Cooperative Activities to Reduce Aggression in Young Children

I investigated the effect of introducing cooperative games during recess to reduce aggressive behaviors in preschool-age children. The action research was done at an intentionally culturally and socio-economically diverse Montessori school in St. Paul, Minnesota. The 23 children involved were all children from the three to six age group who take daily naps. I recorded every aggressive incident I saw before, during, and after the intervention. I also recorded what cooperative activities I introduced for the intervention. Once before and after the intervention I asked the children if they enjoyed recess. I recorded observational notes such as weather conditions, and what activities the children chose each day. The data did not show that the cooperative games had a significant effect on the number of aggressive incidents recorded. Many more boys than girls were involved in aggressive incidents. There was no significant change in how the children reported their enjoyment of recess. Aggressive behavior could possibly be reduced through another action research project with a longer intervention period, a conflict resolution plan, and more purposeful activities for the children outside

Rent Seeking in Elite Networks

We employ a unique dataset on members of an elite service club in Germany to investigate how social connections in elite networks affect the allocation of resources. Specifically, we investigate credit allocation decisions of banks to firms inside the network. Using a quasi-experimental research design, we document misallocation of bank credit inside the network, with bankers with weakly aligned incentives engaging most actively in crony lending. Our findings, thus, resonate with existing theories of elite networks as rent extractive coalitions that stifle economic prosperity

A 0535+26 in the August/September 2005 outburst observed by RXTE and INTEGRAL

In this Letter we present results from INTEGRAL and RXTE observations of the spectral and timing behavior of the High Mass X-ray Binary A 0535+26 during its August/September 2005 normal (type I) outburst with an average flux F(5-100keV)~400mCrab. The search for cyclotron resonance scattering features (fundamental and harmonic) is one major focus of the paper. Our analysis is based on data from INTEGRAL and RXTE Target of Opportunity Observations performed during the outburst. The pulse period is determined. X-ray pulse profiles in different energy ranges are analyzed. The broad band INTEGRAL and RXTE pulse phase averaged X-ray spectra are studied. The evolution of the fundamental cyclotron line at different luminosities is analyzed. The pulse period P is measured to be 103.39315(5)s at MJD 53614.5137. Two absorption features are detected in the phase averaged spectra at E_1~45keV and E_2~100keV. These can be interpreted as the fundamental cyclotron resonance scattering feature and its first harmonic and therefore the magnetic field can be estimated to be B~4x10^12G.Comment: 4 pages, 5 figures, accepted for publication in A&A Letter

Body composition and cartilage biomarkers are affected by diet in growing large breed dogs

The purpose of this study was to describe cartilage and bone biochemical markers and body composition in growing large breed dogs and to determine if these masurements are affected by diets of similar caloric density but differing composition

Temporal and regional intestinal changes in permeability, tight junction, and cytokine gene expression following ovariectomy-induced estrogen deficiency

The work presented within this study was funded in part by NCCIH (R01AT007695) and NIDDK (R01DK101050Peer reviewedPublisher PD

Calmodulin Interaction with hEAG1 Visualized by FRET Microscopy

BACKGROUND: Ca(2+)-mediated regulation of ion channels provides a link between intracellular signaling pathways and membrane electrical activity. Intracellular Ca(2+) inhibits the voltage-gated potassium channel EAG1 through the direct binding of calmodulin (CaM). Three CaM binding sites (BD-C1: 674-683, BD-C2: 711-721, BD-N: 151-165) have been identified in a peptide screen and were proposed to mediate binding. The participation of the three sites in CaM binding to the native channel, however, remains unclear. METHODOLOGY/PRINCIPAL FINDINGS: Here we studied the binding of Ca(2+)/CaM to the EAG channel by visualizing the interaction between YFP-labeled CaM and Cerulean-labeled hEAG1 in mammalian cells by FRET. The results of our cellular approach substantiate that two CaM binding sites are predominantly involved; the high-affinity 1-8-14 based CaM binding domain in the N-terminus and the second C-terminal binding domain BD-C2. Mutations at these sites completely abolished CaM binding to hEAG1. CONCLUSIONS/SIGNIFICANCE: We demonstrated that the BD-N and BD-C2 binding domains are sufficient for CaM binding to the native channel, and, therefore, that BD-C1 is unable to bind CaM independently