2,173 research outputs found
Random Walks on a Fluctuating Lattice: A Renormalization Group Approach Applied in One Dimension
We study the problem of a random walk on a lattice in which bonds connecting
nearest neighbor sites open and close randomly in time, a situation often
encountered in fluctuating media. We present a simple renormalization group
technique to solve for the effective diffusive behavior at long times. For
one-dimensional lattices we obtain better quantitative agreement with
simulation data than earlier effective medium results. Our technique works in
principle in any dimension, although the amount of computation required rises
with dimensionality of the lattice.Comment: PostScript file including 2 figures, total 15 pages, 8 other figures
obtainable by mail from D.L. Stei
Connecting up strategy: are senior strategy directors a missing link?
With companies being exhorted to become more strategically agile and internally connected, this article examines the role of the Senior Strategy Director, the executive tasked specifically with internal strategy. In particular, it explores what they do, what specific capabilities they deploy to enable effective contribution to the company, and in what ways they facilitate the connectedness of strategy. An analysis of multiple interviews over time with Senior Strategy Directors of large companies shows the vital and challenging role these executives play in both shaping, connecting up, and executing strategy. This article identifies the particular capabilities necessary for Senior Strategy Directors to perform their role and shows how it all depends upon their skilful deployment. These findings have significant implications for understanding unfolding micro-processes of strategy in large organizations, for assumptions about the skills and capabilities necessary to be an effective Senior Strategy Director, and for business schools in terms of the content and style of strategy courses they provide
A categorification of Morelli's theorem
We prove a theorem relating torus-equivariant coherent sheaves on toric
varieties to polyhedrally-constructible sheaves on a vector space. At the level
of K-theory, the theorem recovers Morelli's description of the K-theory of a
smooth projective toric variety. Specifically, let be a proper toric
variety of dimension and let M_\bR = \mathrm{Lie}(T_\bR^\vee)\cong \bR^n
be the Lie algebra of the compact dual (real) torus T_\bR^\vee\cong U(1)^n.
Then there is a corresponding conical Lagrangian \Lambda \subset T^*M_\bR and
an equivalence of triangulated dg categories \Perf_T(X) \cong
\Sh_{cc}(M_\bR;\Lambda), where \Perf_T(X) is the triangulated dg category of
perfect complexes of torus-equivariant coherent sheaves on and
\Sh_{cc}(M_\bR;\Lambda) is the triangulated dg category of complex of sheaves
on M_\bR with compactly supported, constructible cohomology whose singular
support lies in . This equivalence is monoidal---it intertwines the
tensor product of coherent sheaves on with the convolution product of
constructible sheaves on M_\bR.Comment: 20 pages. This is a strengthened version of the first half of
arXiv:0811.1228v3, with new results; the second half becomes
arXiv:0811.1228v
Heat Conduction and Entropy Production in a One-Dimensional Hard-Particle Gas
We present large scale simulations for a one-dimensional chain of hard-point
particles with alternating masses. We correct several claims in the recent
literature based on much smaller simulations. Both for boundary conditions with
two heat baths at different temperatures at both ends and from heat current
autocorrelations in equilibrium we find heat conductivities kappa to diverge
with the number N of particles. These depended very strongly on the mass
ratios, and extrapolation to N -> infty resp. t -> infty is difficult due to
very large finite-size and finite-time corrections. Nevertheless, our data seem
compatible with a universal power law kappa ~ N^alpha with alpha approx 0.33.
This suggests a relation to the Kardar-Parisi-Zhang model. We finally show that
the hard-point gas with periodic boundary conditions is not chaotic in the
usual sense and discuss why the system, when kept out of equilibrium, leads
nevertheless to energy dissipation and entropy production.Comment: 4 pages (incl. 5 figures), RevTe
Chromosomes of the Asian flying squirrel Petaurista petaurista (Pallas)
Хромосомы были изучаны летаги Petaurista petaurista из Ингии; диплоидное число (2 n ) было 38 и число аутосом плечи (NF) было 72. Родство между хромосомами рода Petaurista и рода Glaucomys подсемейства Petauristinae, и Между Petaurista и Sciurus (подсемейство Sciurinae) было описывано. Находка, что диплондное число Petauristia было 38, оказывала понятие, что родовые Sciuridae обладали 2 n =38–40.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/42484/1/18_2005_Article_BF02286944.pd
Role of the 12-lipoxygenase pathway in diabetes pathogenesis and complications
12-lipoxygenase (12-LOX) is one of several enzyme isoforms responsible for the metabolism of arachidonic acid and other poly-unsaturated fatty acids to both pro- and anti-inflammatory lipid mediators. Mounting evidence has shown that 12-LOX plays a critical role in the modulation of inflammation at multiple checkpoints during diabetes development. Due to this, interventions to limit pro-inflammatory 12-LOX metabolites either by isoform-specific 12-LOX inhibition, or by providing specific fatty acid substrates via dietary intervention, has the potential to significantly and positively impact health outcomes of patients living with both type 1 and type 2 diabetes. To date, the development of truly specific and efficacious inhibitors has been hampered by homology of LOX family members; however, improvements in high throughput screening have improved the inhibitor landscape. Here, we describe the function and role of human 12-LOX, and mouse 12-LOX and 12/15-LOX, in the development of diabetes and diabetes-related complications, and describe promise in the development of strategies to limit pro-inflammatory metabolites, primarily via new small molecule 12-LOX inhibitors
Laparoscopic Splenectomy in Children
BACKGROUND: Laparoscopic splenectomy is being performed more commonly in children, although its advantages are not clear. We sought to determine whether laparoscopic splenectomy was superior to open splenectomy. METHODS: The records of all pediatric patients undergoing splenectomy without significant comorbidities over a 12-year period were examined. The patients were divided into those undergoing laparoscopic splenectomy and those undergoing open splenectomy. Demographics, operative time, estimated blood loss, spleen size, length of stay, and total charges were compared between the groups. RESULTS: Eighty-one (58%) children underwent laparoscopic splenectomy, and 59 (42%) children underwent open splenectomy. The groups were similar in age and sex; hereditary spherocytosis was more common in the LS group. Operating time was longer in the laparoscopic splenectomy group (231 +/- 10 min vs 138 +/- 9 min; P\u3c0.001), but blood loss and complication rates were similar. Twelve (15%) conversions were necessary primarily due to spleen size. Although children undergoing LS had a shorter length of stay (2.4 +/- 0.1 vs 4.1 +/- 0.3 days; P\u3c0.001), they incurred higher charges (dollars 21199 +/- 664 vs dollars 15723 +/- 1737; P\u3c0.002). CONCLUSION: Laparoscopic splenectomy is a safe procedure in children, resulting in shorter hospital stay, which may translate into earlier return to activity and a smaller burden on the child\u27s caretakers
Coarse-grained dynamics of an activity bump in a neural field model
We study a stochastic nonlocal PDE, arising in the context of modelling
spatially distributed neural activity, which is capable of sustaining
stationary and moving spatially-localized ``activity bumps''. This system is
known to undergo a pitchfork bifurcation in bump speed as a parameter (the
strength of adaptation) is changed; yet increasing the noise intensity
effectively slowed the motion of the bump. Here we revisit the system from the
point of view of describing the high-dimensional stochastic dynamics in terms
of the effective dynamics of a single scalar "coarse" variable. We show that
such a reduced description in the form of an effective Langevin equation
characterized by a double-well potential is quantitatively successful. The
effective potential can be extracted using short, appropriately-initialized
bursts of direct simulation. We demonstrate this approach in terms of (a) an
experience-based "intelligent" choice of the coarse observable and (b) an
observable obtained through data-mining direct simulation results, using a
diffusion map approach.Comment: Corrected aknowledgement
Simulations of grafted polymers in a good solvent
We present improved simulations of three-dimensional self avoiding walks with
one end attached to an impenetrable surface on the simple cubic lattice. This
surface can either be a-thermal, having thus only an entropic effect, or
attractive. In the latter case we concentrate on the adsorption transition, We
find clear evidence for the cross-over exponent to be smaller than 1/2, in
contrast to all previous simulations but in agreement with a re-summed field
theoretic -expansion. Since we use the pruned-enriched Rosenbluth
method (PERM) which allows very precise estimates of the partition sum itself,
we also obtain improved estimates for all entropic critical exponents.Comment: 5 pages with 9 figures included; minor change
A New Monte Carlo Algorithm for Protein Folding
We demonstrate that the recently proposed pruned-enriched Rosenbluth method
(P. Grassberger, Phys. Rev. E 56 (1997) 3682) leads to extremely efficient
algorithms for the folding of simple model proteins. We test them on several
models for lattice heteropolymers, and compare to published Monte Carlo
studies. In all cases our algorithms are faster than all previous ones, and in
several cases we find new minimal energy states. In addition to ground states,
our algorithms give estimates for the partition sum at finite temperatures.Comment: 4 pages, Latex incl. 3 eps-figs., submitted to Phys. Rev. Lett.,
revised version with changes in the tex
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