patterns by itself. Here we construct and analyse a simple and general mathematical model of such contact-mediated lateral inhibition. In accordance with experimental data, the model postulates that receipt of inhibition (i.e. activation of Notch) diminishes the ability to deliver inhibition (i.e. to produce active Delta). This gives rise to a feedback loop that can amplify differences between adjacent cells. We investigate the pattern-forming potential and temporal behavior of this model both analytically and through numerical simulation. Inhomogeneities are self-amplifying and develop without need of any other machinery, provided the feedback is sufficiently strong. For a wide range of initial and boundary conditions, the model generates fine-grained patterns similar to those observed in living systems

Surface differential rotation and prominences of the Lupus post T Tauri star RX J1508.6-4423

We present in this paper a spectroscopic monitoring of the Lupus post T Tauri star RX J1508.6-4423 carried out at two closely separated epochs (1998 May 06 and 10) with the UCL Echelle Spectrograph on the 3.9-m Anglo-Australian Telescope. Applying least-squares convolution and maximum entropy image reconstruction techniques to our sets of spectra, we demonstrate that this star features on its surface a large cool polar cap with several appendages extending to lower latitudes, as well as one spot close to the equator. The images reconstructed at both epochs are in good overall agreement, except for a photospheric shear that we interpret in terms of latitudinal differential rotation. Given the spot distribution at the epoch of our observations, differential rotation could only be investigated between latitudes 15° and 60°. We find in particular that the observed differential rotation is compatible with a solar-like law (i.e., with rotation rate decreasing towards high latitudes proportionally to sin 2l, where l denotes the latitude) in this particular latitude range. Assuming that such a law can be extrapolated to all latitudes, we find that the equator of RX J1508.6-4423 does one more rotational cycle than the pole every 50 ±10 d, implying a photospheric shear 2 to 3 times stronger than that of the Sun. We also discover that the Hα emission profile of RX J1508.6-4423 is most of the time double-peaked and strongly modulated with the rotation period of the star. We interpret this rotationally modulated emission as being caused by a dense and complex prominence system, the circumstellar distribution of which is obtained through maximum entropy Doppler tomography. These maps show in particular that prominences form a complete and inhomogeneous ring around the star, precisely at the corotation radius. We use the total Hα and Hβ emission flux to estimate that the mass of the whole prominence system is about 10 20g. From our observation that the whole cloud system surrounding the star is regenerated in less than 4 d, we conclude that the braking time-scale of RX J1508.6-4423 is shorter than 1 Gyr, and that prominence expulsion is thus likely to contribute significantly to the rotational spindown of young low-mass stars

Bistable molecular conductors with a field-switchable dipole group

A class of bistable "stator-rotor" molecules is proposed, where a stationary bridge (stator) connects the two electrodes and facilitates electron transport between them. The rotor part, which has a large dipole moment, is attached to an atom of the stator via a single sigma bond. Hydrogen bonds formed between the rotor and stator make the symmetric orientation of the dipole unstable. The rotor has two potential minima with equal energy for rotation about the sigma bond. The dipole orientation, which determines the conduction state of the molecule, can be switched by an external electric field that changes the relative energy of the two potential minima. Both orientation of the rotor correspond to asymmetric current-voltage characteristics that are the reverse of each other, so they are distinguishable electrically. Such bistable stator-rotor molecules could potentially be used as parts of molecular electronic devices.Comment: 8 pages, 7 figure

The resilience of indigenous knowledge in small-scale African agriculture: key drivers

The successful use of indigenous knowledge (IK) in development practice in rural Africa over the last couple of decades has proved to be elusive and disappointing. Using empirical field data from northern Malawi, this study suggests that the two key drivers for farmers in this area are household food security and the maintenance of soil fertility. Indigenous ways of knowing underpin the agricultural system which has been developed, rather than the adoption of more modern, ‘scientific’ ways, to deliver against these drivers. Such IKs, however, are deeply embedded in the economic, social and cultural environments in which they operate

RR Lyrae Stars In The GCVS Observed By The Qatar Exoplanet Survey

We used the light curve archive of the Qatar Exoplanet Survey (QES) to investigate the RR Lyrae variable stars listed in the General Catalogue of Variable Stars (GCVS). Of 588 variables studied, we reclassify 14 as eclipsing binaries, one as an RS Canum Venaticorum-type variable, one as an irregular variable, four as classical Cepheids, and one as a type II Cepheid, while also improving their periods. We also report new RR Lyrae sub-type classifications for 65 variables and improve on the GCVS period estimates for 135 RR Lyrae variables. There are seven double-mode RR Lyrae stars in the sample for which we measured their fundamental and first overtone periods. Finally, we detect the Blazhko effect in 38 of the RR Lyrae stars for the first time and we successfully measured the Blazhko period for 26 of them.Comment: Accepted IBV

The first WASP public data release

The WASP (wide angle search for planets) project is an exoplanet transit survey that has been automatically taking wide field images since 2004. Two instruments, one in La Palma and the other in South Africa, continually monitor the night sky, building up light curves of millions of unique objects. These light curves are used to search for the characteristics of exoplanetary transits. This first public data release (DR1) of the WASP archive makes available all the light curve data and images from 2004 up to 2008 in both the Northern and Southern hemispheres. A web interface () to the data allows easy access over the Internet. The data set contains 3 631 972 raw images and 17 970 937 light curves. In total the light curves have 119 930 299 362 data points available between them

Doppler tomography of transiting exoplanets: A prograde, low-inclined orbit for the hot Jupiter CoRoT-11b

We report the detection of the Doppler shadow of the transiting hot Jupiter CoRoT-11b. Our analysis is based on line-profile tomography of time-series, Keck/HIRES high-resolution spectra acquired during the transit of the planet. We measured a sky-projected, spin-orbit angle of 0.1 +/- 2.6 degrees, which is consistent with a very low-inclined orbit with respect to the stellar rotation axis. We refined the physical parameters of the system using a Markov chain Monte Carlo simultaneous fitting of the available photometric and spectroscopic data. An analysis of the tidal evolution of the system shows how the currently measured obliquity and its uncertainty translate into an initial absolute value of less than about 10 degrees on the zero-age main sequence, for an expected average modified tidal quality factor of the star Q'* > 4 x 10^6. This is indicative of an inward migration scenario that would not have perturbed the primordial low obliquity of CoRoT-11b. Taking into account the effective temperature and mass of the planet host star (Teff=6440 K, M*=1.23 MSun), the system can be considered a new telling exception to the recently proposed trend, according to which relatively hot and massive stars (Teff>6250 K, M*>1.2 MSun) seem to be preferentially orbited by hot Jupiters with high obliquity.Comment: 5 pages, 4 figures, accepted for publication in A&A Letter