Discontinuities in the late 1960's in different atmospheric data products

An analysis of the onset and spatial extent of discontinuities in the late 1960's in different atmospheric data products is performed. Discontinuities are found in both the NCEP/NCAR and ERA-40 reanalyses in various surface variables including sea level pressure (SLP) in both data sets over Africa, in the NCEP/NCAR reanalysis also over Asia and in the ERA-40 reanalysis also over South America, and precipitation in the NCEP/NCAR reanalysis over North Africa. Discontinuities are also found in 2 m air temperature in both reanalyses. The discontinuities in SLP extend into the lower troposphere. The main cause of these discontinuities appears to be missing or limited synoptic data prior to the late 1960's

Spontaneous bleeding in a patient with malignant lymphoma: A case of acquired hemophilia

Background: Acquired hemophilia is a rare condition which can be associated with lymphoproliferative disease. Case Report: Eleven yea rs after the diagnosis of immunocytoma had been made, a 72-year-old man developed a high-titer factor VIII inhibitor. At this time, the lymphoma was without significant progress and there was no paraprotein in the serum. Partial thromboplastin time (PTT) was 83 a, factor-VIII clotting activity was <1%, and inhibitor level was 50.4 Bethesda units. The patient presented with spontaneous hematomas in the skin and musculature of the extremities. Following combination chemotherapy with cyclophosphamide, vincristine and prednisolone (COP), there was a prompt disappearance of the inhibitor and normalization of coagulation; however, the patient developed serious infectious complications. When the inhibitor recurred he was treated with low-dose cyclophosphamide and prednisolone. This time there was a more delayed response, but the inhibitor disappeared again completely. Two months after cessation of therapy, there was again relapse. Conclusion: Causal relationship between lymphoma and acquired hemophilia remains speculative. At least in some cases of factor VIII inhibitors associated with malignant disease, immunosuppressive therapy may be sufficient to suppress the inhibitor

Advanced head and neck cancer: Long-term results of chemo-radiotherapy, complications and induction of second malignancies

Background: Chemo-radiotherapy is superior to radiotherapy alone in the treatment of advanced, inoperable head and neck cancer. The long-term treatment results, the induction of second malignant tumors, and other long-term toxicities are not well defined. Patients and Methods: 100 consecutive patients with advanced head and neck cancer who were treated at our center were studied. Treatment results, survival, the occurrence of late complications, and second malignant tumors (SMT) were investigated. 78 patients were treated with a protocol combining cisplatinum, 5-fluorouracil, folinic acid and hyper-fractionated irradiation. 22 patients were treated with other chemo-radiotherapy protocols. The relative risk of developing an SMT was compared with that within the normal population. Results: The cumulative total probability of survival was 51.1% at 2 years and 38.7% at 4 years. The probability of relapse-free survival was 39.9% at 2 years and 36.7% at 4 years. A total of 7 patients developed SMT (4 cases of lung cancer, 2 colon cancers, 1 skin cancer). After 6 years, a cumulative risk of SMT of 8.7% was observed. The relative risk of developing an SMT was significantly increased (4.45-fold in males) compared with a normal population. 13 of 38 evaluable patients (34.2%) had severe late complications like fibrosis of soft tissues, nerve lesions, or were dependent on tracheal cannulas. Conclusions: The treatment results and long-term prognoses in our population of unselected high-risk patients are unsatisfactory, but comparable to those from multicenter studies. About 35% of patients become long-term (> 4 years) survivors. SMT generally occur early, have a poor prognosis and, most likely, are not treatment-related. Approximately 30% of long-term survivors have severe, often incapacitating late effects. The treatment and - if possible - prevention of these late effects is important for the quality of life of patients who survived advanced head and neck cancer

Three-dimensional mapping of equiprobable hydrostratigraphic units at the Frenchman Flat Corrective Action Unit, Nevada Test Site

Geological and geophysical data are used with the sequential indicator simulation algorithm of Gomez-Hernandez and Srivastava to produce multiple, equiprobable, three-dimensional maps of informal hydrostratigraphic units at the Frenchman Flat Corrective Action Unit, Nevada Test Site. The upper 50 percent of the Tertiary volcanic lithostratigraphic column comprises the study volume. Semivariograms are modeled from indicator-transformed geophysical tool signals. Each equiprobable study volume is subdivided into discrete classes using the ISIM3D implementation of the sequential indicator simulation algorithm. Hydraulic conductivity is assigned within each class using the sequential Gaussian simulation method of Deutsch and Journel. The resulting maps show the contiguity of high and low hydraulic conductivity regions

Near-field modeling in Frenchman Flat, Nevada Test Site

The US Department of Energy (DOE) is investigating the effects of nuclear testing in underground test areas (the UGTA program) at the Nevada Test Site. The principal focus of the UGTA program is to better understand and define subsurface radionuclide migration. The study described in this report focuses on the development of tools for generating maps of hydrogeologic characteristics of subsurface Tertiary volcanic units at the Frenchman Flat corrective Action Unit (CAU). The process includes three steps. The first step involves generation of three-dimensional maps of the geologic structure of subsurface volcanic units using geophysical logs to distinguish between two classes: densely welded tuff and nonwelded tuff. The second step generates three-dimensional maps of hydraulic conductivity utilizing the spatial distribution of the two geologic classes obtained in the first step. Each class is described by a correlation structure based on existing data on hydraulic conductivity, and conditioned on the generated spatial location of each class. The final step demonstrates the use of the maps of hydraulic conductivity for modeling groundwater flow and radionuclide transport in volcanic tuffs from an underground nuclear test at the Frenchman Flat CAU. The results indicate that the majority of groundwater flow through the volcanic section occurs through zones of densely welded tuff where connected fractures provide the transport pathway. Migration rates range between near zero to approximately four m/yr, with a mean rate of 0.68 m/yr. This report presents the results of work under the FY96 Near-Field Modeling task of the UGTA program

Physicochemical characterization of a hydrophilic model drug-loaded PHBV microparticles obtained by the double emulsion/solvent evaporation technique

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Trajectory Model for Identification of Oil Spill Around the Coast of Pari Island, Seribu Islands, North Jakarta

Oil spills at sea are common in the shipping lanes of the ship as well as the locations of offshore oil drilling. Unfortunately, in every occurrence of the oil spill, we only see the effects after the occurrence, without knowing the original source. Indonesian Numerical Coastal Environmental Assessment (IndoNACE) is research collaboration between Indonesian and Germany by applying satellite data, numerical modeling, and field observations to make an assessment on environmental consequences to oil spills at sea. One of the locations of these research activities is Pari Island, Seribu Islands, North Jakarta. Simulation of hydrodynamic models around Pulau Pari with Hamburg Shelf Ocean Model (HAMSOM) was performed using tides, surface winds, and density difference of seawater as input. Afterwards, by utilizing results of the hydrodynamic model, the spreading of oil spills as well as the origin of the oil spills were estimated using forward and backward trajectory models, respectively. In the case study of Pari Island, there is a presence of thin film of oil in 5 November 2015 that disappears after one day. We suggest that the origin of oil spills were found on the beach Pari Island is expected from the east - northeast of Thousand Islands and is likely from the subsea pipeline which runs from the north to the city of Jakarta or shipping lanes through the Indonesian archipelagic sea lanes (ALKI) I of Karimata Strait up to Java Sea and the Jakarta Bay