Adriana R. Pohlmann

Paulo V. Farago

Renata P. Raffin

Sílvia S. Guterres

Sônia F. Zawadzki

Journal of the Brazilian Chemical Society

English

A Renata P. Raffin

B Adriana R. Pohlmann

Sílvia S. Guterresb

CiteSeerX

Physicochemical characterization of a hydrophilic model drug-loaded PHBVmicroparticles obtained by the double emulsion/solvent evaporation technique

Micropartículas de poli(3-hidroxibutirato-co-3-hidroxivalerato) (PHBV) contendo um fármaco modelo hidrofílico, o cloridrato de metformina (MH), foram obtidas pela técnica de emulsão múltipla/evaporação do solvente. Diversas formulações foram preparadas, com o objetivo de investigar a influência de cada composição sobre a eficiência de encapsulação (EE). O resultado mais elevado de EE (9,76%) foi verificado quando da simultânea alcalinização e adição de NaCl na fase aquosa externa da formulação. O estudo por MEV das micropartículas revelou morfologia esférica e superfície rugosa. As intensidades de difração cristalina para as micropartículas contendo o MH foram menores do que aquelas observadas para a mistura física. Os resultados obtidos por IVTF sugerem que nenhuma ligação química foi formada entre o polímero e o fármaco. A avaliação por análise térmica indica o surgimento de interações favoráveis entre MH e PHBV. O estudo de liberação in vitro demonstrou a influência do PHBV no perfil de dissolução do MH.Poly(3-hydroxybutirate-co-3-hydroxyvalerate) (PHBV) microparticles containing a water-soluble model drug, metformin hydrochloride (MH), were obtained by a double emulsion/solvent evaporation technique. Several formulations were prepared in order to investigate the influence of each composition on the encapsulation efficiency (EE). The highest value of EE (9.76%) was obtained using simultaneously pH alkalinization and NaCl addition in the external water phase of the formulation. SEM study revealed a spherical morphology and a rough surface. The crystalline diffraction intensities for the MH-loaded microparticles were lower than that verified for the physical mixture. FTIR results suggested that no chemical bond between the polymer and the drug was formed. Also thermal analyses indicated a favorable interaction between MH and PHBV. In vitro drug release demonstrated the influence of the PHBV on the dissolution profile of MH

Farago, Paulo Vitor

Raffin, Renata Platcheck

Pohlmann, Adriana Raffin

Sílvia Stanisçuaski Guterres

Zawadzki, Sônia Faria

Lume 5.8

Physicochemical characterization of a hydrophilic model drug-loaded PHBV microparticles obtained by the double emulsion/solvent evaporation technique

Crossref

https://lume.ufrgs.br/bitstream/10183/24587/1/000660198.pdf

Physicochemical characterization of a hydrophilic model drug-loaded PHBV microparticles obtained by the double emulsion/solvent evaporation technique

Abstract

Similar works

Full text

Available Versions

CiteSeerX

Lume 5.8

Crossref