Compositional Analysis and Antioxidant Activity of Volatile Components of Two Salvia spp

Purpose: To identify and compare the composition of volatile components of two Salvia species, and also their free radical scavenging activity.Method: The essential oil of two Salvia species was analyzed using gas chromatography-mass spectroscopy (GC-MS) techniques while their phenolic contents were analyzed by high performance liquid chromatography (HPLC). The in vitro antioxidant activity of the essential oils was evaluated by 1, 1-diphenyl-2 picryl hydrazyl (DPPH) radical scavenging technique.Results: Seven derivatives were identified for S. verticillata and four derivatives for S. suffruticosa. For both species, the main compounds were 1, 8-cineole (S. suffruticosa: 31.21 % and S. verticillata: 38.26 %) and camphor (S. suffruticosa: 27.11 % and S. verticillata: 22.98 %). The content of the phenolic compounds was: ascorbic acid (S. suffruticosa: 23.98 % and S. verticillata: 33.53 %), p- hydroxyl benzoic acid (S. suffruticosa 11.50 % and S. verticillata 3.83 %), vanilic acid (S. suffruticosa 5.86% and S. verticillata: 6.55 %), syringic acid (S. suffruticosa 6.29 %), ferulic acid (S. suffruticosa: 6.35 % and S. verticillata 6.04 %) and sinapic acid (S. suffruticosa 6.26 % and S. verticillata 4.93%). DPPH radical scavenging ability was 0.548 % for S. suffruticosa for S. suffruticosa and 0.558 % for S. verticillata.Conclusion: The results of this study demonstrated that these two species are rich in 1, 8-cineole, camphor and phenolic compounds. There is no significant difference between the radical scavenging activities of the two essential oils.Keywords: S. verticillata, S. suffruticosa, essential oil, antioxidant activity, GC-MS, HPLC activit

Inferring effective interactions from the local density of states: application to STM data from Bi2_2Sr2_2CaCu2_2O8+δ_{8+\delta}

While the influence of impurities on the local density of states (LDOS) in a metal is notoriously non-local due to interference effects, low order moments of the LDOS in general can be shown to depend only on the local structure of the Hamiltonian. Specifically, we show that an analysis of the spatial variations of these moments permits one to ``work backwards'' from scanning tunneling microscopy (STM) data to infer the local structure of the underlying effective Hamiltonian. Applying this analysis to STM data from the high temperature superconductor, Bi$_2$Sr$_2$CaCu$_2$O$_{8+\delta}$, we find that the variations of the electro-chemical potential are remarkably small (i.e., the disorder is, in a sense, weak) but that there are large variations in the local magnitude of the d-wave gap parameter.Comment: 7 pages, 7 figure

Phasor Measurement Units Optimal Placement and Performance Limits for Fault Localization

In this paper, the performance limits of faults localization are investigated using synchrophasor data. The focus is on a non-trivial operating regime where the number of Phasor Measurement Unit (PMU) sensors available is insufficient to have full observability of the grid state. Proposed analysis uses the Kullback Leibler (KL) divergence between the distributions corresponding to different fault location hypotheses associated with the observation model. This analysis shows that the most likely locations are concentrated in clusters of buses more tightly connected to the actual fault site akin to graph communities. Consequently, a PMU placement strategy is derived that achieves a near-optimal resolution for localizing faults for a given number of sensors. The problem is also analyzed from the perspective of sampling a graph signal, and how the placement of the PMUs i.e. the spatial sampling pattern and the topological characteristic of the grid affect the ability to successfully localize faults. To highlight the superior performance of presented fault localization and placement algorithms, the proposed strategy is applied to a modified IEEE 34, IEEE-123 bus test cases and to data from a real distribution grid. Additionally, the detection of cyber-physical attacks is also examined where PMU data and relevant Supervisory Control and Data Acquisition (SCADA) network traffic information are compared to determine if a network breach has affected the integrity of the system information and/or operations

Mechanistic Oral Absorption Modeling and Simulation for Formulation Development and Bioequivalence Evaluation: Report of an FDA Public Workshop

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138394/1/psp412204.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/138394/2/psp412204_am.pd

Correlation Induced Inhomogeneity in Circular Quantum Dots

Properties of the "electron gas" - in which conduction electrons interact by means of Coulomb forces but ionic potentials are neglected - change dramatically depending on the balance between kinetic energy and Coulomb repulsion. The limits are well understood. For very weak interactions (high density), the system behaves as a Fermi liquid, with delocalized electrons. In contrast, in the strongly interacting limit (low density), the electrons localize and order into a Wigner crystal phase. The physics at intermediate densities, however, remains a subject of fundamental research. Here, we study the intermediate-density electron gas confined to a circular disc, where the degree of confinement can be tuned to control the density. Using accurate quantum Monte Carlo techniques, we show that the electron-electron correlation induced by an increase of the interaction first smoothly causes rings, and then angular modulation, without any signature of a sharp transition in this density range. This suggests that inhomogeneities in a confined system, which exist even without interactions, are significantly enhanced by correlations.Comment: final version, modified introduction and clarifications, 4 page

On the absence of ferromagnetism in typical 2D ferromagnets

We consider the Ising systems in $d$ dimensions with nearest-neighbor ferromagnetic interactions and long-range repulsive (antiferromagnetic) interactions which decay with a power, $s$, of the distance. The physical context of such models is discussed; primarily this is $d=2$ and $s=3$ where, at long distances, genuine magnetic interactions between genuine magnetic dipoles are of this form. We prove that when the power of decay lies above $d$ and does not exceed $d+1$, then for all temperatures, the spontaneous magnetization is zero. In contrast, we also show that for powers exceeding $d+1$ (with $d\ge2$) magnetic order can occur.Comment: 15 pages, CMP style fil

Delineating the Role of Various Factors in Renal Disposition of Digoxin through Application of Physiologically Based Kidney Model to Renal Impairment Populations

Development of sub-models of organs within physiologically-based pharmacokinetic (PBPK) principles and beyond simple perfusion limitations may be challenging because of underdeveloped in vitro-in vivo extrapolation approaches or lack of suitable clinical data for model refinement. However, the advantage of such models in predicting clinical observations in divergent patient groups is now commonly acknowledged. Mechanistic understanding of altered renal secretion in renal impairment is one area that may benefit from such models, despite knowledge gaps in renal pathophysiology (Rowland Yeo et al., 2011; Sayama et al., 2014). In the current study a PBPK kidney model was developed for digoxin, accounting for the roles of organic anion transporting peptide 4C1 (OATP4C1) and P-glycoprotein (P-gp) in its tubular secretion, with the aim to investigate the impact of age and renal impairment (moderate to severe) on renal drug disposition. Initial PBPK simulations based on changes in glomerular filtration rate (GFR) underestimated the observed reduction in digoxin renal excretion clearance (CLR) in subjects with moderately impaired renal function relative to healthy. Reduction in either proximal tubule cell number or the OATP4C1 abundance in the mechanistic kidney model successfully predicted 59% decrease in digoxin CLR, in particular when these changes were proportional to reduction in GFR. In contrast, predicted proximal tubule concentration of digoxin was only sensitive to changes in the transporter expression/ million proximal tubule cells. Based on the mechanistic modelling, reduced proximal tubule cellularity and OATP4C1 abundance, and inhibition of OATP4C1-mediated transport, are proposed as possible causes of reduced digoxin renal secretion in renally impaired patients

Evaluation of vascular access before kidney transplantation in patients with successful kidney transplantation

Introduction: The status of embedded fistula before kidney transplant is one of the problems in patients after kidney transplant and without correct management, surely it can lead to severe complications. The vascular access of arteriovenous fistula (AVF) and its possible complications can be found using the registered data in patients who had undergone successful kidney transplant. This information may be useful to prevent possible complications in future. Objectives: This study was aimed to determine the status of vascular access before kidney transplant in patients with successful transplantation in Urmia city, Iran. Patients and Methods: This study was a historical cohort conducted on 201 patients from March 2009 to March 2012 who had undergone vascular access before kidney transplant. The related information about complications and functions of fistula were extracted from available records. Results: According to results, the patients were divided into four groups regarding fistula function including 104 patients (51.7) with functional fistula after kidney transplant, 49 patients (24.4) with spontaneously closed fistula, 37 patients (18.4) with closed fistula through surgery and 11 patients (5.5) with reduced blood flow of fistula. Conclusion: Despite the low incidence of heart failure in functional vascular access after successful renal transplantation, these patients should be followed up by cardiologists to avoid complications. Generally, closing vascular accesses after successful transplantation is not necessary. © 2019 The Author(s)