Study to define unsteady flow fields and their statistical characteristics

Preliminary estimates of space shuttle fluctuating pressure environments were made based on analyses of wind tunnel data, and empirical prediction techniques. Particular emphasis was given to the external tank and solid rocket boosters for the transonic speed regime during launch of a parallel-burn space shuttle configuration. Predicted environments are presented as space-averaged zonal profiles with progressive shading from zone to zone to illustrate spatial variations in the magnitude of the fluctuating pressure coefficient over the surfaces of the external tank and solid rocket boosters. Predictions are provided for the transonic Mach number range from 0.8 equal to or less than M sub infinity equal to or less than 1.5, and for supersonic Mach numbers of 2.0 and 3.0

Analysis of screeching in a cold flow jet experiment

The screech phenomenon observed in a one-sixtieth scale model space shuttle test of the solid rocket booster exhaust flow noise has been investigated. A critical review is given of the cold flow test data representative of Space Shuttle launch configurations to define those parameters which contribute to screech generation. An acoustic feedback mechanism is found to be responsible for the generation of screech. A simple equation which permits prediction of screech frequency in terms of basic testing parameters such as the jet exhaust Mach number and the separating distance from nozzle exit to the surface of model launch pad is presented and is found in good agreement with the test data. Finally, techniques are recommended to eliminate or reduce the screech

Mathematical Surfaces and 3D Printing

https://scholarworks.moreheadstate.edu/student_scholarship_posters/1009/thumbnail.jp

Short-range forces due to Lorentz-symmetry violation

Complementing previous theoretical and experimental work, we explore new types of short-range modifications to Newtonian gravity arising from spacetime-symmetry breaking. The first non-perturbative, i.e., to all orders in coefficients for Lorentz-symmetry breaking, are constructed in the Newtonian limit. We make use of the generic symmetry-breaking terms modifying the gravity sector and examine the isotropic coefficient limit. The results show new kinds of force law corrections, going beyond the standard Yukawa parameterization. Further, there are ranges of the values of the coefficients that could make the resulting forces large compared to the Newtonian prediction at short distances. Experimental signals are discussed for typical test mass arrangements.Comment: 33 pages, 8 color figure

Reimagining the Path of an Unmatched Orthopaedic Residency Application: A Survey of Program Directors

BACKGROUND: Few evidence-based suggestions are available to help applicants and mentors improve reapplication outcomes. We sought to provide program directors\u27 (PDs) perspectives on actionable steps to improve reapplicants\u27 chances for a match. METHODS: The PDs were asked to rank positions unmatched applicants can pursue, steps these applicants can take for the next application cycle, and reasons why reapplicants do not match. RESULTS: Responses from 66 of 123 PDs were received (53.6% response rate). Obtaining new recommendation letters and rotating with orthopaedics were the highest 20 ranked steps unmatched applicants can take. No curriculum vitae (CV) improvement, poor interview, and poor letters of recommendation were the most important reasons hindering applicants from matching when reapplying. CONCLUSIONS: Steps reapplicants could prioritize include obtaining new recommendation letters, rotating in orthopaedics, and producing new research items. CV strengthening and improving interview skills address the 2 main reasons why unmatched applicants failed in subsequent attempts. LEVEL OF EVIDENCE: Level IV

Activation of HuR downstream of p38 MAPK promotes cardiomyocyte hypertrophy

The RNA binding protein Human antigen R (HuR) interacts with specific AU-rich domains in target mRNAs and is highly expressed in many cell types, including cardiomyocytes. However, the role of HuR in cardiac physiology is largely unknown. Our results show that HuR undergoes cytoplasmic translocation, indicative of its activation, in hypertrophic cardiac myocytes. Specifically, HuR cytoplasmic translocation is significantly increased in NRVMs (neonatal rat ventricular myocytes) following treatment with phenylephrine or angiotensin II, agonists of two independent Gαq-coupled GPCRs known to induce hypertrophy. This Gq-mediated HuR activation is dependent on p38 MAP kinase, but not canonical Gq-PKC signaling. Furthermore, we show that HuR activation is necessary for Gq-mediated hypertrophic growth of NRVMs as siRNA-mediated knockdown of HuR inhibits hypertrophy as measured by cell size and expression of ANF (atrial natriuretic factor). Additionally, HuR overexpression is sufficient to induce hypertrophic cell growth. To decipher the downstream mechanisms by which HuR translocation promotes cardiomyocyte hypertrophy, we assessed the role of HuR in the transcriptional activity of NFAT (nuclear factor of activated T cells), the activation of which is a hallmark of cardiac hypertrophy. Using an NFAT-luciferase reporter assay, we show an acute inhibition of NFAT transcriptional activity following pharmacological inhibition of HuR. In conclusion, our results identify HuR as a novel mediator of cardiac hypertrophy downstream of the Gq-p38 MAPK pathway, and suggest modulation of NFAT activity as a potential mechanism

Initial Management of Meningiomas: Analysis of the National Cancer Database

BACKGROUND: Meningiomas are the most common central nervous system tumor. We describe current trends in treatment and survival using the largest cancer dataset in the United States. METHODS: We analyzed the National Cancer Database from 2004 to 2014, for all patients with diagnosis of meningioma. RESULTS: 201,765 cases were analyzed. Patients were most commonly White (81.9%) females (73.2%) with a median age of 64 years. Fifty percent of patients were diagnosed by imaging. Patients were reported as grade I (24.9%), grade II (5.0%), grade III (0.7%), or unknown WHO grade (69.4%). Patients diagnosed by imaging were older, received treatment in community facilities, had higher Charlson-Deyo score, and a lower rate of private insurance. Watchful waiting was the most common treatment modality (46.7%), followed by surgery only (40%). Grade II and III patients were more likely to receive therapy. Watchful waiting increased from 35.2% in 2004 to 51.4% in 2014. Younger age, male gender, private insurance, and treatment in academic facilities were determinants for receipt of surgery and/or radiation. Median survival was 12.6 years, higher in histologically confirmed cases (13.1 years). Older patients, Blacks, males, those that received radiation plus surgery, and were treated in community facilities had an increased risk of mortality. CONCLUSIONS: Over half of patients were diagnosed by imaging, suggesting a higher role of clinical determinants over histological confirmation in treatment decisions. Watchful waiting as initial management is increasing. Our survival analysis favored histological confirmation. Patients receiving radiation and surgery had an increased risk of mortality