Parameter Sensitivity in LSMs: An Analysis Using Stochastic Soil Moisture Models and ELDAS Soil Parameters

Integration of simulated and observed states through data assimilation as well as model evaluation requires a realistic representation of soil moisture in land surface models (LSMs). However, soil moisture in LSMs is sensitive to a range of uncertain input parameters, and intermodel differences in parameter values are often large. Here, the effect of soil parameters on soil moisture and evapotranspiration are investigated by using parameters from three different LSMs participating in the European Land Data Assimilation System (ELDAS) project. To prevent compensating effects from other than soil parameters, the effects are evaluated within a common framework of parsimonious stochastic soil moisture models. First, soil parameters are shown to affect soil moisture more strongly than the average evapotranspiration. In arid climates, the effect of soil parameters is on the variance rather than the mean, and the intermodel flux differences are smallest. Soil parameters from the ELDAS LSMs differ strongly, most notably in the available moisture content between the wilting point and the critical moisture content, which differ by a factor of 3. The ELDAS parameters can lead to differences in mean volumetric soil moisture as high as 0.10 and an average evapotranspiration of 10%–20% for the investigated parameter range. The parsimonious framework presented here can be used to investigate first-order parameter sensitivities under a range of climate conditions without using full LSM simulations. The results are consistent with many other studies using different LSMs under a more limited range of possible forcing condition

Modeled contrast in the response of the surface energy balance to heat waves for forest and grassland

Observations have shown that differences in surface energy fluxes over grasslands and forests are amplified during heat waves. The role of land-atmosphere feedbacks in this process is still uncertain. In this study, a single-column model (SCM) is used to investigate the difference between forest and grassland in their energy response to heat waves. Three simulations for the period 2005-11 were carried out: a control run using vegetation characteristics for Cabauw (the Netherlands), a run where the vegetation is changed to 100% forest, and a run with 100% short grass as vegetation. A surface evaporation tendency equation is used to analyze the impact of the land-atmosphere feedbacks on evapotranspiration and sensible heat release under normal summer and heat wave conditions with excessive shortwave radiation. Land-atmosphere feedbacks modify the contrast in surface energy fluxes between forest and grass, particularly during heat wave conditions. The surface resistance feedback has the largest positive impact, while boundary layer feedbacks generally tend to reduce the contrast. Overall, forests give higher air temperatures and drier atmospheres during heat waves. In offline land surface model simulations, the difference between forest and grassland during heat waves cannot be diagnosed adequately owing to the absence of boundary layer feedbacks

Dominant patterns of boreal summer interactions between tropics and mid-latitude: causal relationships and the role of timescales

Tropical convective activity represents a source of predictability for mid-latitude weather in the Northern Hemisphere. In winter, the El Niño–Southern Oscillation (ENSO) is the dominant source of predictability in the tropics and extra-tropics, but its role in summer is much less pronounced and the exact teleconnection pathways are not well understood. Here, we assess how tropical convection interacts with mid-latitude summer circulation at different intraseasonal time-scales and how ENSO affects these interactions. First, we apply maximum covariance analysis (MCA) between tropical convective activity and mid-latitude geopotential height fields to identify the dominant modes of interaction. The first MCA mode connects the South Asian monsoon with the mid-latitude circumglobal teleconnection pattern. The second MCA mode connects the western North Pacific summer monsoon in the tropics with a wave-5 pattern centred over the North Pacific High in the mid-latitudes. We show that the MCA patterns are fairly insensitive to the selected intraseasonal time-scale from weekly to 4-weekly data. To study the potential causal interdependencies between these modes and with other atmospheric fields, we apply causal effect networks (CEN) at different time-scales. CENs extend standard correlation analysis by removing the confounding effects of autocorrelation, indirect links and common drivers. In general, there is a two-way causal interaction between the tropics and mid-latitudes but the strength and sometimes sign of the causal link are time-scale dependent. We introduce causal maps that plot the regionally specific causal effect from each MCA mode. Those maps confirm the dominant patterns of interaction and in addition, highlight specific mid-latitude regions that are most strongly connected to tropical convection. In general, the identified causal teleconnection patterns are only mildly affected by ENSO and the tropical-mid-latitude linkages remain similar. Still, La Niña strengthens the South Asian monsoon generating a stronger response in the mid-latitudes, while during El Niño years, the Pacific pattern is reinforced. This study paves the way for process-based validation of boreal summer teleconnections in (sub)seasonal forecast models and climate models and therefore helps to improve sub-seasonal and climate projections

Seasonal evaluation of the land surface scheme HTESSEL against remote sensing derived energy fluxes of the Transdanubian region in Hungary

The skill of the land surface model HTESSEL is assessed to reproduce evaporation in response to land surface characteristics and atmospheric forcing, both being spatially variable. Evaporation estimates for the 2005 growing season are inferred from satellite observations of the Western part of Hungary and compared to model outcomes. Atmospheric forcings are obtained from a hindcast run with the Regional Climate Model RACMO2. Although HTESSEL slightly underpredicts the seasonal evaporative fraction as compared to satellite estimates, the mean, 10th and 90th percentile of this variable are of the same magnitude as the satellite observations. The initial water as stored in the soil and snow layer does not have a significant effect on the statistical properties of the evaporative fraction. However, the spatial distribution of the initial soil and snow water significantly affects the spatial distribution of the calculated evaporative fraction and the models ability to reproduce evaporation correctly in low precipitation areas in the considered region. HTESSEL performs weaker in dryer areas. In Western Hungary these areas are situated in the Danube valley, which is partly covered by irrigated cropland and which also may be affected by shallow groundwater. Incorporating (lateral) groundwater flow and irrigation, processes that are not included now, may improve HTESSELs ability to predict evaporation correctly. Evaluation of the model skills using other test areas and larger evaluation periods is needed to confirm the results. <br><br> Based on earlier sensitivity analysis, the effect of a number of modifications to HTESSEL has been assessed. A more physically based reduction function for dry soils has been introduced, the soil depth is made variable and the effect of swallow groundwater included. However, the combined modification does not lead to a significantly improved performance of HTESSEL

Epigenetic regulation of adult neural stem cells: implications for Alzheimer's disease.

Published onlineJournal ArticleResearch Support, Non-U.S. Gov'tReviewExperimental evidence has demonstrated that several aspects of adult neural stem cells (NSCs), including their quiescence, proliferation, fate specification and differentiation, are regulated by epigenetic mechanisms. These control the expression of specific sets of genes, often including those encoding for small non-coding RNAs, indicating a complex interplay between various epigenetic factors and cellular functions.Previous studies had indicated that in addition to the neuropathology in Alzheimer's disease (AD), plasticity-related changes are observed in brain areas with ongoing neurogenesis, like the hippocampus and subventricular zone. Given the role of stem cells e.g. in hippocampal functions like cognition, and given their potential for brain repair, we here review the epigenetic mechanisms relevant for NSCs and AD etiology. Understanding the molecular mechanisms involved in the epigenetic regulation of adult NSCs will advance our knowledge on the role of adult neurogenesis in degeneration and possibly regeneration in the AD brain.Internationale Stichting Alzheimer Onderzoek (ISAO)Netherlands Organization for Scientific Research (NWO)Maastricht University Medical Centre 

Giving A Face to Chemotherapy-Induced Alopecia: A Feasibility Study on Drawings by Patients

Objective: Individuals with cancer experience the impact of chemotherapy on hair loss in different ways. The aim of this pilot study was to explore patients' experiences of alopecia through patients' drawings. Methods: Fifteen female patients diagnosed with cancer and treated with chemotherapy were recruited at the oncological day-care unit of a teaching hospital in the Netherlands. Participants completed a semi-structured interview about alopecia. They drew their head and hair before and during chemotherapy and completed the Brief Illness Perception Questionnaire (B-IPQ).Results: The drawings revealed predominantly physical effects, rather than emotions. Emotions were evident in the text that patients wrote under the drawings and in the B-IPQ open question about the perceived consequences of alopecia. The overall impact of alopecia that emerged from the drawings and the B-IPQ corresponded to the information retrieved from the interviews, namely disappointment, insecurity, sadness, and confrontation.Conclusions: Drawings expose cognitive and emotional responses to alopecia that may be relatively unexplored when using traditional assessment methods such as questionnaires or interviews. In future research, the drawing instructions need to be more specifically focused on feelings in order to better capture emotional reactions to hair loss.Experimentele farmacotherapi

Histological and ultrastructural analysis of cryopreserved sheep preantral follicles

The aim of this study was to verify the histological and ultrastructural characteristics of sheep preantral follicles after exposure of ovarian tissue to cryopreservation in glycerol (GLY), ethylene glycol (EG), propanediol (PROH) or dimethyl sulfoxide (DMSO) in order to determine the optimum method to store sheep ovarian tissue for later experimental or clinical use. Each ovarian pair from five mixed-breed ewes was divided into 17 fragments. One (control) fragment was immediately fixed for routine histological and ultrastructural studies and the remaining (test) fragments were randomly distributed in cryotubes, equilibrated at 20 °C/20 min in 1.8 mL of minimal essential medium (MEM) containing 1.5 or 3 M GLY, EG, PROH or DMSO and then either fixed for morphological studies to determine their possible toxic effect or frozen/thawed and then fixed to test the effect of cryopreservation on preantral follicles. Histological analysis showed that, compared to control fragments, all cryoprotectants at both concentrations significantly reduced the percentage of normal preantral follicles in ovarian fragments prior to or after cryopreservation. PROH 3.0 M appeared to exert a more toxic effect (P < 0.05) than the other cryoprotectants in noncryopreserved tissues. After freezing/thawing, the highest (P < 0.05) percentages of lightmicroscopical normal preantral follicles were observed in ovarian fragments cryopreserved in EG (1.5 and 3 M) or DMSO (1.5 M). However, transmission electronic microscopical (TEM) examination showed that only the DMSO-cryopreserved preantral follicles had normal ultrastructure. The data suggest that sheep preantral follicles should be cryopreserved with 1.5 M DMSO for later clinical or experimental application