3,123 research outputs found
Dangerous Infectious Diseases: Bad news for Main Street, Good News for Wall Street?
We examine whether investor mood, driven by World Health Organization (WHO) alerts and media news on dangerous infectious diseases, is priced in pharmaceutical companies' stocks in the United States. We argue that disease-related news (DRNs) should not trigger rational trading. We find that DRNs have a positive and significant sentiment effect among investors (on Wall Street). The effect is stronger (weaker) for small (large) companies, who are less (more) likely to engage in the development of new vaccines. A potential negative investor climate (on Main Street) – induced by disease-related fear – does not alter the positive sentiment effect
Investor Sentiment and Sectoral Stock Returns: Evidence from World Cup Games
It is well known that investor sentiment affects aggregate stock returns. We investigate the economic link between sport sentiment and US sectoral stock returns. We find that sport sentiment affects only the financial sector. We argue that this result might be explained by the high liquidity that makes the financial sector more attractive to foreign investors who in turn are more prone to sport sentiment than local investors in the US. Accordingly, an arbitrageur can build a profitable trading strategy by selling short the financial sector during the FIFA World cup periods and buying it back afterwards. (C) 2016 Elsevier Inc. All rights reserved
Mutant p53 prevents GAPDH nuclear translocation in pancreatic cancer cells favoring glycolysis and 2-deoxyglucose sensitivity
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and devastating human malignancies. In about 70% of PDACs the tumor suppressor gene TP53 is mutated generally resulting in conformational changes of mutant p53 (mutp53) proteins, which acquire oncogenic functions triggering aggressiveness of cancers and alteration of energetic metabolism. Here, we demonstrate that mutant p53 prevents the nuclear translocation of the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) stabilizing its cytoplasmic localization, thus supporting glycolysis of cancer cells and inhibiting cell death mechanisms mediated by nuclear GAPDH. We further show that the prevention of nuclear localization of GAPDH is mediated by both stimulation of AKT and repression of AMPK signaling, and is associated with the formation of the SIRT1:GAPDH complex. By using siRNA-GAPDH or an inhibitor of the enzyme, we functionally demonstrate that the maintenance of GAPDH in the cytosol has a critical impact on the anti-apoptotic and anti-autophagic effects driven by mutp53. Furthermore, the blockage of its mutp53-dependent cytoplasmic stabilization is able to restore the sensitivity of PDAC cells to the treatment with gemcitabine. Finally, our data suggest that mutp53-dependent enhanced glycolysis permits cancer cells to acquire sensitivity to anti-glycolytic drugs, such as 2-deoxyglucose, suggesting a potential personalized therapeutic approach in human cancers carrying mutant TP53 gene
Double Spin Asymmetry of Electrons from Heavy Flavor Decays in p+p Collisions at sqrt(s)=200 GeV
We report on the first measurement of double-spin asymmetry, A_LL, of
electrons from the decays of hadrons containing heavy flavor in longitudinally
polarized p+p collisions at sqrt(s)=200 GeV for p_T= 0.5 to 3.0 GeV/c. The
asymmetry was measured at mid-rapidity (|eta|<0.35) with the PHENIX detector at
the Relativistic Heavy Ion Collider. The measured asymmetries are consistent
with zero within the statistical errors. We obtained a constraint for the
polarized gluon distribution in the proton of |Delta g/g(log{_10}x=
-1.6^+0.5_-0.4, {mu}=m_T^c)|^2 < 0.033 (1 sigma), based on a leading-order
perturbative-quantum-chromodynamics model, using the measured asymmetry.Comment: 385 authors, 17 pages, 15 figures, 5 tables. Submitted to Phys. Rev.
D. Plain text data tables for the points plotted in figures for this and
previous PHENIX publications are (or will be) publicly available at
http://www.phenix.bnl.gov/papers.htm
Quadrupole Anisotropy in Dihadron Azimuthal Correlations in Central Au Collisions at =200 GeV
The PHENIX collaboration at the Relativistic Heavy Ion Collider (RHIC)
reports measurements of azimuthal dihadron correlations near midrapidity in
Au collisions at =200 GeV. These measurements
complement recent analyses by experiments at the Large Hadron Collider (LHC)
involving central Pb collisions at =5.02 TeV, which
have indicated strong anisotropic long-range correlations in angular
distributions of hadron pairs. The origin of these anisotropies is currently
unknown. Various competing explanations include parton saturation and
hydrodynamic flow. We observe qualitatively similar, but larger, anisotropies
in Au collisions compared to those seen in Pb collisions at the
LHC. The larger extracted values in Au collisions at RHIC are
consistent with expectations from hydrodynamic calculations owing to the larger
expected initial-state eccentricity compared with that from Pb
collisions. When both are divided by an estimate of the initial-state
eccentricity the scaled anisotropies follow a common trend with multiplicity
that may extend to heavy ion data at RHIC and the LHC, where the anisotropies
are widely thought to arise from hydrodynamic flow.Comment: 375 authors, 7 pages, 5 figures. Published in Phys. Rev. Lett. v2 has
minor changes to text and figures in response to PRL referee suggestions.
Plain text data tables for the points plotted in figures for this and
previous PHENIX publications are (or will be) publicly available at
http://www.phenix.bnl.gov/papers.htm
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