Fano versus Kondo Resonances in a Multilevel "Semi-Open" Quantum Dot

Linear conductance across a large quantum dot via a single level e_0 with large hybridization to the contacts is strongly sensitive to quasi-bound states localized in the dot and weakly coupled to e_0. It oscillates with the gate voltage due to interference of the Fano type. At low temperature and Coulomb blockade, Kondo correlations damp the oscillations on an extended range of gate voltage values, by freezing the occupancy of the e_0 level itself. As a consequence, antiresonances of Fano origin are washed out. The results are in good correspondence with experimental data for a large quantum dot in the semi-open regime.Comment: 4 eps figures, RevTex format, revised version, to appear in Phys. Rev. Letter

On Type IIA geometries dual to N = 2 SCFTs

We provide explicit solutions of Type IIA supergravity which are believed to be dual to N = 2 superconformal four dimensional gauge theories. These explicit solutions are based on the general ansatz for such a type of backgrounds introduced by Gaiotto and Maldacena.Comment: 23 pages, 10 figures; minor corrections, references correcte

Open Semiclassical Strings and Long Defect Operators in AdS/dCFT Correspondence

We consider defect composite operators in a defect superconformal field theory obtained by inserting an AdS_4 x S^2-brane in the AdS_5 x S^5 background. The one-loop dilatation operator for the scalar sector is represented by an integrable open spin chain. We give a description to construct coherent states for the open spin chain. Then, by evaluating the expectation value of the Hamiltonian with the coherent states in a long operator limit, a Landau-Lifshitz type of sigma model action is obtained. This action is also derived from the string action and hence we find a complete agreement in both SYM and string sides. We see that an SO(3)_H pulsating string solution is included in the action and its energy completely agrees with the result calculated in a different method. In addition, we argue that our procedure would be applicable to other AdS-brane cases.Comment: 22 pages, 1 figure, LaTeX, minor corrections and references added. v3) some new results added. shortened and accepted version in PR

Superstring Scattering from O-planes

We write the vertex operators of massless NS-NS and RR states of Type II superstring theory in the presence of Orientifold p-planes. They include the usual vertex operators of Type II theory and their images. We then calculate the two-point functions of these vertex operators at the projective plane PR_2 level. We show that the result can be written in the Veneziano-type formulae, with the same kinematic factor that appears in the D_p-branes amplitudes. While the scattering amplitudes with the usual vertex operators are not gauge invariant, the above amplitudes are invariant. From the amplitude describing scattering of two NS-NS states off the O-plane, we find the low energy effective action of O-planes. The result shows a relative factor 2^{p-6} between couplings to O-planes and to D-branes at (\alpha')^2 order.Comment: 22 pages, no figure, latex file, v2: minor corrections, version to appear in Nucl. Phys.

Causal effects of PetroCaribe on sustainable development: a synthetic control analysis

We examine the causal effects of the energy subsidy programme PetroCaribe in the three dimensions of sustainable development: economic, social and environmental. We use the synthetic control method to construct a counterfactual and compare it to the outcomes of the beneficiary countries and thus estimate the magnitude and direction of the PetroCaribe effect. PetroCaribe had a positive effect on economic growth in most of the beneficiary countries; however, this economic boost was not followed by an improvement in social development. Environmentally, PetroCaribe did not negatively or positively impact the environmental quality of the member countries, in the sense that we do not find a significant effect on the trend of urn:x-wiley:14636786:media:manc12275:manc12275-math-0001 emissions per capita

Simultaneous Inference in General Parametric Models

Simultaneous inference is a common problem in many areas of application. If multiple null hypotheses are tested simultaneously, the probability of rejecting erroneously at least one of them increases beyond the pre-specified significance level. Simultaneous inference procedures have to be used which adjust for multiplicity and thus control the overall type I error rate. In this paper we describe simultaneous inference procedures in general parametric models, where the experimental questions are specified through a linear combination of elemental model parameters. The framework described here is quite general and extends the canonical theory of multiple comparison procedures in ANOVA models to linear regression problems, generalized linear models, linear mixed effects models, the Cox model, robust linear models, etc. Several examples using a variety of different statistical models illustrate the breadth of the results. For the analyses we use the R add-on package multcomp, which provides a convenient interface to the general approach adopted here

APC loss in breast cancer leads to doxorubicin resistance via STAT3 activation

Resistance to chemotherapy is one of the leading causes of death from breast cancer. We recently established that loss of Adenomatous Polyposis Coli (APC) in the Mouse Mammary Tumor Virus – Polyoma middle T (MMTV-PyMT) transgenic mouse model results in resistance to cisplatin or doxorubicin-induced apoptosis. Herein, we aim to establish the mechanism that is responsible for APC-mediated chemotherapeutic resistance. Our data demonstrate that MMTV-PyMT;ApcMin/+ cells have increased signal transducer and activator of transcription 3 (STAT3) activation. STAT3 can be constitutively activated in breast cancer, maintains the tumor initiating cell (TIC) population, and upregulates multidrug resistance protein 1 (MDR1). The activation of STAT3 in the MMTV-PyMT;ApcMin/+ model is independent of interleukin 6 (IL-6); however, enhanced EGFR expression in the MMTV-PyMT;ApcMin/+ cells may be responsible for the increased STAT3 activation. Inhibiting STAT3 with a small molecule inhibitor A69 in combination with doxorubicin, but not cisplatin, restores drug sensitivity. A69 also decreases doxorubicin enhanced MDR1 gene expression and the TIC population enhanced by loss of APC. In summary, these results have revealed the molecular mechanisms of APC loss in breast cancer that can guide future treatment plans to counteract chemotherapeutic resistance

Two-loop AdS_5 x S^5 superstring: testing asymptotic Bethe ansatz and finite size corrections

We continue the investigation of two-loop string corrections to the energy of a folded string with a spin S in AdS_5 and an angular momentum J in S^5, in the scaling limit of large J and S with ell=pi J/(lambda^(1/2) ln S)=fixed. We compute the generalized scaling function at two-loop order f_2(ell) both for small and large values of ell matching the predictions based on the asymptotic Bethe ansatz. In particular, in the small ell expansion, we derive an exact integral form for the ell-dependent coefficient of the Catalan's constant term in f_2(ell). Also, by resumming a certain subclass of multi-loop Feynman diagrams we obtain an exact expression for the leading (ln ell) part of f(lambda^(1/2), ell) which is valid to any order in the alpha'~1/lambda^(1/2) expansion. At large ell the string energy has a BMN-like expansion and the first few leading coefficients are expected to be the same at weak and at strong coupling. We provide a new example of this non-renormalization for the term which is generated at two loops in string theory and at one-loop in gauge theory (sub-sub-leading in 1/J). We also derive a simple algebraic formula for the term of maximal transcendentality in f_2(ell) expanded at large ell. In the second part of the paper we initiate the study of 2-loop finite size corrections to the string energy by formally compactifying the spatial world-sheet direction in the string action expanded near long fast-spinning string. We observe that the leading finite-size corrections are of "Casimir" type coming from terms containing at least one massless propagator. We consider in detail the one-loop order (reproducing the leading Landau-Lifshitz model prediction) and then focus on the two-loop contributions to the (1/ln S) term (for J=0). We find that in a certain regularization scheme used to discard power divergences the two-loop coefficient of the (1/ln S) term appears to vanish.Comment: 50 pages, 4 figures v2: typos corrected, references adde

Semiclassical Strings on AdS_5 x S^5/Z_M and Operators in Orbifold Field Theories

We show agreements, at one-loop level of field theory, between energies of semiclassical string states on AdS_5 x S^5/Z_M and anomalous dimensions of operators in N=0,1,2 orbifold field theories originating from N=4 SYM. On field theory side, one-loop anomalous dimension matrices can be regarded as Hamiltonians of spin chains with twisted boundary conditions. These are solvable by Bethe ansatz. On string side, twisted sectors emerge and we obtain some string configurations in twisted sectors. In SU(2) subsectors, we compare anomalous dimensions with string energies and see agreements. We also see agreements between sigma models of both sides in SU(2) and SU(3) subsectors.Comment: LaTeX, 23 pages, 4 figures; v2 minor corrections, added references; v3 typos corrected, published versio