Synthetic calcium carbonate improves the effectiveness of treatments with nanolime to contrast decay in highly porous limestone

Three synthetized polymorphs of calcium carbonate have been tested in combination with the suspension of nanolime particles as potential consolidating agents for contrasting stone decay and overcome some of the limitations of nanolime agents when applied to substrates with large porosity. The modifications induced in the pore network of the Maastricht limestone were analyzed with microscopy and in a non-invasive fashion with small angle neutron scattering and synchrotron radiation micro-computed tomography. A reduction in porosity and pore accessibility at the micrometric scale was detected with the latter technique, and ascribed to the improved pore-filling capacity of the consolidation agent containing CaCO3 particles. These were found to be effectively bound to the carbonated nanolime, strengthening the pore-matrix microstructure. Penetration depth and positive effect on porosity were found to depend on the particle size and shape. Absence of significant changes in the fractal nature of the pore surface at the nanoscale, was interpreted as indication of the negligible contribution of nanolime-based materials in the consolidation of stones with large porosity. However, the results indicate that in such cases, their effectiveness may be enhanced when used in combination with CaCO3 particles, owing to the synergic effect of chemical/structural compatibility and particle size distribution

Design of a novel LOX-1 receptor antagonist mimicking the natural substrate

The lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), the major receptor for oxidized low-density lipoprotein (ox-LDL) in endothelial cells, is overexpressed in atherosclerotic lesions. LOX-1 specific inhibitors, urgently necessary to reduce the rate of atherosclerotic and inflammation processes, are not yet available. We have designed and synthesized a new modified oxidized phospholipid, named PLAzPC, which plays to small scale the ligand-receptor recognition scheme. Molecular docking simulations confirm that PLAzPC disables the hydrophobic component of the ox-LDL recognition domain and allows the interaction of the l-lysine backbone charged groups with the solvent and with the charged/polar residues located around the edges of the LOX-1 hydrophobic tunnel. Binding assays, in a cell model system expressing human LOX-1 receptors, confirm that PLAzPC markedly inhibits ox-LDL binding to LOX-1 with higher efficacy compared to previously identified inhibitors

Cardiac resynchronization therapy after coronary sinus lead extraction: feasibility and mid-term outcome of transvenous reimplantation in a tertiary referral centre

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A Smart Bluetooth-based Ad Hoc Management System for Appliances in Home Environments

The number of home devices integrating new technologies is continuously increasing. These advances allow us to improve our daily routines. In addition, the improvement in network infrastructure and the development of smart phones and mobile devices allow us access from any place to any of our systems over the Internet. Bearing in mind this idea, we have developed a low-cost ad hoc protocol based on Bluetooth technology that allows us to control all our home appliances and monitor the power consumption of our homes. Our proposal is based on an Android application installed on a mobile device which acts as server. The application allows users to program the various appliances. It is also able to check the status of the appliance, as well as controlling the power consumption of the house and its cost. The system is equipped with a smart algorithm able to manage all appliances and decide which ones should work as a function of various criteria such as time of day or power consumption. Finally, the system is able to detect faults in water and electricity supply for acting accordingly. All data received and sent by the server are stored in a database which the system can check and compare to make their own decisions.Sendra, S.; Laborda, A.; Díaz Santos, JR.; Lloret, J. (2015). A Smart Bluetooth-based Ad Hoc Management System for Appliances in Home Environments. Springer Verlag (Germany): LNCS. 8487:128-141. doi:10.1007/978-3-319-07425-2_10S1281418487Garcia, M., Sendra, S., Lloret, J., Canovas, A.: Saving energy and improving communications using cooperative group-based Wireless Sensor Networks. Telecommunication Systems 52(4), 2489–2502 (2013)Liu, Y., Zhou, G.: Technologies and Applications of Internet of Things. In: Proceedings of 2012 Fifth International Conference on Intelligent Computation Technology and Automation (ICICTA), Zhangjiajie, China, January 12-14, pp. 197–200 (2012)Aiello, M.: The Role of Web Services at Home. In: Proceedings of the Advanced International Conference on Telecommunications and International Conference on Internet and Web Applications and Services (AICT-ICIW 2006), Guadeloupe, France, February 23-25 (2006)Mowafi, M.Y., Awad, F.H., Al-Batati, M.A.: Opportunistic Network Coding for Real-Time Transmission over Wireless Networks. Network Protocols and Algorithms 5(1), 1–19 (2013)Gangadhar, G., Nayak, S., Puttamadappa, C.: Intelligent Refrigerator with monitoring capability through internet. International Journal of Computer Applications. Special Issue on “Wireless Information Networks & Business Information System 2(7), 65–68 (2011)Soucek, S., Russ, G., Tamarit, C.: The Smart Kitchen Project—An Application of Fieldbus Technology to Domotics. 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Solar cycle variation of νmax in helioseismic data and its implications for asteroseismology

The frequency, νmax, at which the envelope of pulsation power peaks for solar-like oscillators is an important quantity in asteroseismology. We measure νmax for the Sun using 25 yr of Sun-as-a-star Doppler velocity observations with the Birmingham Solar-Oscillations Network (BiSON), by fitting a simple model to binned power spectra of the data. We also apply the fit to Sun-as-a-star Doppler velocity data from Global Oscillation Network Group and Global Oscillations at Low Frequency, and photometry data from VIRGO/SPM on the ESA/NASA SOHO spacecraft. We discover a weak but nevertheless significant positive correlation of the solar νmax with solar activity. The uncovered shift between low and high activity, of $\simeq 25\, \rm \mu Hz$, translates to an uncertainty of 0.8 per cent in radius and 2.4 per cent in mass, based on direct use of asteroseismic scaling relations calibrated to the Sun. The mean νmax in the different data sets is also clearly offset in frequency. Our results flag the need for caution when using νmax in asteroseismology

Metabolic profiles of whole, parotid and submandibular/sublingual saliva

The detection of salivary molecules associated with pathological and physiological alterations has encouraged the search of novel and non-invasive diagnostic biomarkers for oral health evaluation. While genomic, transcriptomic, and proteomic profiles of human saliva have been reported, its metabolic composition is a topic of research: metabolites in submandibular/sublingual saliva have never been analyzed systematically. In this study, samples of whole, parotid, and submandibular/ sublingual saliva from 20 healthy donors, without dental or periodontal diseases, were examined by nuclear magnetic resonance. We identified metabolites which are differently distributed within the three saliva subtypes (54 in whole, 49 in parotid, and 36 in submandibular/sublingual saliva). Principal component analysis revealed a distinct cluster for whole saliva and a partial overlap for parotid and submandibular/sublingual metabolites. We found exclusive metabolites for each subtype: 2-hydroxy-3-methylvalerate, 3-methyl-glutarate, 3-phenylpropionate, 4-hydroxyphenylacetate, 4-hydroxyphenyllactate, galactose, and isocaproate in whole saliva; caprylate and glycolate in submandibular/sublingual saliva; arginine in parotid saliva. Salivary metabolites were classified into standard and non-proteinogenic amino acids and amines; simple carbohydrates; organic acids; bacterial-derived metabolites. The identification of a salivary gland-specific metabolic composition in healthy people provides the basis to invigorate the search for salivary biomarkers associated with oral and systemic diseases

Measurement of event shapes in deep inelastic scattering at HERA

Inclusive event-shape variables have been measured in the current region of the Breit frame for neutral current deep inelastic ep scattering using an integrated luminosity of 45.0 pb^-1 collected with the ZEUS detector at HERA. The variables studied included thrust, jet broadening and invariant jet mass. The kinematic range covered was 10 < Q^2 < 20,480 GeV^2 and 6.10^-4 < x < 0.6, where Q^2 is the virtuality of the exchanged boson and x is the Bjorken variable. The Q dependence of the shape variables has been used in conjunction with NLO perturbative calculations and the Dokshitzer-Webber non-perturbative corrections (`power corrections') to investigate the validity of this approach.Comment: 7+25 pages, 6 figure

Safety and Efficacy of Ombitasvir, Paritaprevir With Ritonavir ± Dasabuvir With or Without Ribavirin in Patients With Human Immunodeficiency Virus-1 and Hepatitis C Virus Genotype 1 or Genotype 4 Coinfection: TURQUOISE-I Part 2.

BACKGROUND: Ombitasvir, paritaprevir with ritonavir, and dasabuvir (OBV/PTV/r ± DSV) ±ribavirin (RBV) are approved to treat hepatitis C virus (HCV) genotype 1 and 4 infection. Here, we investigate the safety and efficacy of OBV/PTV/r + DSV ±RBV for HCV genotype 1, and OBV/PTV/r + RBV for HCV genotype 4, in human immunodeficiency virus (HIV)-1 coinfected patients with or without compensated cirrhosis. METHODS: TURQUOISE-I, Part 2 is a phase 3 multicenter study. Patients with or without cirrhosis were HCV treatment-naive or -experienced, on an HIV-1 antiretroviral regimen containing atazanavir, raltegravir, dolutegravir, or darunavir (for genotype 4 only), and had plasma HIV-1 ribonucleic acid <40 copies/mL at screening. Patients received OBV/PTV/r ± DSV ±RBV for 12 or 24 weeks. RESULTS: In total, 228 patients were treated according to guidelines. Sustained virologic response at posttreatment week 12 (SVR12) was achieved by 194 of 200 (97%) and 27 of 28 (96%) patients with HCV genotype 1 and genotype 4 infection, respectively. There were 2 virologic failures: 1 breakthrough and 1 relapse in a cirrhotic and a noncirrhotic patient with genotype 1b and 1a infection, respectively. One reinfection occurred at posttreatment week 12 in a genotype 1a-infected patient. Excluding nonvirologic failures, the SVR12 rates were 98% (genotype 1) and 100% (genotype 4). Adverse events were mostly mild in severity and did not lead to discontinuation. Laboratory abnormalities were rare. CONCLUSIONS: The OBV/PTV/r ±DSV was well tolerated and yielded high SVR12 rates in patients with HCV genotype 1 or genotype 4/HIV-1 coinfection. The OBV/PTV/r ± DSV ±RBV is a potent HCV treatment option for patients with HIV-1 coinfection, regardless of treatment experience

Angular and Current-Target Correlations in Deep Inelastic Scattering at HERA

Correlations between charged particles in deep inelastic ep scattering have been studied in the Breit frame with the ZEUS detector at HERA using an integrated luminosity of 6.4 pb-1. Short-range correlations are analysed in terms of the angular separation between current-region particles within a cone centred around the virtual photon axis. Long-range correlations between the current and target regions have also been measured. The data support predictions for the scaling behaviour of the angular correlations at high Q2 and for anti-correlations between the current and target regions over a large range in Q2 and in the Bjorken scaling variable x. Analytic QCD calculations and Monte Carlo models correctly describe the trends of the data at high Q2, but show quantitative discrepancies. The data show differences between the correlations in deep inelastic scattering and e+e- annihilation.Comment: 26 pages including 10 figures (submitted to Eur. J. Phys. C