Reservoir computing using a delayed feedback system: towards photonic implementations

Delayed feedback systems are known to exhibit a rich dynamical behavior, showing a wide variety of dynamical regimes. We use this richness to implement reservoir computing, a processing concept in machine learning. In this paper we demonstrate the proof of principle on an electronic system, however the approach is readily transferable to photonics, promising fast and computationally efficient all-optical processing. Using only one single node with delayed feedback instead of an entire network of nodes, we succeed in obtaining state-of-the-art results on benchmarks such as spoken digit recognition and system identification

Mathematical modeling of thermal and circulatory effects during hemodialysis.

Intradialytic hypotension (IDH) is one of the most common complications of hemodialysis (HD) treatment. The initiating factor of IDH is a decrease in blood volume which is related to an imbalance between ultrafiltration (UF) and refilling rate. Impaired reactivity of resistance and capacitance vessels in reaction to hypovolemia plays possibly a major role in the occurrence of IDH. These vessels also fulfill an important function in body temperature regulation. UF induced cutaneous vasoconstriction would result in a reduced surface heat loss and an increase in core temperature. To release body heat, skin blood flow (SBF) is increased at a later stage of the HD treatment, whereby possibly IDH can occur. Aim of the study is to develop a mathematical model which can provide insight into the impact of thermoregulatory processes on the cardiovascular system during HD treatment. The mathematical procedure has been created by coupling a thermo-physiological (TP) model with a cardiovascular (CV) model to study regulation mechanisms in the human body during HD+UF. Model simulations for isothermal vs. thermoneutral HD+UF were compared to measurement data of patients on chronic intermittent HD (n=13). Core temperature during simulated HD+UF sessions increased within the range of measurement data (0.23ºC vs. 0.32±0.41ºC). The model showed a decline in mean arterial pressure (MAP) of -7% for thermoneutral HD+UF versus -4% for isothermal HD+UF after 200 minutes during which relative blood volume (RBV) changed by -13%. In conclusion, simulation results of the combined model show possibilities for predicting circulatory and thermal responses during HD+UF

Advies Onderzoek medische zorg aan ouderen. In het bijzonder ouderen met multiple en complexe problematiek

Recent heeft de Raad voor Gezondheidsonderzoek (RGO) het advies “Medisch Onderzoek voor Ouderen” uitgebracht. Het advies richt zich vooral op onderzoek naar ouderen met multiple en complexe aandoeningen, en geeft antwoord op de vraag van de minister van VWS hoe het onderzoek zou kunnen helpen de belangrijkste problemen in de geriatrische zorg op te vangen. De minister vroeg de Raad vooral aan te geven hoe het wetenschappelijk onderzoek een bijdrage zou kunnen leveren aan de kwaliteit van de medisch geriatrische zorg ongeacht door welke beroepsgroep of specialisme deze wordt geleverd. De opdracht die de Raad daarnaast van de minister ontving was te verduidelijken ‘... hoe het bestaande wetenschappelijk potentieel en inzicht beter kan worden benut en ingezet. Dus niet weer nieuw onderzoek naast al het bestaande’

Numerical investigation of semiconductor ring lasers with two external cavities

4 pages, 4 figures.-- In Proceedings Symposium IEEE/LEOS Benelux Chapter, 2008, Twente.-- PDF pre-print.We report results on the numerical analysis of the behaviour of a semiconductor ring laser under the influence of feedback from two external cavities. Double feedback arises naturally in a semiconductor ring laser, e.g. at the end facets of an outcoupling waveguide. We find that, under certain conditions, the system displays quasi-periodic and chaotic behavior.This work has been partially funded by the European Community under project IST-2005-34743 (IOLOS). This work was supported by the Belgian Science Policy Office under grant No. IAP-VI10, by the Spanish Ministry of Education (MEC) and FEDER under grants No. FIS2004-00953 (CONOCE2). GV, LG and IVE acknowledge grant and project support of the Research Foundation Flanders (FWO). IVE acknowledges advice by V. Z. Tronciu. AS acknowledges the Ramon y Cajal program by MEC.Peer reviewe

Negative diffraction pattern dynamics in nonlinear cavities with left-handed materials

We study a ring cavity filled with a slab of a right-handed material and a slab of a left-handed material. Both layers are assumed to be nonlinear Kerr media. First, we derive a model for the propagation of light in a left-handed material. By constructing a mean-field model, we show that the sign of diffraction can be made either positive or negative in this resonator, depending on the thicknesses of the layers. Subsequently, we demonstrate that the dynamical behavior of the modulation instability is strongly affected by the sign of the diffraction coefficient. Finally, we study the dissipative structures in this resonator and reveal the predominance of a two-dimensional up-switching process over the formation of spatially periodic structures, leading to the truncation of the homogeneous hysteresis cycle.Comment: 8 pages, 5 figure

Encouraging survival rates in patients with acute myocardial infarction treated with an intra-aortic balloon pump

Objective To evaluate a 30-day and long-term outcome of patients with acute myocardial infarction (AMI) treated with intra-aortic balloon pump (IABP) counterpulsation and to identify predictors of a 30-day and long-term all-cause mortality. Methods Retrospective cohort study of 437 consecutive AMI patients treated with IABP between January 1990 and June 2004. A Cox proportional hazards model was used to identify predictors of a 30-day and long-term all-cause mortality. Results Mean age of the study population was 61±11 years, 80% of the patients were male, and 68% had cardiogenic shock. Survival until IABP removal after successful haemodynamic stabilisation was 78% (n=341). Cumulative 30-day survival was 68%. Median follow-up was 2.9 years (range, 6 months to 15 years). In patients who survived until IABP removal, cumulative 1-, 5-, and 10-year survival was 75%

Ultra deep sub-kpc view of nearby massive compact galaxies

Using Gemini North telescope ultra deep and high resolution (sub-kpc) K-band adaptive optics imaging of a sample of 4 nearby (z~0.15) massive (~10^{11}M_sun) compact (R<1.5 kpc) galaxies, we have explored the structural properties of these rare objects with an unprecedented detail. Our surface brightness profiles expand over 12 magnitudes in range allowing us to explore the presence of any faint extended envelope on these objects down to stellar mass densities ~10^{6} M_sun/kpc^{2} at radial distances of ~15 kpc. We find no evidence for any extended faint tail altering the compactness of these galaxies. Our objects are elongated, resembling visually S0 galaxies, and have a central stellar mass density well above the stellar mass densities of objects with similar stellar mass but normal size in the present universe. If these massive compact objects will eventually transform into normal size galaxies, the processes driving this size growth will have to migrate around 2-3x10^{10}M_sun stellar mass from their inner (R<1.7 kpc) region towards their outskirts. Nearby massive compact galaxies share with high-z compact massive galaxies not only their stellar mass, size and velocity dispersion but also the shape of their profiles and the mean age of their stellar populations. This makes these singular galaxies unique laboratories to explore the early stages of the formation of massive galaxies.Comment: Accepted for publication in ApJ Letter. Version revised to match the accepted versio

Intradialytic protein ingestion and exercise do not compromise uremic toxin removal throughout hemodialysis

Objective Dietary protein and physical activity interventions are increasingly implemented during hemodialysis to support muscle maintenance in patients with end-stage renal disease (ESRD). Although muscle maintenance is important, adequate removal of uremic toxins throughout hemodialysis is the primary concern for patients. It remains to be established whether intradialytic protein ingestion and/or exercise modulate uremic toxin removal during hemodialysis. Methods We recruited 10 patients with ESRD (age: 65 ± 16 y, BMI: 24.2 ± 4.8 kg/m2) on chronic hemodialysis treatment to participate in this randomized cross-over trial. During hemodialysis, patients were assigned to ingest 40 g protein or a nonprotein placebo both at rest (protein [PRO] and placebo [PLA], respectively) and following 30 min of exercise (PRO + exercise [EX] and PLA + EX, respectively). Blood and spent dialysate samples were collected throughout hemodialysis to assess reduction ratios and removal of urea, creatinine, phosphate, cystatin C, and indoxyl sulfate. Results The reduction ratios of urea and indoxyl sulfate were higher during PLA (76 ± 6% and 46 ± 9%, respectively) and PLA + EX interventions (77 ± 5% and 45 ± 10%, respectively) when compared to PRO (72 ± 4% and 40 ± 8%, respectively) and PRO + EX interventions (73 ± 4% and 43 ± 7%, respectively; protein effect: P = .001 and P = .023, respectively; exercise effect: P = .25 and P = .52, respectively). Nonetheless, protein ingestion resulted in greater urea removal (P = .046) during hemodialysis. Reduction ratios and removal of creatinine, phosphate, and cystatin C during hemodialysis did not differ following intradialytic protein ingestion or exercise (protein effect: P > .05; exercise effect: P>.05). Urea, creatinine, and phosphate removal were greater throughout the period with intradialytic exercise during PLA + EX and PRO + EX interventions when compared to the same period during PLA and PRO interventions (exercise effect: P = .034, P = .039, and P = .022, respectively). Conclusion The removal of uremic toxins is not compromised by protein feeding and/or exercise implementation during hemodialysis in patients with ESRD

Stronger induction of trained immunity by mucosal BCG or MTBVAC vaccination compared to standard intradermal vaccination

Vierboom et al. demonstrate the induction of trained immunity in blood and bone marrow monocytes after vaccination with live attenuated TB vaccines in nonhuman primates. Mucosal respiratory delivery of BCG or MTBVAC induces trained immunity more efficiently compared to standard intradermal vaccination