356 research outputs found
A Decisive Role of [18F] Fdg PET/CT for Diagnosis of Neoplastic Vascular Thrombosis: Report of A Case
The combined use of PET scan with CT and fluorodeoxyglucose ([18F]FDG) can modify, in selected oncologic patients, the clinical management and care. We report here the case of a 63-year old female who showed increase serum level of CEA 3 years following left colectomy for cancer. Ultrasound and CT (computed tomography) of the abdomen showed a single lesion in the segment II of the liver with portal thrombosis. [18F] FDG PET/CT revealed two lesions (the first area was histologically proven to be a colorectal carcinoma metastasis, the second one corresponded to the portal thrombosis). No antithrombotic drugs were administered and patient underwent chemotherapy for 4 courses (eloxatin plus 5-fluorouracil anf leucovorin). Liver resection was performed 2 weeks after the end of chemotherapy, and intraoperative ultrasound revealed a normal portal flow
Socio-demographic characteristics and cognitive performance in oldest old subjects asking for driving license renewal
Background: No papers have examined the relationship between socio-demographic characteristics and cognitive performance in oldest old subjects (i.e, > = 80 years old) asking for driving license renewal. We hypothesize that, even in this highly functioning population, age, sex, and education influence cognitive performance, expressed as total or single domain (raw) test scores. This research question allows to describe, identify, and preserve independence of subjects still able to drive safely.
Methods: We examined cross-sectionally a cohort of > = 80 years old subjects (at enrollment) asking for driving license renewal in the Milan area, Italy, 2011\u20132017. The analysis was restricted to 3378 first and 863 second visits where individual\u2019s cognitive performance was evaluated. According to the study protocol, the Mini Mental State Examination (MMSE) test was administered at the first visit for driving license renewal and the Montreal Cognitive Assessment (MoCA) test at the second visit, following an additional renewal request. Ordinary least squares regression models were fitted at either time points. In each model, we included age, sex, and education as independent variables, whereas the dependent variable was total or single domain score for either test. In total, we fitted 15 regression models to assess our research hypothesis.
Results: The median subject in our sample reached the maximum scores on domains targeting operational and tactical abilities implied in safe driving, but had sub-optimal scores in the long-term memory domain included among the strategic abilities. In multiple models, being > = 87 (versus 80- < 86 years old) significantly decreased the mean total and memory scores of MMSE, but not those of the MoCA. Females (versus males) had significantly higher mean total and long-term memory scores of either tests, but not other domains. Mean total and single domain scores increased for increasing education levels for either tests, with increments for high school graduates being ~ 2 of those with (at most) a junior high school diploma.Conclusions: Sex and education, as well as age to a lesser extent, predict cognitive functioning in our oldest old population, thus confirming that concepts like cognitive reserve and successful ageing are valuable constructs in the identification of older subjects still able to drive
Intensified ChlVPP/ABVVP chemotherapy regimen and pegfilgrastim support in advanced Hodgkin lymphoma
We present feasibility, toxicity and efficacy results of an intensified six-cycle ChlVPP/ABVVP regimen in advanced Hodgkin lymphoma (HL). From February 2004 to August 2007, 82 consecutive eligible patients were enrolled. According to the Hasenclever index, 64 patients (78%) were considered at low risk, 15 (18%) at intermediate and 3 (4%) at high risk. The most relevant toxicity was haematological: grade 3–4 neutropenia occurred in 32% of patients, grade 3–4 anaemia in 26% of patients. Severe infections and febrile neutropenia were observed in 8% of patients. With a median follow-up of 35 months (range 12–55), the three-year freedom from treatment failure (FFTF) and overall survival (OS) were 75% (95% CI 65%–86%) and 94% (95% CI 87%–99%), respectively. The intensified ChlVPP/ABVVP regimen in advanced HL is effective, does not seem to differ from standard regimens in terms of FFTF and OS and showed a favourable toxicity profile
Exotic lagomorph may influence eagle abundances and breeding spatial aggregations: A field study and meta- analysis on the nearest neighbor distance
The introduction of alien species could be changing food source composition, ultimately restructuring demography and spatial distribution of native communities. In Argentine Patagonia, the exotic European hare has one of the highest numbers recorded worldwide and is now a widely consumed prey for many predators. We examine the potential relationship between abundance of this relatively new prey and the abundance and breeding spacing of one of its main consumers, the Black-chested Buzzard-Eagle (Geranoaetus melanoleucus). First we analyze the abundance of individuals of a raptor guild in relation to hare abundance through a correspondence analysis. We then estimated the Nearest Neighbor Distance (NND) of the Black-chested Buzzard-eagle abundances in the two areas with high hare abundances. Finally, we performed a metaregression between the NND and the body masses of Accipitridae raptors, to evaluate if Black-chested Buzzard-eagle NND deviates from the expected according to their mass. We found that eagle abundance was highly associated with hare abundance, more than with any other raptor species in the study area. Their NND deviates from the value expected, which was significantly lower than expected for a raptor species of this size in two areas with high hare abundance. Our results support the hypothesis that high local abundance of prey leads to a reduction of the breeding spacing of its main predator, which could potentially alter other interspecific interactions, and thus the entire community.Fil: Barbar, Facundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigaciones en Biodiversidad y Medioambiente. Universidad Nacional del Comahue. Centro Regional Universidad Bariloche. Instituto de Investigaciones en Biodiversidad y Medioambiente; ArgentinaFil: Ignazi, Gonzalo Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigaciones en Biodiversidad y Medioambiente. Universidad Nacional del Comahue. Centro Regional Universidad Bariloche. Instituto de Investigaciones en Biodiversidad y Medioambiente; ArgentinaFil: Hiraldo, Fernando. Consejo Superior de Investigaciones Científicas. Estación Biológica de Doñana; EspañaFil: Lambertucci, Sergio Agustin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigaciones en Biodiversidad y Medioambiente. Universidad Nacional del Comahue. Centro Regional Universidad Bariloche. Instituto de Investigaciones en Biodiversidad y Medioambiente; Argentin
EP-1082: Interim 18F-FDG-PET/CT during chemoradiotherapy for early outcome prediction of head and neck cancer
The effects of sex, age, season and habitat on diet of the red fox Vulpes vulpes in northeastern Poland
The diet of the red fox Vulpes vulpes was investigated in five regions of northeastern Poland by stomach content analysis of 224 foxes collected from hunters. The red fox is expected to show the opportunistic feeding habits. Our study showed that foxes preyed mainly on wild prey, with strong domination of Microtus rodents, regardless of sex, age, month and habitat. Voles Microtus spp. were found in 73% of stomachs and constituted 47% of food volume consumed. Other food items were ungulate carrion (27% of volume), other mammals (11%), birds (9%), and plant material (4%). Sex- and age-specific differences in dietary diversity were found. Adult males and juvenile foxes had larger food niche breadths than adult females and their diets highly overlapped. Proportion of Microtus voles increased from autumn to late winter. Significant habitat differences between studied regions were found. There was a tendency among foxes to decrease consumption of voles with increasing percentage of forest cover. Based on our findings, red foxes in northeastern Poland can be recognized as a generalist predators, consuming easily accessible and abundant prey. However, high percentage of voles consumed regardless of age, sex, month, or habitats may indicate red fox specialization in preying on Microtus rodents
A 3‐Year Sample of Almost 1,600 Elves Recorded Above South - America by the Pierre Auger Cosmic‐Ray Observatory
Measurement of the fluctuations in the number of muons in extensive air showers with the Pierre Auger Observatory
We present the first measurement of the fluctuations in the number of muons
in extensive air showers produced by ultra-high energy cosmic rays. We find
that the measured fluctuations are in good agreement with predictions from air
shower simulations. This observation provides new insights into the origin of
the previously reported deficit of muons in air shower simulations and
constrains models of hadronic interactions at ultra-high energies. Our
measurement is compatible with the muon deficit originating from small
deviations in the predictions from hadronic interaction models of particle
production that accumulate as the showers develop.Comment: Accepted for publication in PR
Design, upgrade and characterization of the silicon photomultiplier front-end for the AMIGA detector at the Pierre Auger Observatory
AMIGA (Auger Muons and Infill for the Ground Array) is an upgrade of the
Pierre Auger Observatory to complement the study of ultra-high-energy cosmic
rays (UHECR) by measuring the muon content of extensive air showers (EAS). It
consists of an array of 61 water Cherenkov detectors on a denser spacing in
combination with underground scintillation detectors used for muon density
measurement. Each detector is composed of three scintillation modules, with 10
m detection area per module, buried at 2.3 m depth, resulting in a total
detection area of 30 m. Silicon photomultiplier sensors (SiPM) measure the
amount of scintillation light generated by charged particles traversing the
modules. In this paper, the design of the front-end electronics to process the
signals of those SiPMs and test results from the laboratory and from the Pierre
Auger Observatory are described. Compared to our previous prototype, the new
electronics shows a higher performance, higher efficiency and lower power
consumption, and it has a new acquisition system with increased dynamic range
that allows measurements closer to the shower core. The new acquisition system
is based on the measurement of the total charge signal that the muonic
component of the cosmic ray shower generates in the detector.Comment: 40 pages, 33 figure
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