145 research outputs found
Обработка оптических измерений траектории летательных объектов
Рассмотрены методы уравнивания угловых измерений по способу наименьших квадратов: метод уравнивания измерений отдельно в каждом временном сечении, предполагающий нулевое математическое ожидание случайных ошибок измерений, и метод уравнивания избыточных оптических измерений с подавлением их постоянных систематических ошибок в предположении засоренности измерений как случайными, так и неизвестными по величине и знаку систематическими погрешностями.Розглянуто методи зрівнювання кутових вимірювань за способом найменших квадратів: метод зрівнювання вимірювань окремо в кожному часовому розрізі, що передбачає нульове математичне очікування випадкових похибок вимірювань, і метод зрівнювання надлишкових оптичних вимірювань із заглушенням їх постійних систематичних похибок у припущенні засміченості вимірювань як випадковими, так і невідомими за величиною та знаком систематичними похибками.The methods of equalizing angular measurements according to the method of least squares are examined: the method of equalizing measurements separately in each temporary section, that assumes the zero mathematical expectation of the random errors of measurements, and the method of equalizing excessive optical measurements with suppression of their constant systematic errors under the assumption of the obstruction of measurements by systematic errors both random and unknowns by value and sign
Clostridium difficile Infections amongst Patients with Haematological Malignancies: A Data Linkage Study
OBJECTIVES: Identify risk factors for Clostridium difficile infection (CDI) and assess CDI outcomes among Australian patients with a haematological malignancy. METHODS: A retrospective cohort study involving all patients admitted to hospitals in Western Australia with a haematological malignancy from July 2011 to June 2012. Hospital admission data were linked with all hospital investigated CDI case data. Potential risk factors were assessed by logistic regression. The risk of death within 60 and 90 days of CDI was assessed by Cox Proportional Hazards regression. RESULTS: There were 2085 patients of whom 65 had at least one CDI. Twenty percent of CDI cases were either community-acquired, indeterminate source or had only single-day admissions in the 28 days prior to CDI. Using logistic regression, having acute lymphocytic leukaemia, neutropenia and having had bacterial pneumonia or another bacterial infection were associated with CDI. CDI was associated with an increased risk of death within 60 and 90 days post CDI, but only two deaths had CDI recorded as an antecedent factor. Ribotyping information was available for 33 of the 65 CDIs. There were 19 different ribotypes identified. CONCLUSIONS: Neutropenia was strongly associated with CDI. While having CDI is a risk factor for death, in many cases it may not be a direct contributor to death but may reflect patients having higher morbidity. A wide variety of C. difficile ribotypes were found and community-acquired infection may be under-estimated in these patients
2 days versus 5 days of postoperative antibiotics for complex appendicitis:a pragmatic, open-label, multicentre, non-inferiority randomised trial
Background: The appropriate duration of postoperative antibiotics for complex appendicitis is unclear. The increasing global threat of antimicrobial resistance warrants restrictive antibiotic use, which could also reduce side-effects, length of hospital stay, and costs. Methods: In this pragmatic, open-label, non-inferiority trial in 15 hospitals in the Netherlands, patients with complex appendicitis (aged ≥8 years) were randomly assigned (1:1) to receive 2 days or 5 days of intravenous antibiotics after appendicectomy. Randomisation was stratified by centre, and treating physicians and patients were not masked to treatment allocation. The primary endpoint was a composite endpoint of infectious complications and mortality within 90 days. The main outcome was the absolute risk difference (95% CI) in the primary endpoint, adjusted for age and severity of appendicitis, with a non-inferiority margin of 7·5%. Outcome assessment was based on electronic patient records and a telephone consultation 90 days after appendicectomy. Efficacy was analysed in the intention-to-treat and per-protocol populations. Safety outcomes were analysed in the intention-to-treat population. This trial was registered with the Netherlands Trial Register, NL5946. Findings: Between April 12, 2017, and June 3, 2021, 13 267 patients were screened and 1066 were randomly assigned, 533 to each group. 31 were excluded from intention-to-treat analysis of the 2-day group and 30 from the 5-day group owing to errors in recruitment or consent. Appendicectomy was done laparoscopically in 955 (95%) of 1005 patients. The telephone follow-up was completed in 664 (66%) of 1005 patients. The primary endpoint occurred in 51 (10%) of 502 patients analysed in the 2-day group and 41 (8%) of 503 patients analysed in the 5-day group (adjusted absolute risk difference 2·0%, 95% CI −1·6 to 5·6). Rates of complications and re-interventions were similar between trial groups. Fewer patients had adverse effects of antibiotics in the 2-day group (45 [9%] of 502 patients) than in the 5-day group (112 [22%] of 503 patients; odds ratio [OR] 0·344, 95% CI 0·237 to 0·498). Re-admission to hospital was more frequent in the 2-day group (58 [12%] of 502 patients) than in the 5-day group (29 [6%] of 503 patients; OR 2·135, 1·342 to 3·396). There were no treatment-related deaths. Interpretation: 2 days of postoperative intravenous antibiotics for complex appendicitis is non-inferior to 5 days in terms of infectious complications and mortality within 90 days, based on a non-inferiority margin of 7·5%. These findings apply to laparoscopic appendicectomy conducted in a well resourced health-care setting. Adopting this strategy will reduce adverse effects of antibiotics and length of hospital stay. Funding: The Netherlands Organization for Health Research and Development.</p
Autoimmune gastrointestinal complications in patients with Systemic Lupus Erythematosus: case series and literature review
The association of systemic lupus erythematosus (SLE) with gastrointestinal autoimmune diseases is rare, but has been described in the literature, mostly as case reports. However, some of these diseases may be very severe, thus a correct and early diagnosis with appropriate management are fundamental. We have analysed our data from the SLE patient cohort at University College Hospital London, established in 1978, identifying those patients with an associated autoimmune gastrointestinal disease. We have also undertaken a review of the literature describing the major autoimmune gastrointestinal pathologies which may be coincident with SLE, focusing on the incidence, clinical and laboratory (particularly antibody) findings, common aetiopathogenesis and complications
Viral, bacterial, and fungal infections of the oral mucosa:Types, incidence, predisposing factors, diagnostic algorithms, and management
Understanding similarities and differences in land use visions for Scotland
The successful transition towards a global society that can live within planetary
boundaries is one of the greatest challenges for the twenty-first century.
Sustainable land use and land management will be essential to ensure the
continued delivery of the ecosystem goods and services needed to support a
rapidly growing global population. To support the transition towards sustainable
development, decision-makers need to better understand how land use change
affects people and the environment. However, these insights are of limited use
without societal agreement on future land uses. Understanding synergies and
differences between land use visions forms a first step in assessing and comparing
alternative pathways towards a sustainable future.
This thesis uses a range of methods to understand visions of future land use
amongst professional land use stakeholders, society at large, and young people in
Scotland. Twenty semi-structured interviews were held with policy experts from
the Scottish land use sectors. A nationwide statistically representative web-based
survey provided insight into the visions of the Scottish population. And finally, a
novel visual interview methodology was used to interview 26 pupils from two high
schools in Perthshire. Inductive content analysis and descriptive statistics were
used to analyse the results and understand and compare the land use visions of
these different groups.
As expected, different groups had different visions of future land use. There was,
however, general agreement on certain themes, in particular the desire for a more
sustainable lifestyle and the importance of a healthy environment.
The sectoral stakeholders would like to see more partnerships, dialogue and
collaboration; a society that is more engaged and aware about land use; resilient
local economies; and short-, medium-, and long-term policies that help to achieve
these goals. One of the key challenges for these groups will be how to translate
abstract concepts such as ‘healthy ecosystem’ and ‘dialogue and partnerships’ into
practice. This clearly requires a shared understanding of what a ‘healthy
ecosystem’ means to different stakeholders, as well as appreciation of what true
dialogue means and how this can be used to co-create solutions – potentially a
radical change from the traditional top-down approaches.
The research also identified divisions in Scottish society between those who want
to continue a ‘status quo’ lifestyle, and those – in particular younger people (who
spent time in the natural environment, through either school or home life) and
those from a higher socio-economic background – who want a more sustainable
lifestyle and to be more connected with the natural environment. These results are
important, as policy makers need to be able to identify the factors that have
successfully engaged certain groups and to promote these factors. Programmes
that provide access to the natural environment (such as the Duke of Edinburgh’s
Award) need to ensure equal opportunities by targeting disadvantaged groups.
Simultaneously, it needs to be explored how to encourage those who would like to
continue a ‘status quo’ lifestyle into a more sustainable one. Past research has
shown how preferences can be influenced and how changes can be initiated by
incentives and restrictions in order to promote desired behaviours. The power of
the media should be leveraged: programmes such as BBC’s ‘Blue Planet’ highlight
how our lifestyle choices impact on the natural environment and can provide the
motivation for change.
The current issues surrounding Brexit and Climate Change require a national
conversation; using methods such as those presented in the thesis to elicit land use
visions can help identify the commonalties and differences between stakeholders’
views. This can provide a starting point for dialogue and critical reflection on
current instruments and objectives, and how they might be adapted to better
reflect Scottish preferences and conditions
Practicalities and challenges in re-orienting the health system in Zambia for treating chronic conditions
- …