48 research outputs found
Giant Anisotropic Magneto-Resistance in ferromagnetic atomic contacts
Magneto-resistance is a physical effect of great fundamental and industrial
interest since it is the basis for the magnetic field sensors used in computer
read-heads and Magnetic Random Access Memories. As device dimensions are
reduced, some important physical length scales for magnetism and electrical
transport will soon be attained. Ultimately, there is a strong need to know if
the physical phenomena responsible for magneto-resistance still hold at the
atomic scale. Here, we show that the anisotropy of magneto-resistance is
greatly enhanced in atomic size constrictions. We explain this physical effect
by a change in the electronic density of states in the junction when the
magnetization is rotated, as supported by our ab-initio calculations. This
stems from the "spin-orbit coupling" mechanism linking the shape of the
orbitals with the spin direction. This sensitively affects the conductance of
atomic contacts which is determined by the overlap of the valence orbitals.Comment: latex AAMR.tex, 6 files, 5 figures, 4 pages
(http://www-drecam.cea.fr/spec/articles/S06/011
The nearest young moving groups
The latest results in the research of forming planetary systems have led
several authors to compile a sample of candidates for searching for planets in
the vicinity of the sun. Young stellar associations are indeed excellent
laboratories for this study, but some of them are not close enough to allow the
detection of planets through adaptive optics techniques. However, the existence
of very close young moving groups can solve this problem. Here we have compiled
the members of the nearest young moving groups, as well as a list of new
candidates from our catalogue of late-type stars possible members of young
stellar kinematic groups, studying their membership through spectroscopic and
photometric criteria.Comment: Latex file with 16 pages, 4 figures. Available at
http://www.ucm.es/info/Astrof/invest/actividad/skg/skg_sag.html Accepted for
publication in: The Astrophysical Journal (ApJ
The caudo-ventral pallium is a novel pallial domain expressing Gdf10 and generating Ebf3-positive neurons of the medial amygdala
In rodents, the medial nucleus of the amygdala receives direct inputs from the accessory olfactory bulbs and is mainly implicated in pheromone-mediated reproductive and defensive behaviors. The principal neurons of the medial amygdala are GABAergic neurons generated principally in the caudo-ventral medial ganglionic eminence and preoptic area. Beside GABAergic neurons, the medial amygdala also contains glutamatergic Otp-expressing neurons cells generated in the lateral hypothalamic neuroepithelium and a non-well characterized Pax6-positive population. In the present work, we describe a novel glutamatergic Ebf3-expressing neuronal subpopulation distributed within the periphery of the postero-ventral medial amygdala. These neurons are generated in a pallial domain characterized by high expression of Gdf10. This territory is topologically the most caudal tier of the ventral pallium and accordingly, we named it Caudo-Ventral Pallium (CVP). In the absence of Pax6, the CVP is disrupted and Ebf3-expressing neurons fail to be generated. Overall, this work proposes a novel model of the neuronal composition of the medial amygdala and unravels for the first time a new novel pallial subpopulation originating from the CVP and expressing the transcription factor Ebf3.This work was supported by Grants of the French National Research Agency (Agence Nationale de la Recherche; ANR) [ANR-13-BSV4-0011] and by the French Government through the ‘Investments for the Future’ LABEX SIGNALIFE [ANR-11-LABX-0028-01] to M.S., by the Spanish Government (BFU2007-60263 and BFU2010-17305) to A.F, and by the Medical Research Council (MR/K013750/1) to T.T. N.R.-R. is funded by a postdoctoral fellowship from the Ville de Nice, France (“Aide Individuelle aux Jeunes Chercheurs 2016”).Peer reviewe
Apolipoprotein A-Ib as a biomarker of focal segmental glomerulosclerosis recurrence after kidney transplantation: diagnostic performance and assessment of its prognostic value – a multi-centre cohort study
Recurrence of idiopathic focal segmental glomerulosclerosis (FSGS) is a serious complication after kidney transplantation. FSGS relapse is suspected by a sudden increase in proteinuria but there is not an accurate noninvasive diagnostic tool to confirm this entity or to detect patients at risk. We aimed to validate the diagnostic performance of ApoA-Ib to detect FSGS relapses by measuring urinary ApoA-Ib in a retrospective cohort of 61 kidney transplanted patients (37 FSGS and 24 non-FSGS). In addition, to assess the ApoA-Ib predictive ability, ApoA-Ib was measured periodically in a prospective cohort of 13 idiopathic FSGS patients who were followed during 1 year after transplantation. ApoA-Ib had a sensitivity of 93.3% and a specificity of 90.9% to diagnose FSGS relapses, with a high negative predictive value (95.2%), confirming our previous results. In the prospective cohort, ApoA-Ib predated the recurrence in four of five episodes observed. In the nonrelapsing group (n = 9), ApoA-Ib was negative in 37 of 38 samples. ApoA-Ib has the potential to be a good diagnostic biomarker of FSGS relapses, providing a confident criterion to exclude false positives even in the presence of high proteinuria. It has also the potential to detect patients at risk of relapse, even before transplantation