Serological diagnosis of pulmonary aspergillosis

Methods for the preparation of antigens from clinically isolated cultures of Aspergillus were standardized. Sera from 25 suspected cases of pulmonary aspergillosis were tested against antigens prepared by us, from 4 strains of A. fumigatus and one strain of A. flavus, using the Ouchterlony double diffusion and immunoelectrophoretic techniques. Of the 25 sera tested, 18 reacted positively with antigens of A.fumigatus, one with A.flavus and 2 with both these species. Antigens of two non-pathogenic Aspergilli included in the study failed to react with any of the sera. Our antigen preparations gave more numerous as well as sharper precipitin lines than the commercial Bencard antigens which were used for comparison. Moreover, mycelial antigens from 48 to 96 h old cultures revealed precipitin lines comparable to that of the routine, 4 week old culture filtrate antigens, thus suggesting that the incubation period for obtaining antigens could be cut down considerably

Experimental Study of Perforated Pin Fins with Perforations around the Circumference of the Fins

Nine fins with inline arrangement and eight fins in staggered arrangement with each fin having the diameter of 16 mm and the perforation diameter of 3 mm are modeled to study the heat transfer performance. The Nusselt number for staggered perforated fins is obtained in the range of 90 to 235 while for solid pin fins in the similar arrangement, obtained in the range of 80 to 220 with Reynolds number in the range of 15000 to 82,000. The convective heat transfer coefficient in case of perforated fins with staggered arrangement is obtained in the range of 25 to 60 W/m2K while for solid pin fins, it in the range of 20 to 50 W/m2K. Overall analysis showed perforated pin fins with staggered arrangement performed better in terms of heat transfer as compared sold pin fins

Synthesis, spectral characterization and some biological studies of transition metal complexes with Schiff base ligand containing N,O and S as donor atoms

Transition metal complexes of Cu(II), Co(II), Ni(II), Zn(II), Cd(II) and Mn(II) have been synthesized with the Schiff base ligand 5-Sub-N-(2-mercaptophenyl)salicylideneimine. Elemental analysis of these complexes suggest that these metal ions forms complexes of type ML(H2O)stoichiometry for Cu(II), Co(II), Ni(II), Zn(II), Cd(II) and Mn(II). The ligand behaves as tridentate and forms coordinate bonds through O, S and N atoms. Magnetic susceptibility, IR, UV – Visible, Mass and ESR spectral studies suggest that Cu(II), Ni(II) complexes posses square planar geometry, whereas Co(II), Zn(II), Cd(II) and Mn(II) complexes posses tetrahedral geometry. The complexes were tested for their antimicrobial activity against the bacterial strains Staphylococcus aureus and Bacillus subtilis.The Schiff base metal complexes evaluated for their antifungal activity against the fungi A. niger and C. oxysporum. The DNA cleavage studies of Schiff base complexes werestudied using Calf – Thymus DNA by agarose gel electrophoresis method

The Mn(II), Co(II), Ni(II) and Cu(II) complexes of (Z)-N'((1H-indol-3-yl)methylene)nicotinohydrazide Schiff base: synthesis, characterization and biological evaluation

Schiff bases being biological moieties possess diverse biological and pharmaceutical applications. Metal ions play an important role in various functions of the biological system as well as the human body. The importance of Schiff base and their metal complexes have been acknowledged in the field of bioinorganic chemistry. The current investigation hence focuses on the synthesis and characterization of a bidentate indole-based ligand(Z)-N'((1H-indol-3-yl)methylene)nicotinohydrazide (L) derived from indole-3-carboxaldehyde (1), nicotinic acid hydrazide (2) and their metal complexes of Mn(II), Co(II), Ni(II) and Cu(II), (4a-d) in 2:1 stichiometric ratio. All the synthesized ligand and complexes were characterized by IR, UV-Visible, H-1 NMR, C-13 NMR, Mass, Powder XRD analysis. Further, the ligand and their metal complexes were screened for antimicrobial, antioxidant and DNA cleavage studies. Among the synthesized complexes, Ni(II) (4c) showed highest antimicrobial activity against tested Gram -ve and Gram +ve bacterial strains and fungal microorganism, better than the ligand (L). The antioxidant activity results showed that the metal complexes (4a-d) were observed to be more active than the parent ligand. Furthermore, the ligand (L) and their respective metal (II) complexes (4a-d) were found to cleave the pBR322 DNA, during gel electrophoresis studies

A six-year study of leiomyomata with emphasis on lipoleiomyoma

Background: Leiomyoma is the most common benign neoplasm of the uterus. Lipoleiomyoma is a rare variant usually affecting women in the postmenopausal age group. Incidence of lipoleiomyoma varies from 0.59% - 2.1%. This study was undertaken to analyse the different variants, degenerative changes and to determine the incidence, clinical and morphological features of lipoleiomyoma amongst all the leiomyomas studied.Methods: This study was done in the Department of Pathology over a period of 6 years. Authors studied 575 patients with leiomyoma constituting a total of 1122 leiomyomata as some patients presented with multiple leiomyomata. Further clinicopathological correlation was done.Results: In the present study 98.03% of leiomyomata were uterine in location, 1.06% were cervical, 0.62% were in broad ligament and 0.26 % were in ovary. Among the 1122 leiomyomata studied, degenerative changes were noted in 19.6% of which hyaline degeneration was the most common. Leiomyoma variants constituted 5.27% of all leiomyomata. The incidence of lipoleiomyoma was 0.71% with size ranging from 3-10cm.Conclusions: Leiomyoma is a common tumor of the uterus and lipoleiomyoma variant is very uncommon with unknown etiology. They occur in postmenopausal as well as reproductive age group. The site of lipoleiomyoma can be uterine or extrauterine location such as broad ligament. Coexistance of metabolic derangement is an observation that may have a role in development of lipoleiomyoma

Statistical Analysis and Deep Learning Associated Modeling for Early stage Detection of Carinoma

The high death rate and overall complexity of the cancer epidemic is a global health crisis. Progress in cancer prediction based on gene expression has increased in light of the speedy advancement using modern high-throughput sequencing methods and a wide range of machine learning techniques, bringing insights into efficient and precise treatment decision-making. Therefore, it is of significant interest to create machine learning systems that accurately identify cancer patients and healthy people. Although several classification systems have been applied to cancer prediction, no single strategy has proven superior. This research shows how to apply deep learning to an optimization method that uses numerous machine learning models. Statistical analysis has helped us choose informative genes, and we've been feeding those to five different categorization models. The results from the five different classifiers are ensembled in the next step using a deep learning technique. The three most common types of adenocarcinoma are those of the lungs, stomach, and breasts. The suggested deep learning-based inter-ensembles model was tested with deep learning-based algorithms on Carcinoma data. The results of the tests show that relative to using only one set of classifiers or the simple consensus algorithm, it improves the precision of cancer prognosis in every analyzed carcinoma dataset. The suggested deep learning-based inter-ensemble approach is demonstrated to be reliable and efficient for cancer diagnosis by entirely using diverse classifiers

Test-Tube Fertilization in dicranostigma franchetianum (Prain) Fedde

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Sinus Bradyarrhythmia in Accidental Kodo Millet (Paspalum scrobiculatum) Poisoning – A Case Report

Introduction: The Kodo Millet crop is known by different names in different regions such as Varagu, Harka and Arikelu. It is predominantly grown in India and commonly consumed. When infected by certain fungus species, the compound cyclopiazonic acid causes the crop to be toxic to humans. Case Report: The following article discusses a case of Kodo Millet poisoning, which is presented with episodes of vomiting, sweating, giddiness and dysphagia. Upon examination, Sinus bradycardia and hypotension were the major findings. The electrocardiograph (ECG) showed sinus brady arrhythmia, which is rarely presented in Kodo Millet poisoning. The emergency physician team treated the patient symptomatically and he was discharged after 24 hours as the symptoms and the ECG findings were reverted. Discussion: Kodo Millet poisoning often occurs due to accidental consumption of infected crops. Its occurrence is rare and the treatment involves only supportive care and monitoring. However, it is important to rule it out as a possible differential diagnosis in similar cases due to other causes.  Conclusion: Sinus bradyarrhythmia is a rare condition associated with Kodo Millet poisoning. Emergency physicians should be aware of this toxicity to rule out all other possible differential diagnoses and to provide patients with early treatment