Excimer laser interaction with dentin of the human tooth

The use an excimer laser produced many unusual conical structures within the dentin of the inner part of the human tooth. By varying the frequency of the laser one can disperse the energy and cause more bleeding in laser surgery, but not destroy the cells associated with the incision. Therefore, the healing process will virtually be without scarring. Whereas, using the infrared laser the blood loss would be less, but the healing process would tend to be longer because cells are being destroyed due to the cauterization effect of the laser. The question is, are these structures produced as an interaction with the laser or are they an intrinsic part of the structure. The effects of the laser interaction upon dentin was studied, and in using electron microscopy the interaction of the excimer laser upon the tooth dentin and other various biological tissue is more clearly understood

The Effect of Substituting High Oil Corn as a Replacement for Normal Corn in Nursery Pig Diets

The objective of this study was to determine the production and monetary effects of using High Oil Corn (HOC) in a nursery phase feeding program and monitor growth performance differences through marketing. Two groups of weaned crossbred pigs (n = 293 trial 1; n = 265 trial 2) were segregated by sex and weight into small, medium and heavy groups and allotted to 12 nursery pens. Pigs received one of two dietary treatments which included; a transitional phase I diet for 7 days; a commercial corn soy based phase II diet (NCII) for 14 days and a phase III diet (NCIII) for 7 days; a HOC soy based phase II diet for 21 days and the NCIII diet for 7 days. Body weight, Average daily feed intake and Gain/Feed (G/F) ratios were measured weekly during the nursery period. Pigs were transferred to a grow/finish barn on d 28 post-weaning. Body weight, Backfat (BF) and Longissimus Muscle Area (LMA) at the 10th and last ribs were ultrasonically evaluated 4 times prior to market. Average daily gain of nursery pigs on the three-phase NC diet was greater than pigs fed the HOC two-phase diet at d 21 post-weaning (p = .0034) and 28 post-weaning (p = .0128). ADG for heavy pigs was greater (p = .0001) than that of medium and lightweight pigs and no treatment�weight group interactions were observed (p = .2043). Pigs fed the three-phase diet had greater G/F ratios than pigs fed the HOC two-phase diet at d 21 (p = .0137) and 28 (p = .0134). LEA for pigs fed the three-phase diet was greater than pigs fed the HOC two-phase diet when measured on d 28 at the 10th (p = .0565) and last rib (p = .0370). Even though pigs were fed alike in the grow-finish period, ADG of pigs fed the three-phase nursery diet was greater (p = .0106) than that of pigs fed the HOC two-phase nursery diet. There were no differences in the predicted 114 kg weight (p = .2658). However, economic differences were noted for the two treatments with the HOC two-phase diet lowering the cost of production of marketed animals. There were no treatment differences for average daily lean growth per day (p = .8611) or percentage lean of carcasses (p = .2865). The results did not support removal of the transitional phase I diet and the substitution of HOC for NC in a phase II diet fed to nursery pigs for maximal nursery growth, nor was carcass composition of pigs at marketing adversely affected

WRF-CMAQ two-way coupled system with aerosol feedback: software development and preliminary results

Air quality models such as the EPA Community Multiscale Air Quality (CMAQ) require meteorological data as part of the input to drive the chemistry and transport simulation. The Meteorology-Chemistry Interface Processor (MCIP) is used to convert meteorological data into CMAQ-ready input. Key shortcoming of such one-way coupling include: excessive temporal interpolation of coarsely saved meteorological input and lack of feedback of atmospheric pollutant loading on simulated dynamics. We have developed a two-way coupled system to address these issues. A single source code principle was used to construct this two-way coupling system so that CMAQ can be consistently executed as a stand-alone model or part of the coupled system without any code changes; this approach eliminates maintenance of separate code versions for the coupled and uncoupled systems. The design also provides the flexibility to permit users: (1) to adjust the call frequency of WRF and CMAQ to balance the accuracy of the simulation versus computational intensity of the system, and (2) to execute the two-way coupling system with feedbacks to study the effect of gases and aerosols on short wave radiation and subsequent simulated dynamics. Details on the development and implementation of this two-way coupled system are provided. When the coupled system is executed without radiative feedback, computational time is virtually identical when using the Community Atmospheric Model (CAM) radiation option and a slightly increased (~8.5 %) when using the Rapid Radiative Transfer Model for GCMs (RRTMG) radiation option in the coupled system compared to the offline WRF-CMAQ system. Once the feedback mechanism is turned on, the execution time increases only slightly with CAM but increases about 60 % with RRTMG due to the use of a more detailed Mie calculation in this implementation of feedback mechanism. This two-way model with radiative feedback shows noticeably reduced bias in simulated surface shortwave radiation and 2 m temperatures as well improved correlation of simulated ambient ozone and PM<sub>2.5</sub> relative to observed values for a test case with significant tropospheric aerosol loading from California wildfires

Adding four-dimensional data assimilation by analysis nudging to the Model for Prediction Across Scales – Atmosphere (version 4.0)

The Model for Prediction Across Scales – Atmosphere (MPAS-A) has been modified to allow four-dimensional data assimilation (FDDA) by the nudging of temperature, humidity, and wind toward target values predefined on the MPAS-A computational mesh. The addition of nudging allows MPAS-A to be used as a global-scale meteorological driver for retrospective air quality modeling. The technique of analysis nudging developed for the Penn State/National Center for Atmospheric Research (NCAR) Mesoscale Model, and later applied in the Weather Research and Forecasting model, is implemented in MPAS-A with adaptations for its polygonal Voronoi mesh. Reference fields generated from 1°&thinsp; × &thinsp;1° National Centers for Environmental Prediction (NCEP) FNL (Final) Operational Global Analysis data were used to constrain MPAS-A simulations on a 92–25&thinsp;km variable-resolution mesh with refinement centered over the contiguous United States. Test simulations were conducted for January and July 2013 with and without FDDA, and compared to reference fields and near-surface meteorological observations. The results demonstrate that MPAS-A with analysis nudging has high fidelity to the reference data while still maintaining conservation of mass as in the unmodified model. The results also show that application of FDDA constrains model errors relative to 2&thinsp;m temperature, 2&thinsp;m water vapor mixing ratio, and 10&thinsp;m wind speed such that they continue to be at or below the magnitudes found at the start of each test period.</p

A simple clinical scoring system to improve the sensitivity and standardization of the diagnosis of mycosis fungoides type cutaneous T-cell lymphoma: logistic regression of clinical and laboratory data

Background  The diagnosis of mycosis fungoides (MF) is notoriously difficult to establish because in the early stages, histological features may be nonspecific or merely suggestive. Objectives  To standardize the diagnosis of MF. Methods  We studied 138 patients with suspected MF referred over a 7-year period to a university department of a dermatology-based cutaneous lymphoma clinic. Six diagnostic criteria were evaluated: clinical morphology, clinical distribution, skin biopsy T-cell receptor gene rearrangement (TCR-GR), skin biopsy pan T-cell marker loss ≥ 2, skin biopsy CD4/CD8 ratio ≥ 6, and skin biopsy diffuse epidermal HLA-DR expression. These six clinical and laboratory criteria were compared by logistic regression analysis in patients with histologically diagnosed MF and those with benign disease. Results  Of the 138 patients, 74 had histology of MF, 47 of benign dermatoses and 17 were indeterminate. Close associations were found between a histological diagnosis of MF and TCR-GR (odds ratio 14·4), classical morphology (7·5), classical distribution (2·5) and diffuse epidermal HLA-DR expression (2·8). Logistic regression models were developed depending on the availability of data (either TCR-GR or HLA-DR). Probabilities for correctly diagnosing MF compared with histology as the ‘gold standard’ were derived from these logistic regression models. A scoring system assigning point values based on these probabilities was then created in order to assist the clinician in making the diagnosis. If using TCR-GR data, a positive TCR-GR = 2·5 points, the presence of classical morphology = 2·0 points, and the presence of classical distribution = 1·5 points. A total score of ≥ 3·5 points assigns a high probability (> 85%) of having MF. If using HLA-DR expression, then the presence of classical morphology = 2·5 points, a positive diffuse epidermal HLA-DR expression = 2·0 points, and the presence of classical distribution = 1·5 points. In this case, a total score of ≥ 4·0 points assigns a high probability (> 85%) of MF. Conclusions  The logistic regression models and scoring systems integrate clinical and laboratory assessments, allow rapid probability estimation, and provide a threshold for the diagnosis of MF in an objective, standardized manner.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75520/1/j.1365-2133.2003.05458.x.pd

Race and Sex Differences in QRS Interval and Associated Outcome Among Patients with Left Ventricular Systolic Dysfunction

BACKGROUND: Prolonged QRS duration is associated with increased mortality among heart failure patients, but race or sex differences in QRS duration and associated effect on outcomes are unknown. METHODS AND RESULTS: We investigated QRS duration and morphology among 2463 black and white patients with heart failure and left ventricular ejection fraction ≤35% who underwent coronary angiography and 12-lead electrocardiography at Duke University Hospital from 1995 through 2011. We used multivariable Cox regression models to assess the relationship between QRS duration and all-cause mortality and investigate race-QRS and sex-QRS duration interaction. Median QRS duration was 105 ms (interquartile range [IQR], 92-132) with variation by race and sex (P<0.001). QRS duration was longest in white men (111 ms; IQR, 98-139) followed by white women (108 ms; IQR, 92-140), black men (100 ms; IQR, 91-120), and black women (94 ms; IQR, 86-118). Left bundle branch block was more common in women than men (24% vs 14%) and in white (21%) versus black individuals (12%). In black patients, there was a 16% increase in risk of mortality for every 10 ms increase in QRS duration up to 112 ms (hazard ratio, 1.16; 95% CI, 1.07, 1.25) that was not present among white patients (interaction, P=0.06). CONCLUSIONS: Black individuals with heart failure had a shorter QRS duration and more often had non-left bundle branch block morphology than white patients. Women had left bundle branch block more commonly than men. Among black patients, modest QRS prolongation was associated with increased mortality

Incremental testing of the Community Multiscale Air Quality (CMAQ) modeling system version 4.7

This paper describes the scientific and structural updates to the latest release of the Community Multiscale Air Quality (CMAQ) modeling system version 4.7 (v4.7) and points the reader to additional resources for further details. The model updates were evaluated relative to observations and results from previous model versions in a series of simulations conducted to incrementally assess the effect of each change. The focus of this paper is on five major scientific upgrades: (a) updates to the heterogeneous N&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;5&lt;/sub&gt; parameterization, (b) improvement in the treatment of secondary organic aerosol (SOA), (c) inclusion of dynamic mass transfer for coarse-mode aerosol, (d) revisions to the cloud model, and (e) new options for the calculation of photolysis rates. Incremental test simulations over the eastern United States during January and August 2006 are evaluated to assess the model response to each scientific improvement, providing explanations of differences in results between v4.7 and previously released CMAQ model versions. Particulate sulfate predictions are improved across all monitoring networks during both seasons due to cloud module updates. Numerous updates to the SOA module improve the simulation of seasonal variability and decrease the bias in organic carbon predictions at urban sites in the winter. Bias in the total mass of fine particulate matter (PM&lt;sub&gt;2.5&lt;/sub&gt;) is dominated by overpredictions of unspeciated PM&lt;sub&gt;2.5&lt;/sub&gt; (PM&lt;sub&gt;other&lt;/sub&gt;) in the winter and by underpredictions of carbon in the summer. The CMAQv4.7 model results show slightly worse performance for ozone predictions. However, changes to the meteorological inputs are found to have a much greater impact on ozone predictions compared to changes to the CMAQ modules described here. Model updates had little effect on existing biases in wet deposition predictions

Ornamental plants, 1979: a summary of research

An analysis of production costs for containerized nursery products / David E. Hahn, Jerry L. Robertson, and Elton M. Smith -- Monoterpene investigations with creeping juniper cultivars (Juniperus horizontalis Moench.) / Thomas A. Fretz -- Woody flora in Hokkaido adaptable to the north central United States / Makoto Kawase -- An evaluation of microfoam on plant quality following overwintering of container-grown woody ornamentals / Christopher F. Rizzo, Elton M. Smith, and Thomas A. Fretz -- Evaluation of winter barrels as a heat source in woody ornamental winter storage structures / Christopher F. Rizzo, Elton M. Smith, and Thomas A. Fretz_ -- Effective utilization of applied fertilizer in relation to multiple flushes of growth on 'Helleri' holly / C. H. Gilliam and R. D. Wright -- Tissue nitrogen changes during a growth flush on 'Helleri' holly / C. H. Gilliam and R. D. Wright -- Controlling winter annual and perennial weeds in field-grown Cotoneaster divaricata / Elton M. Smith and Sharon A. Treaster -- Evaluation of oxadiazon for weed control in container-grown nursery stock / Thomas A. Fretz and Wendy J. Sheppard -- A 10-year evaluation of flowering crabapple susceptibility to apple scab in Ohio / Elton M. Smith -- Fungicides for the control of diseases of ornamental plants: results of 1977 trials / C. C. Powell and James A. Chatfield -- An evaluation of fungicides on container-grown woody ornamentals during winter storage under microfoam / Christopher F. Rizzo, Elton M. Smith, and Thomas A. Fretz -- Resistance of maple cultivars and species to verticillium wilt: a preliminary report / H. A. J. Hoitink, T. D. Sydnor, and C. L. Wilso