113 research outputs found
Seasonal and diurnal characteristics of water soluble inorganic compounds in the gas and aerosol phase in the Zurich area
Gas and aerosol samples were taken using a wet effluent diffusion denuder/aerosol collector (WEDD/AC) coupled to ion chromatography (IC) in the city of Zurich, Switzerland from August to September 2002 and in March 2003. Major water soluble inorganic ions; nitrate, sulfate, and nitrite were analyzed online with a time resolution of two hours for the gas and aerosol phase. The fraction of water soluble inorganic anions in PM10 varied from 15% in August to about 38% in March. Seasonal and diurnal variations of nitrate in the gas and aerosol phase were observed with more than 50% of the total nitrate in the gas phase during August and more than 80% of nitrate in the aerosol phase during March exceeding the concentration of sulfate by a factor of 2. Aerosol sulfate, on the other hand, did not show significant variability with season. However, in the gas phase, the SO<sub>2</sub> concentration was 6.5 times higher in winter than in summer. Nitrous acid (HONO) also showed a diurnal variation in both the gas and aerosol phase with the lowest concentration (0.2–0.6 µg/m<sup>3</sup>) in the afternoon. The primary pollutants, NO, CO and SO<sub>2</sub> mixing ratios were often at their highest between 04:00–10:00 local time due to the build up of fresh vehicle emission under a nocturnal inversion
Mudanças hidrológicas no pantanal associadas a processos erosivos e tectônicos na Bacia do Rio Taquari, MS.
Nas últimas décadas, grandes áreas de Cerrados de Mato Grosso do Sul foram convertidas em sistemas produtivos agrícolas e pastoris, sem a devida observância do potencial de utilização das terras. Com o tempo, algumas regiões, como a Bacia do Rio Taquari, passaram a apresentar problemas ambientais de grandes proporções em resposta a processos erosivos, cuja evolução progressiva sugere ineficiência dos sistemas de manejo visando à conservação ambiental. Os processos erosivos, estabelecidos na região de planaltos da alta Bacia do Rio Taquari, manifestam-se em escalas temporal e espacial ainda não inteiramente compreendidas e consideradas. Há falta de estudos sobre a erosão fluvial, principalmente em cabeceiras de drenagem, que acumulam grandes quantidades de matérias nas calhas dos rios da alta Bacia, cujos depósitos passam a funcionar como fonte de materiais disponíveis para transporte para o Pantanal. Mudanças hidrológicas na região baixa do lique aluvial do Taquari, com inundações permanentes em grandes áreas, são uma resposta ambiental de larga escala, cuja causa está associada a processos de intensificação da erosão na região de planaltos da alta Bacia do Rio taquari e aumento da taxa de transporte de materiais arenosos para a planície pantaneira. O transporte e a deposição de sedimentos no leito do rio Taquari, ou seja, os assoreamentos, forçam o ajuste morfológico da calha do rio incluindo a abertura de canais divergentes, os "arrombados", que permitem inundações permanentes em grandes áreas que eram de utilização pela pecuária pantaneira. Entretanto, estudos geofísicos e de sensoriamento remoto recentes indicam que essas mudanças hidrológicas, verificadas no baixo curso do rio Taquari, apresentam um padrão espacial de ocorrência e podem estar associadas ao neotectronismo, ou seja, a movimentação do embasamento no segmento do rio onde se concetram os arrombamentos de margens. O presente trabalho tem como objetivo apresentar novos dados que sugerem que, além de processos antropogênicos, processos geológicos naturais contribuem para aumentar a instabilidade dos ecossistemas da região de Cerrados e Pantanal em Mato Grosso do Sul. Um melhor conhecimento da importância relativa desses processos é fundamental no planejamento do uso e manejo de solos na Bacia do Rio Taquari.bitstream/item/104773/1/Mudanca-hidrologicas-no-pantanal.pd
Prevalence of intestinal parasitic infections among HIV patients in Benin City, Nigeria
This study was carried out to determine the presence of intestinal parasites and their correlation with CD4+ T-cell counts and demographics among human immunodeficiency virus (HIV)-positive patients in Benin City, Nigeria. Stool specimens from 2,000 HIV-positive patients and 500 controls (HIV-negative individuals) were examined for ova, cysts, or parasites, using standard procedures. In addition, patient's blood samples were analyzed for CD4 counts by flow cytometry. An overall prevalence rate of 15.3% was observed among HIV-positive patients while 6.2% was noted among non-HIV subjects. HIV status was a significant (P<0.0001) risk factor for acquiring intestinal parasitic infections. Male gender, CD4 count <200cell/µl, and diarrhea were significantly associated with an increased prevalence of intestinal parasitic infections among HIV-positive patients. The level of education, occupation, and source of water among HIV patients significantly (P<0.0001) affected the prevalence of intestinal parasitic infections. Ascaris lumbricoides was the most predominant parasite in both HIV-positive patients and controls. A CD4 count <200 cells/µl was significantly associated with only Isospora belli and Cryptosporidium infections. The presence of pathogenic intestinal parasites such as A. lumbricoides, hookworm, Giardia intestinalis, Entamoeba histolytica, Trichuris trichiura, and Taenia species among HIV-infected persons should not be neglected. Cryptosporidium species and I. belli were the opportunistic parasites observed in this study. Routine screening for intestinal parasites in HIV-positive patients is advocated
Seasonal ozone vertical profiles over North America using the AQMEII3 group of air quality models: model inter-comparison and stratospheric intrusions
This study evaluates simulated vertical ozone profiles produced in the
framework of the third phase of the Air Quality Model Evaluation
International Initiative (AQMEII3) against ozonesonde observations in North
America for the year 2010. Four research groups from the United States (US)
and Europe have provided modeled ozone vertical profiles to conduct this
analysis. Because some of the modeling systems differ in their meteorological
drivers, wind speed and temperature are also included in the analysis. In
addition to the seasonal ozone profile evaluation for 2010, we also analyze
chemically inert tracers designed to track the influence of lateral boundary
conditions on simulated ozone profiles within the modeling domain. Finally,
cases of stratospheric ozone intrusions during May–June 2010 are investigated
by analyzing ozonesonde measurements and the corresponding model simulations
at Intercontinental Chemical Transport Experiment Ozonesonde Network Study
(IONS) experiment sites in the western United States. The evaluation of the
seasonal ozone profiles reveals that, at a majority of the stations, ozone
mixing ratios are underestimated in the 1–6 km range. The seasonal change
noted in the errors follows the one seen in the variance of ozone mixing
ratios, with the majority of the models exhibiting less variability than the
observations. The analysis of chemically inert tracers highlights the
importance of lateral boundary conditions up to 250 hPa for the
lower-tropospheric ozone mixing ratios (0–2 km). Finally, for the stratospheric
intrusions, the models are generally able to reproduce the location and
timing of most intrusions but underestimate the magnitude of the maximum
mixing ratios in the 2–6 km range and overestimate ozone up to the first kilometer
possibly due to marine air influences that are not accurately described by
the models. The choice of meteorological driver appears to be a greater
predictor of model skill in this altitude range than the choice of air
quality model.</p
Positively Selected Codons in Immune-Exposed Loops of the Vaccine Candidate OMP-P1 of Haemophilus influenzae
The high levels of variation in surface epitopes can be considered as an evolutionary hallmark of immune selection. New computational tools enable analysis of this variation by identifying codons that exhibit high rates of amino acid changes relative to the synonymous substitution rate. In the outer membrane protein P1 of Haemophilus influenzae, a vaccine candidate for nontypeable strains, we identified four codons with this attribute in domains that did not correspond to known or assumed B- and T-cell epitopes of OMP-P1. These codons flank hypervariable domains and do not appear to be false positives as judged from parsimony and maximum likelihood analyses. Some closely spaced positively selected codons have been previously considered part of a transmembrane domain, which would render this region unsuited for inclusion in a vaccine. Secondary structure analysis, three-dimensional structural database searches, and homology modeling using FadL of E. coli as a structural homologue, however, revealed that all positively selected codons are located in or near extracellular looping domains. The spacing and level of diversity of these positively selected and exposed codons in OMP-P1 suggest that vaccine targets based on these and conserved flanking residues may provide broad coverage in H. influenzae
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The anti-epileptic drug Valproic Acid (VPA) inhibits steroidogenesis in bovine theca and granulosa cells in vitro
Valproic acid (VPA) is used widely to treat epilepsy and bipolar disorder. Women undergoing VPA treatment reportedly have an increased incidence of polycystic ovarian syndrome (PCOS)-like symptoms including hyperandrogenism and oligo- or amenorrhoea. To investigate potential direct effects of VPA on ovarian steroidogenesis we used primary bovine theca (TC) and granulosa (GC) cells maintained under conditions that preserve their 'follicular' phenotype. Effects of VPA (7.8-500 µg/ml) on TC were tested with/without LH. Effects of VPA on GC were tested with/without FSH or IGF analogue. VPA reduced (P99% decrease; P<0.0001) with lesser effects on LHR, STAR, CYP11A1 and HSD3B1 mRNA (<90% decrease; P<0.05). VPA only reduced TC progesterone secretion induced by the highest (luteinizing) LH dose tested; TC number was unaffected by VPA. At higher concentrations (125-500 µg/ml) VPA inhibited basal, FSH- and IGF-stimulated estradiol secretion (P<0.0001) by GC without affecting progesterone secretion or cell number. VPA reversed FSH-induced upregulation of CYP19A1 and HSD17B1 mRNA abundance (P<0.001). The potent histone deacetylase (HDAC) inhibitors trichostatin A and scriptaid also suppressed TC androstenedione secretion and granulosal cell oestrogen secretion suggesting that the action of VPA reflects its HDAC inhibitory properties. In conclusion, these findings refute the hypothesis that VPA has a direct stimulatory action on TC androgen output. On the contrary, VPA inhibits both LH-dependent androgen production and FSH/IGF-dependent estradiol production in this in vitro bovine model, likely by inhibition of HDAC
Radial Diffusion and Penetration of Gas Molecules and Aerosol Particles through Laminar Flow Reactors, Denuders, and Sampling Tubes
Flow reactors, denuders, and sampling tubes are essential tools for many applications in analytical and physical chemistry and engineering. We derive a new method for determining radial diffusion effects and the penetration or transmission of gas molecules and aerosol particles through cylindrical tubes under laminar flow conditions using explicit analytical equations. In contrast to the traditional Brown method [Brown, R. L. J. Res. Natl. Bur. Stand. (U. S.) 1978, 83, 1-8] and CKD method (Cooney, D. O.; Kim, S. S.; Davis, E. J. Chem. Eng. Sci. 1974, 29, 1731-1738), the new approximation developed in this study (known as the KPS method) does not require interpolation or numerical techniques. The KPS method agrees well with the CKD method under all experimental conditions and also with the Brown method at low Sherwood numbers. At high Sherwood numbers corresponding to high uptake on the wall, flow entry effects become relevant and are considered in the KPS and CKD methods but not in the Brown method. The practical applicability of the KPS method is demonstrated by analysis of measurement data from experimental studies of rapid OH, intermediate NO3, and slow O3 uptake on various organic substrates. The KPS method also allows determination of the penetration of aerosol particles through a tube, using a single equation to cover both the limiting cases of high and low deposition described by Gormley and Kennedy ( Proc. R. Ir. Acad., Sect. A. 1949, 52A, 163-169). We demonstrate that the treatment of gas and particle diffusion converges in the KPS method, thus facilitating prediction of diffusional loss and penetration of gases and particles, analysis of chemical kinetics data, and design of fluid reactors, denuders, and sampling lines
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