Is entrepreneurship an emerging area of research? A computational response

Objective: We aim to answer four questions. First, with the increasing number of publications, is there a concentration in specific subjects, or on the contrary, a dispersion, amplifying the span of themes related to entrepreneurship? Second, is there a hierarchy of subjects, in the sense that some of them constitute the core of entrepreneurship? Third, are they connected with other established research areas? Finally, it is possible to identify papers that are influential, acting as hubs in the clusters formation? Method: We developed an original version of the computational procedure proposed by Shibata et al (2008), which allows us to understand the diversity of the different sub-areas of the topic investigated, reducing the need for specialist supervision. Originality / Relevance: We developed and applied a method to capture the formation and evolution of research areas in entrepreneurship literature, via direct citation networks, allowing us to understand the iteration between the different research sub-areas. Results: The dispersion is a feature of entrepreneurship as field research, with a hierarchy between research areas, indicating an emergent organization in the expansion processes. We concluded that research on entrepreneurship consists of specialization, that is, by application in niches.</jats:p

Editorial: Advances in Endocrinology: Stem Cells and Growth Factors

Stem Cells investigation in Endocrinology: leading stem cell scientists and developmental endocrinologists, critically review both cutting-edge approaches to stem cell biology and the application of stem cells and their secretome to translational/precision medicine, endocrine diseases, including diabetes, tissue/organ repairs, energy metabolism, and metabolic disorders

Total Synthesis of 1”- and 2”-Hydroxycannabidiol Metabolites

Herein we report a new practical and efficient multistep syntheses of 1”- and 2”-hydroxycannabidiol metabolites. Both products and intermediates were fully characterized, and the target metabolites were produced in good overall yields

Methylcarbonate and Bicarbonate Phosphonium Salts as Catalysts for the Nitroaldol (Henry) Reaction

Phosphonium ionic liquids exchanged with bicarbonate and methylcarbonate anions (CILs) exhibit catalytic performances comparable to those of sterically hindered (non nucleophilic) organosuperbases such as DBU. At 25–50 °C, under solventless conditions, CILs efficiently catalyze the Henry addition of different aldehydes and ketones to nitroalkanes: not only they allow the selective formation of nitroaldols but they unlock a novel high-yielding access to dinitromethyl derivatives of ketones

Coexistence of carcinoma and tuberculosis in one breast

which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background: The coexistence of breast cancer and tuberculosis is very rare. This can create a dilemma in the diagnosis and treatment as there are no pathognomonic symptoms or signs to distinguish both diseases. Case presentation: A female patient was seen in the breast clinic for a right breast lump. Clinical examination and investigation confirmed cancer and tuberculosis of the right breast. She underwent right mastectomy and axillary clearance and received chemo and radiotherapy. Unfortunately, she died of wide spread metastases. Conclusion: The simultaneous occurrence of these two major illnesses in the breast can lead to many problems regarding diagnosis and treatment. Though rare, surgeons, pathologists and radiologists should be aware of such condition. Background The coexistence of carcinoma and tuberculosis (TB) of the breast and the axillary lymph nodes is rare. The clinical situation

Eco-friendly synthesis of beta-nitro ketones from conjugated enones: an important improvement of the Miyakoshi procedure

A variety of alpha,beta-unsaturated ketones can be easily converted, at room temperature, into beta-nitro ketones by nitration with solid supported nitrite (SSN) and in the presence of acetic acid and cyclopentyl methyl ether

Analogies de méthodes et différences d'appareillage dans l'enregistrement d'informations corrélées

L'enregistrement des énergies de particules corrélées : expériences (α, γ), (3He, dγ), (d, pγ), (p, p' γ), expériences de polarisation [4, 6,12], a été effectué indépendamment avec des appareillages de conceptions différentes. L'un est un système d'acquisition et de contrôle utilisant une logique câblée, l'autre un ordinateur en temps réel. L'examen critique de ces appareillages et de leur utilisation conduit à des conclusions voisines

Is the Non-Coding RNA miR-195 a Biodynamic Marker in the Pathogenesis of Head and Neck Squamous Cell Carcinoma? A Prognostic Meta-Analysis

Head and neck squamous cell carcinoma (HNSCC) represents a heterogeneous group of neoplasms whose histological derivation comes from the mucous membranes lining the epithelium: the oral cavity, the larynx, the hypopharynx, the nasopharynx, and the oropharynx. The etiopathogenetic mechanisms involving tumor genesis including the alteration of cell proliferation, apoptosis, invasion, migration, and death may involve alterations in the expression of microRNA (miR). To date there have been no systematic reviews with meta-analysis conducted specifically on the role of miR-195 in HNSCC; therefore, our hypothesis was to evaluate if the aberrant expression of miR-195 in HNSCC tissues may represent a prognostic biomarker of survival through the hazard ratio (HR) and relative risk (RR) analysis. The systematic review was designed according to the PRISMA indications; in total, three electronic databases were consulted (PubMed, Scopus, Cochrane Central Trial) including Google Scholar and the gray literature, and a combination of keywords was used such as miR-195 AND HNSCC, microRNA AND HNSCC and miR-195. The meta-analysis and trial sequential analysis were performed using RevMan 5.41 software and TSA software (Cochrane Collaboration, Copenhagen, Denmark). This search identified 1592 articles and, at the end of the selection process, three articles were included. The results of the meta-analysis reported an aggregated risk ratio for overall survival (OS) between the expression of miR-195 at the highest and lowest of 0.36 and 6, respectively, 95% CI: [0.25, 0.51]. Heterogeneity was evaluated through Chi2 = 0.05 df = 2 (p = 0.98) and the Higgins index I2 = 0%. The test for the overall effect was Z = 5.77 (p < 0.00001). The forest plot was in favor of higher OS in patients with high miR-195 expression

Peripheral Purinergic Modulation in Pediatric Orofacial Inflammatory Pain Affects Brainstem Nitroxidergic System: A Translational Research

Physiology of orofacial pain pathways embraces primary afferent neurons, pathologic changes in the trigeminal ganglion, brainstem nociceptive neurons, and higher brain function regulating orofacial nociception. The goal of this study was to investigate the nitroxidergic system alteration at brainstem level (spinal trigeminal nucleus), and the role of peripheral P2 purinergic receptors in an experimental mouse model of pediatric inflammatory orofacial pain, to increase knowledge and supply information concerning orofacial pain in children and adolescents, like pediatric dentists and pathologists, as well as oro-maxillo-facial surgeons, may be asked to participate in the treatment of these patients. The experimental animals were treated subcutaneously in the perioral region with pyridoxalphosphate-6-azophenyl-2′,4′-disulphonic acid (PPADS), a P2 receptor antagonist, 30 minutes before formalin injection. The pain-related behavior and the nitroxidergic system alterations in the spinal trigeminal nucleus using immunohistochemistry and western blotting analysis have been evaluated. The local administration of PPADS decreased the face-rubbing activity and the expression of both neuronal and inducible nitric oxide (NO) synthase isoforms in the spinal trigeminal nucleus. These results underline a relationship between orofacial inflammatory pain and nitroxidergic system in the spinal trigeminal nucleus and suggest a role of peripheral P2 receptors in trigeminal pain transmission influencing NO production at central level. In this way, orofacial pain physiology should be elucidated and applied to clinical practice in the future