The nature of close companions of the BL Lac Objects 1ES 0502+675 and 1ES 1440+122

We report on deep radio images and optical spectroscopy of two BL Lac objects that have very close compact companions. The two targets, 1ES 0502+675 and 1ES 1440+122, were selected from the HST imaging survey of 110 BL Lacs as candidates for possible gravitational lensing. The new observations clearly demonstrate that the companion objects are not secondary images of the active nuclei but, in spite of the relatively low chance projection probability, foreground Galactic stars. Gravitational lensing appears to be unimportant to the BL Lac phenomenon. We discuss the radio properties of the BL Lac objects in the context of standard beaming models, and show they are as expected for beamed FRI radio galaxies.Comment: 13 pages, 5 figures, ApJ in pres

Optical Morphologies of Millijansky Radio Galaxies Observed by HST and in the VLA FIRST Survey

We report on a statistical study of the 51 radio galaxies at the millijansky flux level from the Faint Images of the Radio Sky at Twenty centimeters, including their optical morphologies and structure obtained with the Hubble Space Telescope. Our optical imaging is significantly deeper (~2 mag) than previous studies with the superior angular resolution of space-based imaging. We that find 8/51 (16%) of the radio sources have no optically identifiable counterpart to AB~24 mag. For the remaining 43 sources, only 25 are sufficiently resolved in the HST images to reliably assign a visual classification: 15 (60%) are elliptical galaxies, 2 (8%) are late-type spiral galaxies, 1 (4%) is an S0, 3 (12%) are point-like objects (quasars), and 4 (16%) are merger systems. We find a similar distribution of optical types with measurements of the Sersic index. The optical magnitude distribution of these galaxies peaks at I~20.7+-0.5 AB mag, which is ~3 mag brighter than the depth of our typical HST field and is thus not due to the WFPC2 detection limit. This supports the luminosity-dependent density evolutionary model, where the majority of faint radio galaxies typically have L*-optical luminosities and a median redshift of z~0.8 with a relatively abrupt redshift cut-off at z>~2. We discuss our results in the context of the evolution of elliptical galaxies and active galactic nuclei.Comment: 20 pages, 8 figures, 51 galaxy images, and 5 tables. Uses emulateapj.cls and natbib.sty. Accepted to ApJS. High resolution images are available upon reques

Obscuration and Origin of Nuclear X-ray emission in FR I Radio Galaxies

We present X-ray observations of the nuclear region of 25 Fanaroff-Riley I radio galaxies from the 3CRR and B2 catalogs, using data from the Chandra and XMM archives. We find the presence of a X-ray Central Compact Core (CCCX) in 13/25 sources, in 3/25 sources the detection of a CCCX is uncertain, while in the remaining 9/25 sources no CCCX is found. All the sources are embedded in a diffuse soft X-ray component, generally on kpc-scales, which is in agreement with the halo of the host galaxy and/or with the intracluster medium. The X-ray spectra of the cores are described by a power law with photon indices Gamma=1.1 - 2.6. In 8 sources excess absorption over the Galactic value is detected, with rest-frame column densities N_H^z ~ 10^20 - 10^21 cm^-2; thus, we confirm the previous claim based on optical data that most FRI radio galaxies lack a standard optically-thick torus. We find significant correlations between the X-ray core luminosity and the radio and optical luminosities, suggesting that at least a fraction of the X-ray emission originates in a jet; however, the origin of the X-rays remains ambiguous. If the X-ray emission is entirely attributed to an isotropic, accretion-related component, we find very small Eddington ratios, L_bol/L_Edd ~ 10^-3 - 10^-8, and we calculate the radiative efficiency to be eta ~ 10^-2 - 10^-6, based on the Bondi accretion rates from the spatial analysis. This suggests that radiatively inefficient accretion flows are present in the cores of low-power radio galaxies.Comment: 20 pages, 7 figures, accepted for publication in The Astrophysical Journa

A design of experiments (DoE) approach to identify the influencing parameters that determine poly-D,L-lactic acid (PDLLA) electrospun scaffold morphologies

Electrospun fibrous materials have increasing applications in regenerative medicine due to the similarity of fibre constructs to the morphology of certain extracellular matrices. Although experimentally the electrospinning method is relatively simple, at the theoretical level the interactions between process parameters and their influence on the fibre morphology is not yet fully understood. Here, we hypothesised that a design of experiments (DoE) model could determine combinations of process parameters that result in significant effects on poly-D,L-lactic acid (PDLLA) fibre morphology. The process parameters used in this study were applied voltage, needle-to-collector distance, flow rate and polymer concentration. Data obtained for mean fibre diameter, standard deviation of the fibre diameter (stdev, measure of fibre morphology) and presence of 'beading' on the fibres (beads per µm2) were evaluated as a measure of PDLLA fibre morphology. Uniform fibres occurred at standard deviations of ≤ 500 nm, 'beads-on-string' morphologies were apparent between ± 500-1300 nm and large beads were observed at ± 1300-1800 nm respectively. Mean fibre diameter was significantly influenced by the applied voltage and interaction between flow rate and polymer concentration. Fibre morphology was mainly influenced by the polymer concentration, while bead distribution was significantly influenced by the polymer concentration as well as the flow rate. The resultant DoE model regression equations were tested and considered suitable for the prediction of parameters combinations needed for desired PDLLA fibre diameter and additionally provided information regarding the expected fibre morphology

Differential impact of two risk communications on antipsychotic prescribing to people with dementia in Scotland: segmented regression time series analysis 2001-2011

The two risk communications were associated with reductions in antipsychotic use, in ways which were compatible with marked differences in their content and dissemination. Further research is needed to ensure that the content and dissemination of regulatory risk communications is optimal, and to track their impact on intended and unintended outcomes. Although rates are falling, antipsychotic prescribing in dementia in Scotland remains unacceptably hig

X-ray-emitting Atmospheres of B2 Radio Galaxies

We report ROSAT PSPC spatial and spectral analysis of the eight B2 radio galaxies NGC 315, NGC 326, 4C 35.03, B2 0326+39, NGC 2484, B2 1040+31, B2 1855+37, and 3C 449, expected to be representative of the class of low-power radio galaxies. Multiple X-ray components are present in each, and the gas components have a wide range of linear sizes and follow an extrapolation of the cluster X-ray luminosity/temperature correlation, implying that there is no relationship between the presence of a radio galaxy and the gas fraction of the environment. No large-scale cooling flows are found. There is no correlation of radio-galaxy size with the scale or density of the X-ray atmosphere. This suggests that it is processes on scales less than those of the overall gaseous environments which are the major influence on radio-source dynamics. The intergalactic medium is usually sufficient to confine the outer parts of the radio structures, in some cases even to within 5 kpc of the core. In the case of NGC 315, an extrapolation suggests that the pressure of the atmosphere may match the minimum pressure in the radio source over a factor of about 40 in linear size (a factor of about 1600 in pressure).Comment: 34 pages, including 10 figures, using aasms4.sty To appear in the Ap

An Unusual Discontinuity in the X-ray Surface Brightness Profile of NGC 507: Evidence of an Abundance Gradient?

We present results from a 45 ks Chandra/ACIS-I observation of the nearby ($z=0.01646$) NGC 507 group. The X-ray surface brightness profile of the outer region of the group is well described by an isothermal $\beta$-profile consistent with earlier ROSAT observations. We find a sharp edge or discontinuity in the radial surface brightness profile 55 kpc E and SE of NGC 507 covering a $\sim125^\circ$ arc. At the sharpest part of the discontinuity, the surface brightness declines by a factor of $\sim$2 over a distance of 6.9 kpc ($\sim 15''$). The inner and outer gas temperatures across the discontinuity differ by only about 0.2 keV (interior and exterior gas temperatures are 1.2 and 1.3 keV, respectively). Spectral analysis indicates that there is a large gradient in the elemental abundance across the discontinuity, and comparison with the low resolution NVSS radio maps suggests that the discontinuity is aligned with a low surface brightness radio lobe. We conclude that the appearance of this discontinuity is the result of the transport of high abundance material from the center of the galaxy by the expanding radio lobe, similar to structures seen in {\em Chandra} observations of Perseus A and Hydra A.Comment: 15 pages, 6 figures, submitted to Astrophysical Journal Letter

The electrospinning of a thermo-responsive polymer with peptide conjugates for phenotype support and extracellular matrix production of therapeutically relevant mammalian cells

Current cell expansion methods for tissue engineering and regenerative medicine applications rely on the use of enzymatic digestion passaging and 2D platforms. However, this enzymatic treatment significantly reduces cell quality, due to the destruction of important cell-surface proteins. In addition, culture in 2D results in undesired de-differentiation of the cells caused by the lack of 3D similarity to the natural extracellular matrix (ECM) environment. Research has led to the development of thermo-responsive surfaces for the continuous culture of cells. These thermo-responsive materials properties can be used to passage cells from the surface when the cell culture temperature is reduced. Here we report the development of a PLA/thermo-responsive (PDEGMA) blend 3D electrospun fibre-based scaffold to create an enzymatic-free 3D cell culture platform for the expansion of mammalian cells with the desired phenotype for clinical use. Human corneal stromal cells (hCSCs) were used as an exemplar as they have been observed to de-differentiate to an undesirable myo-fibroblastic phenotype when cultured by conventional 2D cell culture methods. Scaffolds were functionalised with a cell adherence peptide sequence GGG-YIGSR by thiol-ene chemistry to improve cell adherence and phenotype support. This was obtained by functionalising the thermo-responsive polymer with a thiol (PDEGMA/PDEGSH) by co-polymerisation. These incorporated thiols react with the norbornene acid functionalised peptide (Nor-GGG-YIGSR) under UV exposure. Presence of the thiol in the scaffold and subsequent peptide attachment on the scaffolds were confirmed by fluorescence labelling, ToF-SIMS and XPS analysis. The biocompatibility of the peptide containing scaffolds was assessed by the adhesion, proliferation and immuno-staining of hCSCs. Significant increase in hCSC adherence and proliferation was observed on the peptide containing scaffolds. Immuno-staining showed maintained expression of the desired phenotypic markers ALDH, CD34 and CD105, while showing no or low expression of the undesired phenotype marker α-SMA. This desired expression was observed to be maintained after thermo-responsive passaging and higher when cells were cultured on PLA scaffolds with 10 wt% PDEGMA/4 mol% PDEGS-Nor-GGG-YIGSR. This paper describes the fabrication and application of a first generation, biocompatible peptide conjugated thermo-responsive fibrous scaffold. The ease of fabrication, successful adherence and expansion of a therapeutically relevant cell type makes these scaffolds a promising new class of materials for the application of cell culture expansion platforms in the biomaterials and tissue engineering field