A defect-in-continuity in the canine femur: and in-vivo experimental model for the study of bone graft incorporation.

The in-vivo study of bone graft incorporation has traditionally used a segmental diaphyseal bone defect. This model reliably produces a nonunion, but is complicated by graft instability and altered limb loading stresses. The authors discuss the advantages of a defect-in-continuity canine femur model which produces a more consistent union with fewer mechanical complications despite the absence of fixation. This proposed model permits analysis of radiographic, histologic and biomechanical data which are more applicable to the usual clinical setting in which bone graft is required

Einstein Probe - a small mission to monitor and explore the dynamic X-ray Universe

Einstein Probe is a small mission dedicated to time-domain high-energy astrophysics. Its primary goals are to discover high-energy transients and to monitor variable objects in the $0.5-4~$keV X-rays, at higher sensitivity by one order of magnitude than those of the ones currently in orbit. Its wide-field imaging capability, featuring a large instantaneous field-of-view ($60^\circ \times60^\circ$, $\sim1.1$sr), is achieved by using established technology of micro-pore (MPO) lobster-eye optics, thereby offering unprecedentedly high sensitivity and large Grasp. To complement this powerful monitoring ability, it also carries a narrow-field, sensitive follow-up X-ray telescope based on the same MPO technology to perform follow-up observations of newly-discovered transients. Public transient alerts will be downlinked rapidly, so as to trigger multi-wavelength follow-up observations from the world-wide community. Over three of its 97-minute orbits almost the entire night sky will be sampled, with cadences ranging from 5 to 25 times per day. The scientific objectives of the mission are: to discover otherwise quiescent black holes over all astrophysical mass scales by detecting their rare X-ray transient flares, particularly tidal disruption of stars by massive black holes at galactic centers; to detect and precisely locate the electromagnetic sources of gravitational-wave transients; to carry out systematic surveys of X-ray transients and characterize the variability of X-ray sources. Einstein Probe has been selected as a candidate mission of priority (no further selection needed) in the Space Science Programme of the Chinese Academy of Sciences, aiming for launch around 2020.Comment: accepted to publish in PoS, Proceedings of "Swift: 10 Years of Discovery" (Proceedings of Science; ed. by P. Caraveo, P. D'Avanzo, N. Gehrels and G. Tagliaferri). Minor changes in text, references update

The impact of the new CHAMP and GRACE Earth gravity models on the measurement of the general relativistic Lense--Thirring effect with the LAGEOS and LAGEOS II satellites

Among the effects predicted by the General Theory of Relativity for the orbital motion of a test particle, the post-Newtonian gravitomagnetic Lense-Thirring effect is very interesting and, up to now, there is not yet an undisputable experimental direct test of it. To date, the data analysis of the orbits of the existing geodetic LAGEOS and LAGEOS II satellites has yielded a test of the Lense-Thirring effect with a claimed accuracy of 20%-30%. According to some scientists such estimates could be optimistic. Here we wish to discuss the improvements obtainable in this measurement, in terms of reliability of the evaluation of the systematic error and reduction of its magnitude, due to the new CHAMP and GRACE Earth gravity models.Comment: LaTex2e, 6 pages, no figures, no tables. Paper presented at 2nd CHAMP science meeting, Potsdam, 1-4 September 200

A systematic review of randomised controlled trials assessing effectiveness of prosthetic and orthotic interventions.

BACKGROUND: Assistive products are items which allow older people and people with disabilities to be able to live a healthy, productive and dignified life. It has been estimated that approximately 1.5% of the world's population need a prosthesis or orthosis. OBJECTIVE: The objective of this study was to systematically identify and review the evidence from randomized controlled trials assessing effectiveness and cost-effectiveness of prosthetic and orthotic interventions. METHODS: Literature searches, completed in September 2015, were carried out in fourteen databases between years 1995 and 2015. The search results were independently screened by two reviewers. For the purpose of this manuscript, only randomized controlled trials which examined interventions using orthotic or prosthetic devices were selected for data extraction and synthesis. RESULTS: A total of 342 randomised controlled trials were identified (319 English language and 23 non-English language). Only 4 of these randomised controlled trials examined prosthetic interventions and the rest examined orthotic interventions. These orthotic interventions were categorised based on the medical conditions/injuries of the participants. From these studies, this review focused on the medical condition/injuries with the highest number of randomised controlled trials (osteoarthritis, fracture, stroke, carpal tunnel syndrome, plantar fasciitis, anterior cruciate ligament, diabetic foot, rheumatoid and juvenile idiopathic arthritis, ankle sprain, cerebral palsy, lateral epicondylitis and low back pain). The included articles were assessed for risk of bias using the Cochrane Risk of Bias tool. Details of the clinical population examined, the type of orthotic/prosthetic intervention, the comparator/s and the outcome measures were extracted. Effect sizes and odds ratios were calculated for all outcome measures, where possible. CONCLUSIONS: At present, for prosthetic and orthotic interventions, the scientific literature does not provide sufficient high quality research to allow strong conclusions on their effectiveness and cost-effectiveness

Factors Associated with Revision Surgery after Internal Fixation of Hip Fractures

Background: Femoral neck fractures are associated with high rates of revision surgery after management with internal fixation. Using data from the Fixation using Alternative Implants for the Treatment of Hip fractures (FAITH) trial evaluating methods of internal fixation in patients with femoral neck fractures, we investigated associations between baseline and surgical factors and the need for revision surgery to promote healing, relieve pain, treat infection or improve function over 24 months postsurgery. Additionally, we investigated factors associated with (1) hardware removal and (2) implant exchange from cancellous screws (CS) or sliding hip screw (SHS) to total hip arthroplasty, hemiarthroplasty, or another internal fixation device. Methods: We identified 15 potential factors a priori that may be associated with revision surgery, 7 with hardware removal, and 14 with implant exchange. We used multivariable Cox proportional hazards analyses in our investigation. Results: Factors associated with increased risk of revision surgery included: female sex, [hazard ratio (HR) 1.79, 95% confidence interval (CI) 1.25-2.50; P = 0.001], higher body mass index (fo