Optimal Public Health intervention in a behavioural vaccination model: the interplay between seasonality, behaviour and latency period

Hesitancy and refusal of vaccines preventing childhood diseases are spreading due to ‘pseudo-rational’ behaviours: parents overweigh real and imaginary side effects of vaccines. Nonetheless, the ‘Public Health System’ (PHS) may enact public campaigns to favour vaccine uptake. To determine the optimal time profiles for such campaigns, we apply the optimal control theory to an extension of the susceptible-infectious-removed (SIR)-based behavioural vaccination model by d’Onofrio et al. (2012, PLoS ONE, 7, e45653). The new model is of susceptible-exposed-infectious-removed (SEIR) type under seasonal fluctuations of the transmission rate. Our objective is to minimize the total costs of the disease: the disease burden, the vaccination costs and a less usual cost: the economic burden to enact the PHS campaigns. We apply the Pontryagin minimum principle and numerically explore the impact of seasonality, human behaviour and latency rate on the control and spread of the target disease. We focus on two noteworthy case studies: the low (resp. intermediate) relative perceived risk of vaccine side effects and relatively low (resp. very low) speed of imitation. One general result is that seasonality may produce a remarkable impact on PHS campaigns aimed at controlling, via an increase of the vaccination uptake, the spread of a target infectious disease. In particular, a higher amplitude of the seasonal variation produces a higher effort and this, in turn, beneficially impacts the induced vaccine uptake since the larger is the strength of seasonality, the longer the vaccine propensity remains large. However, such increased effort is not able to fully compensate the action of seasonality on the prevalence

Study of RPC gas mixtures for the ARGO-YBJ experiment

The ARGO-YBJ experiment consists of a RPC carpet to be operated at the Yangbajing laboratory (Tibet, P.R. China), 4300 m a.s.l., and devoted to the detection of showers initiated by photon primaries in the energy range 100 GeV - 20 TeV. The measurement technique, namely the timing on the shower front with a few tens of particles, requires RPC operation with 1 ns time resolution, low strip multiplicity, high efficiency and low single counting rate. We have tested RPCs with many gas mixtures, at sea level, in order to optimize these parameters. The results of this study are reported.Comment: 6 pages, 3 figures. To be published in Nucl. Instr. Meth. A, talk given at the "5th International Workshop on RPCs and Related Detectors", Bari (Italy) 199

Reusing Data and Metadata to Create New Metadata Through Machine-Learning & Other Programmatic Methods

Recent improvements in natural language processing (NLP) enable metadata to be created programmatically from reused original metadata or even the dataset itself. Transfer-learning applied to NLP has greatly improved performance and reduced training data requirements. In this talk, well compare machine-generated metadata to human-generated metadata and discuss characteristics of metadata and data archives that affect suitability for machine-learning reuse of metadata. Where as human-generated metadata is often populated once, populated from the perspective of data supplier, populated by many individuals with different words for the same thing, and limited in length, machine-generated metadata can be updated any number of times, generated from the perspective of any user, constrained to a standardized set of terms that can be evolved over time, and be any length required. Machine-learning generated metadata offers benefits but also additional needs in terms of version control, process transparency, human-computer interaction, and IT requirements. As a successful example, well discuss how a dataset of abstracts and associated human-tagged keywords from a standardized list of several thousand keywords were used to create a machine-learning model that predicted keyword metadata for open-source code projects on code.nasa.gov. Well also discuss a less successful example from data.nasa.gov to show how data archive architecture and characteristics of initial metadata can be strong controls on how easy it is to leverage programmatic methods to reuse metadata to create additional metadata

Physiologic and therapeutic roles of somatotropin effects in adult animals

12/94.Includes bibliographical references (pages 11-12)

The design and commissioning of the MICE upstream time-of-flight system

In the MICE experiment at RAL the upstream time-of-flight detectors are used for particle identification in the incoming muon beam, for the experiment trigger and for a precise timing (sigma_t ~ 50 ps) with respect to the accelerating RF cavities working at 201 MHz. The construction of the upstream section of the MICE time-of-flight system and the tests done to characterize its individual components are shown. Detector timing resolutions ~50-60 ps were achieved. Test beam performance and preliminary results obtained with beam at RAL are reported.Comment: accepted on Nuclear Instruments and Methods

Serum sE-selectin levels and carcinoembryonic antigen mRNA-expressing cells in peripheral blood as prognostic factors in colorectal cancer patients

This study analyzed the possible prognostic value of presurgical serum soluble (s)E-selectin levels and/or carcinoembryonic antigen (CEA) mRNA positivity in predicting the disease-free survival of colorectal cancer (CRC) patients

Prognostic value of vascular endothelial growth factor tumor tissue content of colorectal cancer

A longitudinal study was designed to quantify tumor tissue content of vascular endothelial growth factor (VEGF) in patients with colorectal cancer (CRC) and to evaluate its prognostic value in respect to the relapse-free and overall survivals