Governing a shared hidden resource: A review of governance mechanisms for transboundary groundwater security

© 2017 Elsevier B.V. Globally, groundwater is by far the largest store of liquid freshwater, making it a key component of a secure water supply. However, over the past few decades the amount of usable groundwater available around the world has rapidly decreased. This depletion is caused primarily by mismanagement (e.g., overpumping, contamination, and under-regulation), but also by reduced natural recharge due to climate change and urbanization. Management of groundwater resources is particularly challenging for the nearly 600 aquifers that are transboundary, meaning that they extend across international political borders. To understand how governance mechanisms can reduce water insecurity in transboundary groundwater contexts, we review key literature from what we view as the most relevant fields: groundwater management, water security, international water law and international water governance. We then formulate a set of recommendations for improved groundwater governance that can address the specific physical nature of groundwater systems, enhance water security, and apply to transboundary groundwater settings. We argue that groundwater governance in transboundary contexts requires processes that (1) enhance context-specific and flexible international mechanisms; (2) address the perpetual need for groundwater data and information; (3) prioritize the precautionary principle and pollution prevention, in particular; (4) where appropriate, integrate governance of surface and subsurface water and land; and (5) expand institutional capacity, especially of binational or multinational actors

A meta-analysis comparing the effectiveness of alternate day fasting, the 5:2 diet, and time-restricted eating for weight loss.

OBJECTIVE The objective of this meta-analysis was to compare the effectiveness of different intermittent fasting (IF) regimens on weight loss, in the general population, and compare these to traditional caloric energy restriction (CER). METHODS Three databases were searched from 2011 to June 2021 for randomized controlled trials (RCTs) that assessed weight loss and IF, including alternate day fasting (ADF), the 5:2 diet, and time-restricted eating (TRE). A random effect network analysis was used to compare the effectiveness between the three regimens. Meta-regression analysis was presented as weighted mean differences of body weight loss. RESULTS The exploratory random effects network analysis of 24 RCTs (n = 1768) ranked ADF as the most effective, followed by CER and TRE. The meta-analysis showed that IF regimens resulted in similar weight loss to CER (mean difference 0.26 kg, 95% CI: -0.31 to 0.84; p = 0.37). Compliance was generally high (>80%) in trials shorter than 3 months. CONCLUSIONS The present meta-analysis concludes that IF is comparable to CER and a promising alternative for weight loss. Among the three regimens, ADF showed the highest effectiveness for weight loss, followed by CER and TRE. Further well-powered RCTs with longer durations of intervention are required to draw solid conclusions

The decline and rise of neighbourhoods: the importance of neighbourhood governance

There is a substantial literature on the explanation of neighbourhood change. Most of this literature concentrates on identifying factors and developments behind processes of decline. This paper reviews the literature, focusing on the identification of patterns of neighbourhood change, and argues that the concept of neighbourhood governance is a missing link in attempts to explain these patterns. Including neighbourhood governance in the explanations of neighbourhood change and decline will produce better explanatory models and, finally, a better view about what is actually steering neighbourhood change

Estimates of Densities and Filling Factors from a Cooling Time Analysis of Solar Microflares Observed with RHESSI

We use more than 4,500 microflares from the Reuven Ramaty High Energy Solar Spectroscopic Imager (RHESSI) microflare data set (Christe et al., 2008, Ap. J., 677, 1385) to estimate electron densities and volumetric filling factors of microflare loops using a cooling time analysis. We show that if the filling factor is assumed to be unity, the calculated conductive cooling times are much shorter than the observed flare decay times, which in turn are much shorter than the calculated radiative cooling times. This is likely unphysical, but the contradic- tion can be resolved by assuming the radiative and conductive cooling times are comparable, which is valid when the flare loop temperature is a maximum and when external heating can be ignored. We find that resultant radiative and con- ductive cooling times are comparable to observed decay times, which has been used as an assumption in some previous studies. The inferred electron densities have a mean value of 10^11.6 cm^-3 and filling factors have a mean of 10^-3.7. The filling factors are lower and densities are higher than previous estimates for large flares, but are similar to those found for two microflares by Moore et al. (Ap. J., 526, 505, 1999).Comment: Published in Ap.

Memetic electromagnetism algorithm for surface reconstruction with rational bivariate Bernstein basis functions

Surface reconstruction is a very important issue with outstanding applications in fields such as medical imaging (computer tomography, magnetic resonance), biomedical engineering (customized prosthesis and medical implants), computer-aided design and manufacturing (reverse engineering for the automotive, aerospace and shipbuilding industries), rapid prototyping (scale models of physical parts from CAD data), computer animation and film industry (motion capture, character modeling), archaeology (digital representation and storage of archaeological sites and assets), virtual/augmented reality, and many others. In this paper we address the surface reconstruction problem by using rational Bézier surfaces. This problem is by far more complex than the case for curves we solved in a previous paper. In addition, we deal with data points subjected to measurement noise and irregular sampling, replicating the usual conditions of real-world applications. Our method is based on a memetic approach combining a powerful metaheuristic method for global optimization (the electromagnetism algorithm) with a local search method. This method is applied to a benchmark of five illustrative examples exhibiting challenging features. Our experimental results show that the method performs very well, and it can recover the underlying shape of surfaces with very good accuracy.This research is kindly supported by the Computer Science National Program of the Spanish Ministry of Economy and Competitiveness, Project #TIN2012-30768, Toho University, and the University of Cantabria. The authors are particularly grateful to the Department of Information Science of Toho University for all the facilities given to carry out this work. We also thank the Editor and the two anonymous reviewers who helped us to improve our paper with several constructive comments and suggestions

Cardiorespiratory Phase-Coupling Is Reduced in Patients with Obstructive Sleep Apnea

Cardiac and respiratory rhythms reveal transient phases of phase-locking which were proposed to be an important aspect of cardiorespiratory interaction. The aim of this study was to quantify cardio-respiratory phase-locking in obstructive sleep apnea (OSA). We investigated overnight polysomnography data of 248 subjects with suspected OSA. Cardiorespiratory phase-coupling was computed from the R-R intervals of body surface ECG and respiratory rate, calculated from abdominal and thoracic sensors, using Hilbert transform. A significant reduction in phase-coupling was observed in patients with severe OSA compared to patients with no or mild OSA. Cardiorespiratory phase-coupling was also associated with sleep stages and was significantly reduced during rapid-eye-movement (REM) sleep compared to slow-wave (SW) sleep. There was, however, no effect of age and BMI on phase coupling. Our study suggests that the assessment of cardiorespiratory phase coupling may be used as an ECG based screening tool for determining the severity of OSA

STAT3/LKB1 controls metastatic prostate cancer by regulating mTORC1/CREB pathway

Prostate cancer (PCa) is a common and fatal type of cancer in men. Metastatic PCa (mPCa) is a major factor contributing to its lethality, although the mechanisms remain poorly understood. PTEN is one of the most frequently deleted genes in mPCa. Here we show a frequent genomic co-deletion of PTEN and STAT3 in liquid biopsies of patients with mPCa. Loss of Stat3 in a Pten-null mouse prostate model leads to a reduction of LKB1/pAMPK with simultaneous activation of mTOR/CREB, resulting in metastatic disease. However, constitutive activation of Stat3 led to high LKB1/pAMPK levels and suppressed mTORC1/CREB pathway, preventing mPCa development. Metformin, one of the most widely prescribed therapeutics against type 2 diabetes, inhibits mTORC1 in liver and requires LKB1 to mediate glucose homeostasis. We find that metformin treatment of STAT3/AR-expressing PCa xenografts resulted in significantly reduced tumor growth accompanied by diminished mTORC1/CREB, AR and PSA levels. PCa xenografts with deletion of STAT3/AR nearly completely abrogated mTORC1/CREB inhibition mediated by metformin. Moreover, metformin treatment of PCa patients with high Gleason grade and type 2 diabetes resulted in undetectable mTORC1 levels and upregulated STAT3 expression. Furthermore, PCa patients with high CREB expression have worse clinical outcomes and a significantly increased risk of PCa relapse and metastatic recurrence. In summary, we have shown that STAT3 controls mPCa via LKB1/pAMPK/mTORC1/CREB signaling, which we have identified as a promising novel downstream target for the treatment of lethal mPCa