8,751 research outputs found

    Overview of colorectal cancer screening

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    Is the Tsallis entropy stable?

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    The question of whether the Tsallis entropy is Lesche-stable is revisited. It is argued that when physical averages are computed with the escort probabilities, the correct application of the concept of Lesche-stability requires use of the escort probabilities. As a consequence, as shown here, the Tsallis entropy is unstable but the thermodynamic averages are stable. We further show that Lesche stability as well as thermodynamic stability can be obtained if the homogeneous entropy is used as the basis of the formulation of non-extensive thermodynamics. In this approach, the escort distribution arises naturally as a secondary structure.Comment: 6 page

    The impact of population-based faecal occult blood test screening on colorectal cancer mortality:a matched cohort study

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    BACKGROUND: Randomised trials show reduced colorectal cancer (CRC) mortality with faecal occult blood testing (FOBT). This outcome is now examined in a routine, population-based, screening programme. METHODS: Three biennial rounds of the UK CRC screening pilot were completed in Scotland (2000–2007) before the roll out of a national programme. All residents (50–69 years) in the three pilot Health Boards were invited for screening. They received a FOBT test by post to complete at home and return for analysis. Positive tests were followed up with colonoscopy. Controls, selected from non-pilot Health Boards, were matched by age, gender, and deprivation and assigned the invitation date of matched invitee. Follow-up was from invitation date to 31 December 2009 or date of death if earlier. RESULTS: There were 379 655 people in each group (median age 55.6 years, 51.6% male). Participation was 60.6%. There were 961 (0.25%) CRC deaths in invitees, 1056 (0.28%) in controls, rate ratio (RR) 0.90 (95% confidence interval (CI) 0.83–0.99) overall and 0.73 (95% CI 0.65–0.82) for participants. Non-participants had increased CRC mortality compared with controls, RR 1.21 (95% CI 1.06–1.38). CONCLUSION: There was a 10% relative reduction in CRC mortality in a routine screening programme, rising to 27% in participants

    Accumulation horizons and period-adding in optically injected semiconductor lasers

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    We study the hierarchical structuring of islands of stable periodic oscillations inside chaotic regions in phase diagrams of single-mode semiconductor lasers with optical injection. Phase diagrams display remarkable {\it accumulation horizons}: boundaries formed by the accumulation of infinite cascades of self-similar islands of periodic solutions of ever-increasing period. Each cascade follows a specific period-adding route. The riddling of chaotic laser phases by such networks of periodic solutions may compromise applications operating with chaotic signals such as e.g. secure communications.Comment: 4 pages, 4 figures, laser phase diagrams, to appear in Phys. Rev. E, vol. 7

    From Physical to Cyber: Escalating Protection for Personalized Auto Insurance

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    Nowadays, auto insurance companies set personalized insurance rate based on data gathered directly from their customers' cars. In this paper, we show such a personalized insurance mechanism -- wildly adopted by many auto insurance companies -- is vulnerable to exploit. In particular, we demonstrate that an adversary can leverage off-the-shelf hardware to manipulate the data to the device that collects drivers' habits for insurance rate customization and obtain a fraudulent insurance discount. In response to this type of attack, we also propose a defense mechanism that escalates the protection for insurers' data collection. The main idea of this mechanism is to augment the insurer's data collection device with the ability to gather unforgeable data acquired from the physical world, and then leverage these data to identify manipulated data points. Our defense mechanism leveraged a statistical model built on unmanipulated data and is robust to manipulation methods that are not foreseen previously. We have implemented this defense mechanism as a proof-of-concept prototype and tested its effectiveness in the real world. Our evaluation shows that our defense mechanism exhibits a false positive rate of 0.032 and a false negative rate of 0.013.Comment: Appeared in Sensys 201

    The Automatic Real-Time GRB Pipeline of the 2-m Liverpool Telescope

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    The 2-m Liverpool Telescope (LT), owned by Liverpool John Moores University, is located in La Palma (Canary Islands) and operates in fully robotic mode. In 2005, the LT began conducting an automatic GRB follow-up program. On receiving an automatic GRB alert from a Gamma-Ray Observatory (Swift, INTEGRAL, HETE-II, IPN) the LT initiates a special override mode that conducts follow-up observations within 2-3 min of the GRB onset. This follow-up procedure begins with an initial sequence of short (10-s) exposures acquired through an r' band filter. These images are reduced, analyzed and interpreted automatically using pipeline software developed by our team called "LT-TRAP" (Liverpool Telescope Transient Rapid Analysis Pipeline); the automatic detection and successful identification of an unknown and potentially fading optical transient triggers a subsequent multi-color imaging sequence. In the case of a candidate brighter than r'=15, either a polarimetric (from 2006) or a spectroscopic observation (from 2007) will be triggered on the LT. If no candidate is identified, the telescope continues to obtain z', r' and i' band imaging with increasingly longer exposure times. Here we present a detailed description of the LT-TRAP and briefly discuss the illustrative case of the afterglow of GRB 050502a, whose automatic identification by the LT just 3 min after the GRB, led to the acquisition of the first early-time (< 1 hr) multi-color light curve of a GRB afterglow.Comment: PASP, accepted (8 pages, 3 figures

    Space station automation of common module power management and distribution

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    The purpose is to automate a breadboard level Power Management and Distribution (PMAD) system which possesses many functional characteristics of a specified Space Station power system. The automation system was built upon 20 kHz ac source with redundancy of the power buses. There are two power distribution control units which furnish power to six load centers which in turn enable load circuits based upon a system generated schedule. The progress in building this specified autonomous system is described. Automation of Space Station Module PMAD was accomplished by segmenting the complete task in the following four independent tasks: (1) develop a detailed approach for PMAD automation; (2) define the software and hardware elements of automation; (3) develop the automation system for the PMAD breadboard; and (4) select an appropriate host processing environment
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