Changes of the body functions during long-term hypokinesia

Prolonged hypokinesis (100-170 days) studied in 2000 rats kept in cages limiting their mobility provoked considerable changes in the gaseous and energetic metabolism: an elevation of the total gaseous metabolism and of the rate of O2 requirement by the muscles (in the late periods of hypokinesis) and a change in the intensity of tissue respiration of the liver and myocardium. There also proved to be a reduction in the level of phosphorylation and separation of oxidative phosphorylation in the myocardium, liver, and partially in the skeletal muscle. Prolonged hypokinesia led to changes in tissue metabolism: a disturbance of development of the animals, a marked delay and an increase in the weight of the organism and the muscular system, and disturbances of the mineral and protein metabolism. Prolonged hypokinesis also lead to exhaustion of the hypothalamus-hypophysis-adrenal cortex system

Skew-self-adjoint discrete and continuous Dirac type systems: inverse problems and Borg-Marchenko theorems

New formulas on the inverse problem for the continuous skew-self-adjoint Dirac type system are obtained. For the discrete skew-self-adjoint Dirac type system the solution of a general type inverse spectral problem is also derived in terms of the Weyl functions. The description of the Weyl functions on the interval is given. Borg-Marchenko type uniqueness theorems are derived for both discrete and continuous non-self-adjoint systems too

Quantum Phase Shift in Chern-Simons Modified Gravity

Using a unified approach of optical-mechanical analogy in a semiclassical formula, we evaluate the effect of Chern-Simons modified gravity on the quantum phase shift of de Broglie waves in neutron interferometry. The phase shift calculated here reveals, in a single equation, a combination of effects coming from Newtonian gravity, inertial forces, Schwarzschild and Chern-Simons modified gravity. However the last two effects, though new, turn out to be too tiny to be observed, and hence only of academic interest at present. The approximations, wherever used, as well as the drawbacks of the non-dynamical approach are clearly indicated.Comment: 16 pages, minor errors corrected. Accepted for publication in Phys. Rev.

Transition from damage to fragmentation in collision of solids

We investigate fracture and fragmentation of solids due to impact at low energies using a two-dimensional dynamical model of granular solids. Simulating collisions of two solid discs we show that, depending on the initial energy, the outcome of a collision process can be classified into two states: a damaged and a fragmented state with a sharp transition in between. We give numerical evidence that the transition point between the two states behaves as a critical point, and we discuss the possible mechanism of the transition.Comment: Revtex, 12 figures included. accepted by Phys. Rev.

Minimal symmetric Darlington synthesis

We consider the symmetric Darlington synthesis of a p x p rational symmetric Schur function S with the constraint that the extension is of size 2p x 2p. Under the assumption that S is strictly contractive in at least one point of the imaginary axis, we determine the minimal McMillan degree of the extension. In particular, we show that it is generically given by the number of zeros of odd multiplicity of I-SS*. A constructive characterization of all such extensions is provided in terms of a symmetric realization of S and of the outer spectral factor of I-SS*. The authors's motivation for the problem stems from Surface Acoustic Wave filters where physical constraints on the electro-acoustic scattering matrix naturally raise this mathematical issue

Cosmic ray LET spectra and doses on board Cosmos-2044 biosatellite

Results of the experiments on board Cosmos-2044 (Biosatellite 9) are presented. Various nuclear track detectors (NTD) (dielectric, AgCl-based, nuclear emulsions) were used to obtain the Linear Energy Transfer (LET) spectra inside and outside the satellite. The spectra from the different NTDs have proved to be in general agreement. The results of LET spectra calculations using two different models are also presented. The resultant LET distributions are used to calculate the absorbed and equivalent doses and the orbit-averaged quality factors (QF) of the cosmic rays (CR). Absorbed dose rates inside (approximately 20 g cm (exp -2) shielding) and outside (1 g cm(exp -2) the spacecraft, omitting electrons, were found to be 4.8 and 8.6 mrad d (exp -1), respectively, while the corresponding equivalent doses were 8.8 and 19.7 mrem d(exp -1). The effects of the flight parameters on the total fluence of, and on the dose from the CR particles are analyzed. Integral dose distributions of the detected particles are also determined. The LET values which separate absorbed and equivalent doses into 50% intervals are estimated. The CR-39 dielectric NTD is shown to detect 20-30% of the absorbed dose and 60-70% of the equivalent dose in the Cosmos-2044 orbit. The influence of solar activity phase on the magnitude of CR flux is discussed

Biodiversity of the Collembola Fauna of Wetland Kerkini (N. Greece), with description of the sexual dimorphism of Entomobrya atrocincta Schött 1896 (Collembola: Entomobryomorpha)

A report on the results of a research into some aspects of the collembolan fauna of the Greek Nature Reserve associated with Lake Kerkini, known as Wetland Kerkini, is presented. The nature reserve is large and includes a wide variety of habitats, many of which were not included in this preliminary survey. From the areas sampled we recorded 44 species, of which 39 were previously described, two (Folsomia potapovi Jordana & Baquero n. sp., Entomobrya naziridisi Jordana & Baquero n. sp.), are new to science, while three are identifi ed to generic level; a further 21 are new records for Greece, and an additional 11 species are new records to the Greek Mainland. Sampling with Berlese- Tullgren funnels and Malaise traps allowed us to capture species typical of soil and species present over vegetation. This summary is based on the records held in the online database of the Fauna Europaea Project

Linear Energy Transfer (LET) spectra of cosmic radiation in low Earth orbit

Integral linear energy transfer (LET) spectra of cosmic radiation (CR) particles were measured on five Cosmos series spacecraft in low Earth orbit (LEO). Particular emphasis is placed on results of the Cosmos 1887 biosatellite which carried a set of joint U.S.S.R.-U.S.A. radiation experiments involving passive detectors that included thermoluminescent detectors (TLD's), plastic nuclear track detectors (PNTD's), fission foils, nuclear photo-emulsions, etc. which were located both inside and outside the spacecraft. Measured LET spectra are compared with those theoretically calculated. Results show that there is some dependence of LET spectra on orbital parameters. The results are used to estimate the CR quality factor (QF) for the COSMOS 1887 mission

The pairwise disconnectivity index as a new metric for the topological analysis of regulatory networks

<p>Abstract</p> <p>Background</p> <p>Currently, there is a gap between purely theoretical studies of the topology of large bioregulatory networks and the practical traditions and interests of experimentalists. While the theoretical approaches emphasize the global characterization of regulatory systems, the practical approaches focus on the role of distinct molecules and genes in regulation. To bridge the gap between these opposite approaches, one needs to combine 'general' with 'particular' properties and translate abstract topological features of large systems into testable functional characteristics of individual components. Here, we propose a new topological parameter – the pairwise disconnectivity index of a network's element – that is capable of such bridging.</p> <p>Results</p> <p>The pairwise disconnectivity index quantifies how crucial an individual element is for sustaining the communication ability between connected pairs of vertices in a network that is displayed as a directed graph. Such an element might be a vertex (i.e., molecules, genes), an edge (i.e., reactions, interactions), as well as a group of vertices and/or edges. The index can be viewed as a measure of topological redundancy of regulatory paths which connect different parts of a given network and as a measure of sensitivity (robustness) of this network to the presence (absence) of each individual element. Accordingly, we introduce the notion of a path-degree of a vertex in terms of its corresponding incoming, outgoing and mediated paths, respectively. The pairwise disconnectivity index has been applied to the analysis of several regulatory networks from various organisms. The importance of an individual vertex or edge for the coherence of the network is determined by the particular position of the given element in the whole network.</p> <p>Conclusion</p> <p>Our approach enables to evaluate the effect of removing each element (i.e., vertex, edge, or their combinations) from a network. The greatest potential value of this approach is its ability to systematically analyze the role of every element, as well as groups of elements, in a regulatory network.</p

Outer-Sphere Contributions to the Electronic Structure of Type Zero Copper Proteins

Bioinorganic canon states that active-site thiolate coordination promotes rapid electron transfer (ET) to and from type 1 copper proteins. In recent work, we have found that copper ET sites in proteins also can be constructed without thiolate ligation (called “type zero” sites). Here we report multifrequency electron paramagnetic resonance (EPR), magnetic circular dichroism (MCD), and nuclear magnetic resonance (NMR) spectroscopic data together with density functional theory (DFT) and spectroscopy-oriented configuration interaction (SORCI) calculations for type zero Pseudomonas aeruginosa azurin variants. Wild-type (type 1) and type zero copper centers experience virtually identical ligand fields. Moreover, O-donor covalency is enhanced in type zero centers relative that in the C112D (type 2) protein. At the same time, N-donor covalency is reduced in a similar fashion to type 1 centers. QM/MM and SORCI calculations show that the electronic structures of type zero and type 2 are intimately linked to the orientation and coordination mode of the carboxylate ligand, which in turn is influenced by outer-sphere hydrogen bonding