STANDARDISATION OF POLYHERBAL DRUGS-CERVILON AND LUMBATON CAPSULES

Standardization of Ayurvedic formulations is an important step for the establishment of a consistent biological activity, a consistent chemical profile, or simply a quality assurance program for production and manufacturing of herbal drugs. This article reports on polyherbal drugs Cervilon and Lumbaton soft gel capsule is an effective herbal Indian Ayurvedic medicine used for the neck pain and skeleto-muscular problems such as cervical spondylosis, cervical injuries, lumbar spondylosis, lower back pain, sciatica, numbness. Samples were collected from AVN Ayurveda formulations (P) Ltd. Madurai. The drugs has been standardised on the basis of physio-chemical parameters, antifungal and antimicrobial activity. High performance thin layer chromatography [HPTLC] fingerprint profiles were carried out to analysis the identity, purity and strength of the drugs. The chemical parameter analyses such as Acid value, Saponification value, Peroxide value, Iodine value are calculated and it was observed that all the values within the limits. Preliminary phytochemical analysis of the methanol extract of soft gel capsules of Cervilon and Lumbaton revealed the presence of various bioactive components which include carbohydrate, protein, alkaloids, flavanoids, and saponins. There is no fungal count was observed in plates. Antimicrobial activity was observed in soft gel capsules. They showed significant inhibition in disease causing bacteria. Selected poly herbal capsule have passed through all the WHO parameters which were tested. So it can be concluded that use of capsule was safer and ready to use

Pyrazole-based analogs as potential antibacterial agents against methicillin-resistance staphylococcus aureus (MRSA) and its SAR elucidation

Methicillin-resistant Staphylococcus aureus (MRSA) is becoming lethal to humanity due to easy transmission and difficult-to-treat skin and flimsy diseases. The most threatening aspect is the rapid resistance development of MRSA to any approved antibiotics, including vancomycin. The development of new, efficient, and nontoxic drug candidate to fight against MRSA isolates is the need of the hour. The intriguing molecular structure and versatile bioactive pyrazole core attracting to development required novel antibiotics. This review presents the decade developments of pyrazole-containing derivatives with a broad antibacterial movement against diverged bacterial strains. In specific, we correlated the efficacy of structurally diversified pyrazole analogs against MRSA and discussed different angles of structure-activity relationship (SAR). The current survey highlights pyrazole hybrids' present scenario on MRSA studies, covering articles published from 2011 to 2020. This collective information may become an excellent platform to plan and develop new pyrazole-based small MRSA growth inhibitors with minimal side effects. (C) 2020 Elsevier Masson SAS. All rights reserved

New Strategies for Research in Clinical Practice: A focus on self–harm.

This article suggests new ways of approaching clinical-based research in an era of evidence-based practice. Using the example of self-harm, we identify three distinct problems with current dominant approaches to research in this area. These include insufficient clarity about target issues, an overreliance on predetermined outcomes which prioritise behavioural measures (such as self-harm cessation) and an undue focus on treatment techniques. We argue that clinical research requires flexible, user-centred and practice-based methods, informed by a focus on principles instead of techniques. Therefore, we outline key practice-based principles that we argue need to be embedded within clinical research strategies. We then demonstrate how traditional behavioural approaches to research can be enriched with more qualitative cognitive and emotionally based data. We conclude that such strategies provide thickened, meaningful and context-specific research which is more relevant for service commissioners, clinicians and service users

MACHINE LEARNING ALGORITHMS AND SHAPLEY ADDITIVE EXPLAINABILITY FOR PREDICTING PLAYER PERFORMANCE IN CRICKET

Cricket is a well-liked sport that has enthralled millions of fans worldwide with its fascinating history and action-packed games. An increasing number of people are interested in using data analytics and machine learning to forecast and evaluate cricket player performance. The use of Shapley Additive Explainability to acquire understanding of the elements influencing these predictions is highlighted in this paper’s investigation of the usage of machine learning techniques for player performance prediction in cricket. Machine learning models were developed to predict the performance of batters and bowlers using previous cricket data. These models were selected because they have ensemble learning and gradient boosting features that are suitable for making precise predictions in cricket. Performance metrics were used to assess the models. The findings demonstrated that the models had excellent accuracy and low error values for predicting player performance. Particularly, Light GBM and XGBoost outperformed the Adaboost Regressor model in terms of both batter and bowler predictions. The models’ R2 values demonstrated an excellent fit to the data, capturing a sizeable percentage of the variance in the target variable. The Shapley Additive Explainability framework was used to have a better understanding of the variables affecting the predictions. To assess the significance of each feature in the models, Shapley values were computed. This method revealed the relative importance of traits including opponents’ performance, average venue, average batting average, and strike rate

Metal-insulator transition characteristics of vanadium dioxide thin films synthesized by ultrasonic nebulized spray pyrolysis of an aqueous combustion mixture

We report the synthesis of high quality vanadium dioxide (VO2) thin films by a novel spray pyrolysis technique, namely ultrasonic nebulized spray pyrolysis of aqueous combustion mixture (UNSPACM). This simple and cost effective two step process involves synthesis of a V2O5 film on an LaAlO3 substrate followed by a controlled reduction to form single phase VO2. The formation of M1 phase (p21/c) is confirmed by Raman spectroscopic studies. A thermally activated metal-insulator transition (MIT) was observed at 61 degrees C, where the resistivity changes by four orders of magnitude. Activation energies for the low conduction phase and the high conduction phase were obtained from temperature variable resistance measurements. The infrared spectra also show a dramatic change in reflectance from 13% to over 90% in the wavelength range of 7-15 mu m. This indicates the suitability of the films for optical switching applications at infrared frequencies

BACTERIA ASSOCIATED WITH URINARY TRACT INFECTION IN PREGNANT WOMEN WITH OVERVIEW OF THEIR ANTIBIOTIC SUSCEPTIBILITY TESTS

Urinary tract infection (UTI) is one of the most common health problems among pregnant women and the reason for morbidity during pregnancy in worldwide, most of them in developing countries. The causative agents include Escherichia coli, Klebsiella species, Staphylococcus aureus, Staphylococci, Proteusmirabilis, Enterococcus species, Pseudomonas aeruginosa, Enterobacter species, streptococci, and Citrobacter species. Risk factors in pregnant women is more in urinary tract infection (UTI). This current research aimed that which drug is resistance for pathogenic bacteria and their resistance gene patterns in pregnant women. The altogether predominance of urinary tract infections in pregnant women is approximately 13-18% overall. Gram-positive and gram-negative both bacteria were isolated. Which shows gram-negative bacteria (85%) and gram-positive bacteria were only 15%. E. coliis the most predominant bacteria among the study. And the antimicrobial susceptibility patters of these isolates showed high resistance towards nitrofurantoin, ciprofloxacin, and gentamycin. More sensitive towards amoxiclav, cefuroxime, etc., Pregnant women with Asymptomatic UTI consider E. coli, Klebsiella pneumonia, Proteus mirabilis, Pseudomonas aeruginosa, Acinetobacter baumannii, Staphylococcus arlettae, Enterococcus faecalis and showed resistance to most drugs. The frequent appearance of isolates from urine sample along with their resistance capability tests. The antibiotics can be prescribed based on side effect to prevent pregnant women in case of empirical treatment. In order to overcome the problem of UTI in pregnant women many researches are going on, currently, the drug resistant of UTI is leading to the new technologies and identification method of drug-resistant UTI helps to overcome the infection

Analysis of Stress Concentration of Laminated Composite Plate with Circular Hole

Composite materials are finding a wide range of applications in structural design, especially for lightweight structure that have stringent stiffness and strength requirements. They are attractive replacement for metallic materials for many structural applications. By finding efficient composite str ucture design that meets all requirements of specific application. This is achieved by tailoring of material properties through selective choice of orientation, no. of stacking sequence of layers that make up composite material. Composites are used more and more often for load carrying and safety structures in all kind of applications foe aviation and space technology, for vehicles etc. Composite materials have been introduced progressively in automobiles, followingpolymer materials, a few of which have be en used as matrices. It is interestingto examine the relative masses of different materials which are used in theconstruction of automobiles. Even thoughthe relative mass of polymer - based materials appears low, one needs to take intoaccount that the specif ic mass of steel is about 4 times greater than that of polymers.This explains the higher percentage in terms of volume for the polymers

Effect of Caffeine on Heart Rate and Blood Pressure

Abstract- Caffeine increases systolic blood pressure to extent of 17%and mean arterial blood pressure by about 11%. Heart rate was also increased. The increase in systolic blood pressure was attributed more to the increased stiffness of the aorta and larger blood vessels rather than increased stroke volume. The increase of aortic stiffness is attributed to the increased production of angiotensin II and catecholamines potentially nor adrenaline. These changes are attributable to the inhibition of adenosine A2a receptors activity in the smooth muscles of blood vessels. The concomitant increase in the release of rennin from the kidneys because of the direct stimulation by caffeine and similar activity on sympathetic ganglions releasing noradrenaline contributes to the increased activity of vascular smooth muscles. In the present study, attempt has been made to know the changes occurring in heart rate and blood pressure after the intake of caffeine

PRELIMINARY ORAL PROBIOTICS BACTERIAL PROFILE IN NEONATAL AND PEDIATRICS AND ITS CLINICAL EVALUATION

Probiotics are live bacteria that are consumed or administered to the body to provide health advantages. They are in yoghurt and other fermented food consumer, as well as dietary supplements and cosmetics too. After birth, the mouth of the infant is richly colonized immediately. The different probiotic microorganisms present in infants are Bifidobacterium, Streptococcus salivarius, Streptococcus albicans, Lactobacillus crispatus, Lactobacillus gasseri. Some of these can exhibit some powerful anti-inflammatory capabilities. For the novel application of probiotics in pediatric nutrition, there is a new concept in the composition of the microbiota. In probiotic food, it contains healthy microorganisms, which helps in the safe gut association with lymphoid tissue in infants. Traditionally, probiotics have been associated with gut health, and most clinical interest has been focused on their use for the prevention or treatment of gastrointestinal infections and diseases; however, during the last decade, several investigators have also suggested the use of probiotics for oral health purposes. The aim of this review is to examine the potential mechanisms of probiotic bacteria in the oral cavity and summarize the observed effects of probiotics with respect to oral health. The research focuses on probiotic lactobacilli and its genera that are most used in various probiotic products. Due to this reason, the idea of the usage of probiotics is leading the way to new therapeutic perspectives