Non-invasive ventilation (NIV) as an aid to rehabilitation in acute respiratory disease

<p>Abstract</p> <p>Background</p> <p>Non-invasive ventilation (NIV) can increase exercise tolerance, reduce exercise induced desaturation and improve the outcome of pulmonary rehabilitation in patients with chronic respiratory disease. It is not known whether it can be applied to increase exercise capacity in patients admitted with non-hypercapnic acute exacerbations of COPD (AECOPD). We investigated the acceptability and feasibility of using NIV for this purpose.</p> <p>Methods</p> <p>On a single occasion, patients admitted with an acute exacerbation of chronic respiratory disease who were unable to cycle for five minutes at 20 watts attempted to cycle using NIV and their endurance time (T_lim) was recorded. To determine feasibility of this approach in clinical practice patients admitted with AECOPD were screened for participation in a trial of regular NIV assisted rehabilitation during their hospital admission.</p> <p>Results</p> <p>In 12 patients tested on a single occasion NIV increased T_limfrom 184(65) seconds to 331(229) seconds (p = 0.04) and patients desaturated less (median difference = 3.5%, p = 0.029). In the second study, 60 patients were admitted to hospital during a three month period of whom only 18(30)% were eligible to participate and of these patients, only four (7%) consented to participate.</p> <p>Conclusion</p> <p>NIV improves exercise tolerance in patients with acute exacerbations of chronic respiratory disease but the applicability of this approach in routine clinical practice may be limited.</p> <p>Trial registration</p> <p><url>http://www.controlled-trials.com/ISRCTN35692743</url></p

Predictors of single word spelling in English-speaking children: a cross sectional study

Background: The study aimed to explore to what extent variables associated with lexical and sublexical spelling processes predicted single word spelling ability, and whether patterns of lexical and sublexical processes were different across ages. Methods: Beginning (mean age 7-years, N=144) and advanced (mean age 9-years, N=114) English-speaking spellers completed tasks associated with sublexical processing (phonological ability and phonological short-term memory), lexical processing (visual short-term memory, visual attention span), and factors known to predict spelling (e.g., rapid automatised naming). Results: Phonological ability, rapid automatised naming, visual short-term memory and visual attention span were significant predictors of spelling accuracy for beginning spellers, while for more advanced spellers, only visual attention span was a significant predictor. Conclusions: The findings suggested that for beginning spellers, both lexical and sublexical processes are important for single word spelling, but with increasing literacy experience, lexically related variables are more important