Web-based Text Mining

Text mining deals with retrieval of specific information provided by customer search engines. With the massive amount of information that is available on the World Wide Web, text mining provides results in the order of highest relevance to the key words in the query. Text expresses a vast, rich range of information, but encodes this information in a form that is difficult to decipher automatically. For example, it is much more difficult to graphically display textual content than quantitative data. In this paper we describe a method for choosing a subset of the Web, an approach to create a search a flexible service to adopt a new way to generate highly effective results for expert searches. Retrieval of information poses the problem of redundancy in retrieval of same data repeatedly. This paper presents an optimized solution for fast recovery of data and also finds methods for regenerating the queries from the queries posed

A Review On Omaveloxolone

Omaveloxolone is a semisynthetic triterpenoid used to treat friedreich’s ataxia. It is the second generation oleananetriterpenoid Nrf2 inducer with antioxidant and anti-inflammatory properties. It is currently used to test in medical trials for freidreich’s ataxia, a genetic, multi –organ disease involving mitochondrial dysfunction. It is a nuclear factor erythroid 2 related factor 2 (Nrf2) activator. It is reviewed under Food and Drug Administration and it has the potential to first approved treatment for friedreich’s ataxia. Omaveloxolone is not the cure for friedreich’s ataxia, it is the first agent targeting to reach NDA submission. It is the rational and potent therapy that is probably disease modifying in the treatment of friedreich’s ataxia. Omaveloxolone (RTA-408) is an Nrf2 activator, which decreases the susceptibility of cells through oxidative stress and it leads to cell death and tissue degradation. It is good tolerated not having any significant long term adverse effects. Treatment with RTA-408 remarkably improved in the neurological function, it is measured by modified Freidreich’s Ataxia Rating Scale

Carbon stocks in major cashew growing soils of coastal Karnataka, India

This study was taken up to assess the soil organic carbon (SOC) stock under cashew plantations in different management conditions viz., natural (cashew mixed with forest trees and cashew in scrub land conditions) and intensive management (research stations) in regions/locations of coastal Karnataka. Profile study was undertaken and six major soil series were identified. Horizon-wise soil samples were collected from different layers of soil profiles and the major soil properties viz., bulk density, pH, EC, particle size distribution and SOC were determined using standard laboratory procedures. The SOC stock was high in surface soils (2.0 to 8.23 kg C m-2) compared to subsoils (0.08 to 3.28 kg C m-2) and it decreased with depth. The maximum SOC was found in mixed forest land use system followed by cashew plantation in scrub land and in research farm. The SOC stock in different depths (0-30, 30-100 and 0-100 cm) of the soils varied from 2.37 to 9.70 kg C m-2 and 1.48 to 5.69 kg C m-2, respectively. Result indicated that cashew plantation under natural management has more SOC stock and high carbon sequestration potential-than intensively managed cashew plantations

Evaluation of Pulsed Electromagnetic Field in the management of osteoarthritis using Electromyography – An Interventional study

Knee pain is one of the most frequent musculoskeletal problems among the middle-aged and elderly people and ‘Osteoarthritis’ is the widespread clinical pathology of the knee. Objective: The present study was conducted to evaluate whether low frequency Pulsed Electro Magnetic Field (PEMF) therapy is effective in patients with osteoarthritis knee using surface Electromyography (sEMG) of vastus medialis. Methods: The participants were subjected to Pulsed Electromagnetic Field Therapy using the PULSATRON  instrument designed by Madras Institute of Magnetobiology, Anna nagar. They were given PEMF therapy of 10 Hz for 60 minutes/ day for 21 days with a break after every 6 days. The participants of the study were subjected to Electromyography of vastus medialis using the MEDICAID PHYSIOPAC machine. The findings are compared before and after the duration of PEMF therapy. Results: The study shows that Low frequency PEMF (10 Hz) can be used as a treatment modality for Osteoarthritis. PEMF therapy, when given for a sufficient time (21 days) can improve the stiffness and the power of muscles as seen by the increase in amplitude of electromyography. The mean amplitude of sEMG in vastus medialis was found to be significantly increased (p <0.001) in the study group following the Pulsed Electro Magnetic Field (PEMF) therapy

Diagnosis of alcohol misuse and alcoholic liver disease among patients in the medical emergency admission service of a large urban hospital in Sub-Saharan Africa; a cross sectional study

Introduction: Uganda is among the top ten consumers of alcohol worldwide though there is little data on alcohol related liver disease. We describe alcohol use, alcohol misuse, and alcoholic liver disease among adults at the emergency admission service of a large urban hospital in Uganda. Methods: All adults who consented were prospectively evaluated for alcohol use by inquiry and alcohol misuse by the "Cutting down, Annoyance, Guilt and Eye-opener- CAGE" questionnaire. Alcohol related hepatocellular liver injury was assessed using aspartate aminotransferase, and alanine aminotransferase levels. A combination of CAGE score ≥2 and De Ritis ratio ≥2 defined alcoholic liver disease (ALD). Human Immunodeficiency Virus (HIV), and viral hepatitis B and C serologies were evaluated in all the patients. Descriptive and inferential statistics were generated to answer our research questions. Results: Three hundred and eighty individuals consented and participated in the study. Among these, 46.8% acknowledged use of alcohol while 21% and 10% met the study definition of alcoholic misuse and alcoholic liver disease respectively. Both alcohol misuse and alcoholic liver disease was significantly associated (p-value ≤ 0.05) with male gender, region of origin, number of life time sexual partners and serum albumin below 3.5 mg/dl after univariate and multivariate analysis. Conclusion: Alcohol misuse and alcoholic liver disease is frequent in this medical emergency unit. Our study suggests a link between alcohol misuse or alcoholic liver disease and male gender, region of origin, number of sexual partners, and serum albumin below 3.5mg/dl.Key words: Alcohol use, alcohol misuse, alcoholic liver disease, aspartate aminotransferase, alanine aminotransferase, CAGE questionnaire, De Ritisrati

Enhancing Employability of Management Graduates of State Universities in Sri Lanka: An Examination of Job Market Requirements

Higher education helps in enhancing the human resources required for development. Universities and higher education institutes play a vital role in disseminating and creating knowledge through teaching and research, contributing to the development of any country. The quality and relevance of the output (graduates) of higher education institutes need to be enhanced to increase graduates’ employability. Graduate unemployment has become a significant problem in Sri Lanka. If graduates are unemployed, this will directly and negatively influence economic development. The main objectives of this study are to identify job market requirements of the industry and factors affecting the success of the graduates’ interviews. This study used qualitative research methods as a mono method.  Data were collected using advertisements from two selected leading English and Sinhala weekend newspapers published from October 2019 to January 2020, and in-depth interviews were conducted with selected Human Resource managers. Newspaper analysis and job market requirement analysis were done using an inductive thematic analysis approach. Five core skills were identified as the job market requirements, namely, problem-solving skills, communication skills, numeracy skills, computer skills, and interpersonal skills. Leadership qualities, communication and presentation ability, teamwork, interpersonal relations, practical knowledge, positive attitudes, hardworking characteristics, well-preparedness at the interview, and a clear understanding of the graduate's career path mainly affect the graduate interview's success. The study proposes policy measures to improve the employability of management graduates of state universities in Sri Lanka.  Keywords: Employability, Management Graduates, State Universities, job market requirements, Sri Lank

Cytotoxic clinical isolates of Pseudomonas aeruginosa identified during the Steroids for Corneal Ulcers Trial show elevated resistance to fluoroquinolones.

BackgroundTo determine the relationship between type three secretion genotype and fluoroquinolone resistance for P. aeruginosa strains isolated from microbial keratitis during the Steroids for Corneal Ulcers Trial (SCUT) and for two laboratory strains, PA103 and PAO1.MethodsConfirmed P. aeruginosa isolates from the SCUT were divided into exoU(+) or exoU(-). The exoU(+) strains contained the gene encoding ExoU, a powerful phospholipase toxin delivered into host cells by the type three secretion system. Isolates were then assessed for susceptibility to fluoroquinolone, cephalosporin, and aminoglycoside antibiotics using disk diffusion assays. Etest was used to determine the MIC of moxifloxacin and other fluoroquinolones. Laboratory isolates in which the exoU gene was added or deleted were also tested.ResultsA significantly higher proportion of exoU(+) strains were resistant to ciprofloxacin (p = 0.001), gatifloxacin (p = 0.003), and ofloxacin (p = 0.002) compared to exoU(-) isolates. There was no significant difference between exoU(+) or exoU(-) negative isolates with respect to susceptibility to other antibiotics except gentamicin. Infections involving resistant exoU(+) strains trended towards worse clinical outcome. Deletion or acquisition of exoU in laboratory isolates did not affect fluoroquinolone susceptibility.ConclusionsFluoroquinolone susceptibility of P. aeruginosa isolated from the SCUT is consistent with previous studies showing elevated resistance involving exoU encoding (cytotoxic) strains, and suggest worse clinical outcome from infections involving resistant isolates. Determination of exoU expression in clinical isolates of P. aeruginosa may be helpful in directing clinical management of patients with microbial keratitis

Taxi Ride Based on Voice Alert System

Previous applications are not well efficient as they provide voice alerts only for the tagged locations whereas in this application voice alerts are given for any location to the user, in terms of time and distance. It would be useful even when we are out of home language/place. It is an integration of Google Maps and voice Alert. In this application, once the cab is booked it gives voice alert to the user about its current location and time it would reach the user\u27s location. This application also allows the user to know about the required nearby locations. The user can also pin any new landmark for their personal USAge into Google maps

Local Population Structure and Patterns of Western Hemisphere Dispersal for Coccidioides spp., the Fungal Cause of Valley Fever.

UnlabelledCoccidioidomycosis (or valley fever) is a fungal disease with high morbidity and mortality that affects tens of thousands of people each year. This infection is caused by two sibling species, Coccidioides immitis and C. posadasii, which are endemic to specific arid locales throughout the Western Hemisphere, particularly the desert southwest of the United States. Recent epidemiological and population genetic data suggest that the geographic range of coccidioidomycosis is expanding, as new endemic clusters have been identified in the state of Washington, well outside the established endemic range. The genetic mechanisms and epidemiological consequences of this expansion are unknown and require better understanding of the population structure and evolutionary history of these pathogens. Here we performed multiple phylogenetic inference and population genomics analyses of 68 new and 18 previously published genomes. The results provide evidence of substantial population structure in C. posadasii and demonstrate the presence of distinct geographic clades in central and southern Arizona as well as dispersed populations in Texas, Mexico, South America, and Central America. Although a smaller number of C. immitis strains were included in the analyses, some evidence of phylogeographic structure was also detected in this species, which has been historically limited to California and Baja, Mexico. Bayesian analyses indicated that C. posadasii is the more ancient of the two species and that Arizona contains the most diverse subpopulations. We propose a southern Arizona-northern Mexico origin for C. posadasii and describe a pathway for dispersal and distribution out of this region.ImportanceCoccidioidomycosis, or valley fever, is caused by the pathogenic fungi Coccidioides posadasii and C. immitis The fungal species and disease are primarily found in the American desert southwest, with spotted distribution throughout the Western Hemisphere. Initial molecular studies suggested a likely anthropogenic movement of C. posadasii from North America to South America. Here we comparatively analyze eighty-six genomes of the two Coccidioides species and establish local and species-wide population structures to not only clarify the earlier dispersal hypothesis but also provide evidence of likely ancestral populations and patterns of dispersal for the known subpopulations of C. posadasii