6,042 research outputs found
A method to impregnate wet soil samples, producing high-quality thin sections.
[120.031]Mineral soils with different moisture content and texture were impregnated successfully by the method described. The water present in the soil sample is replaced by acetone and the acetone-saturated sample is impregnated by FitzPatrick's method (1970) (using acetone as thinner of the polyester resin Synolith 544). Shrinkage is minimal and the thin sections are of high quality. It should be possible to correlate thin section data obtained by this method with physical data obtained from undisturbed material. Micromorphologically, a better understanding of the plasmic fabrics should be possible. (Abstract retrieved from CAB Abstracts by CABI’s permission
In Vitro Antitumor Effects of the Cold-Water Extracts of Mediterranean Species of Genus Pleurotus (Higher Basidiomycetes) on Human Colon Cancer Cells
The aim of the present study was to evaluate whether the cold-water extract of Pleurotus eryngii var. ferulae (CWE-Pef) and Pleurotus nebrodensis (CWE-Pn), two of the most prized wild and cultivated edible mushrooms can affect the tumour phenotype of human colon cancer HCT116 cells. Our results showed that treatment with CWE-Pef and CWE-Pn resulted in a significant inhibition of the viability of HCT116 cells and promoted apoptosis as also demonstrated by the increase of bax/bcl-2 mRNA ratio. Moreover, we observed that both extracts were able to inhibit cell migration and to affect homotypic and heterotypic cell-cell adhesion. It was also found that treatment with CWE-Pef and CWE-Pn negatively modulated the protein tyrosine phosphorylation as well as the phosphorylation levels of ERK1/2.
In conclusion, the in vitro antitumor effects of CWE-Pef and CWE-Pn indicate that they can be considered as possible sources for new alternative therapeutic agents for cancer treatment
Role of S128R polymorphism of E-selectin in colon metastasis formation
The extravasation of cancer cells is a key step of the metastatic cascade. Polymorphisms in genes encoding adhesion molecules can facilitate metastasis by increasing the strength of interaction between tumor and endothelial cells as well as impacting other properties of cancer cells. We investigated the Ser128Arg (a561c at the nucleotide level) polymorphism in the E-selectin gene in patients with metastatic colon cancer and its functional significance. Genotyping for a561c polymorphism was performed on 172 cancer patients and on an age-matched control population. The colon cancer group was divided into groups with (M(+)) and without observable metastasis (M(-)). For in vitro functional assays, Huvec transfected cells expressing wild-type (WT) or the S128R variant of E-selectin were established to study in vitro binding ability and signal transduction processes of T84 colon cancer cell line. Our results demonstrated that the Arginine(128) allele was more prevalent in the M(+) group than in the M(-) group or normal controls (p < 0.005; odds ratio, 1.56; 95% confidence interval (CI) 1.16-1.92; p < 0.001, odds ratio = 1.65; CI = 1.24-1.99, respectively). In vitro, S128R E-selectin transfected Huvec cells, supported increased adhesion as well as increased cellular signaling of T84 cancer cells compared to WT E-selectin and mock-transfected Huvec cells. These findings suggest that the E-selectin S128R polymorphism can functionally affect tumor-endothelial interactions as well as motility and signaling properties of neoplastic cells that may modulate the metastatic phenotype
Spectroscopy of Na: Bridging the two-proton radioactivity of Mg
The unbound nucleus Na, the intermediate nucleus in the two-proton
radioactivity of Mg, was studied by the measurement of the resonant
elastic scattering reaction Ne(p,Ne)p performed at 4 A.MeV.
Spectroscopic properties of the low-lying states were obtained in a R-matrix
analysis of the excitation function. Using these new results, we show that the
lifetime of the Mg radioactivity can be understood assuming a sequential
emission of two protons via low energy tails of Na resonances
Spectral quantification of nonlinear behaviour of the nearshore seabed and correlations with potential forcings at Duck, N.C., U.S.A
Local bathymetric quasi-periodic patterns of oscillation are identified from
monthly profile surveys taken at two shore-perpendicular transects at the USACE
field research facility in Duck, North Carolina, USA, spanning 24.5 years and
covering the swash and surf zones. The chosen transects are the two furthest
(north and south) from the pier located at the study site. Research at Duck has
traditionally focused on one or more of these transects as the effects of the
pier are least at these locations. The patterns are identified using singular
spectrum analysis (SSA). Possible correlations with potential forcing
mechanisms are discussed by 1) doing an SSA with same parameter settings to
independently identify the quasi-periodic cycles embedded within three
potentially linked sequences: monthly wave heights (MWH), monthly mean water
levels (MWL) and the large scale atmospheric index known as the North Atlantic
Oscillation (NAO) and 2) comparing the patterns within MWH, MWL and NAO to the
local bathymetric patterns. The results agree well with previous patterns
identified using wavelets and confirm the highly nonstationary behaviour of
beach levels at Duck; the discussion of potential correlations with
hydrodynamic and atmospheric phenomena is a new contribution. The study is then
extended to all measured bathymetric profiles, covering an area of 1100m
(alongshore) by 440m (cross-shore), to 1) analyse linear correlations between
the bathymetry and the potential forcings using multivariate empirical
orthogonal functions (MEOF) and linear correlation analysis and 2) identify
which collective quasi-periodic bathymetric patterns are correlated with those
within MWH, MWL or NAO, based on a (nonlinear) multichannel singular spectrum
analysis (MSSA). (...continued in submitted paper)Comment: 50 pages, 3 tables, 8 figure
Dark Matter in the MSSM
We have recently examined a large number of points in the parameter space of
the phenomenological MSSM, the 19-dimensional parameter space of the
CP-conserving MSSM with Minimal Flavor Violation. We determined whether each of
these points satisfied existing experimental and theoretical constraints. This
analysis provides insight into general features of the MSSM without reference
to a particular SUSY breaking scenario or any other assumptions at the GUT
scale. This study opens up new possibilities for SUSY phenomenology both in
colliders and in astrophysical experiments. Here we shall discuss the
implications of this analysis relevant to the study of dark matter.Comment: 27 pages, 19 figs; Journal version in NJP issue "Focus on Dark Matter
and Particle Physics". Previous version had 26 pages, 19 figures. Text and
some figures have been update
TNM Staging of Neoplasms of the Endocrine Pancreas: Results From a Large International Cohort Study
Background Both the European Neuroendocrine Tumor Society (ENETS) and the International Union for Cancer Control/American Joint Cancer Committee/World Health Organization (UICC/AJCC/WHO) have proposed TNM staging systems for pancreatic neuroendocrine neoplasms. This study aims to identify the most accurate and useful TNM system for pancreatic neuroendocrine neoplasms. Methods The study included 1072 patients who had undergone previous surgery for their cancer and for which at least 2 years of follow-up from 1990 to 2007 was available. Data on 28 variables were collected, and the performance of the two TNM staging systems was compared by Cox regression analysis and multivariable analyses. All statistical tests were two-sided. Results Differences in distribution of sex and age were observed for the ENETS TNM staging system. At Cox regression analysis, only the ENETS TNM staging system perfectly allocated patients into four statistically significantly different and equally populated risk groups (with stage I as the reference; stage II hazard ratio [HR] of death = 16.23, 95% confidence interval [CI] = 2.14 to 123, P = .007; stage III HR of death = 51.81, 95% CI = 7.11 to 377, P < .001; and stage IV HR of death = 160, 95% CI = 22.30 to 1143, P < .001). However, the UICC/AJCC/WHO 2010 TNM staging system compressed the disease into three differently populated classes, with most patients in stage I, and with the patients being equally distributed into stages II-III (statistically similar) and IV (with stage I as the reference; stage II HR of death = 9.57, 95% CI = 4.62 to 19.88, P < .001; stage III HR of death = 9.32, 95% CI = 3.69 to 23.53, P = .94; and stage IV HR of death = 30.84, 95% CI = 15.62 to 60.87, P < .001). Multivariable modeling indicated curative surgery, TNM staging, and grading were effective predictors of death, and grading was the second most effective independent predictor of survival in the absence of staging information. Though both TNM staging systems were independent predictors of survival, the UICC/AJCC/WHO 2010 TNM stages showed very large 95% confidence intervals for each stage, indicating an inaccurate predictive ability. Conclusion Our data suggest the ENETS TNM staging system is superior to the UICC/AJCC/WHO 2010 TNM staging system and supports its use in clinical practic
Supersymmetric Benchmarks with Non-Universal Scalar Masses or Gravitino Dark Matter
We propose and examine a new set of benchmark supersymmetric scenarios, some
of which have non-universal Higgs scalar masses (NUHM) and others have
gravitino dark matter (GDM). The scalar masses in these models are either
considerably larger or smaller than the narrow range allowed for the same
gaugino mass m_{1/2} in the constrained MSSM (CMSSM) with universal scalar
masses m_0 and neutralino dark matter. The NUHM and GDM models with larger m_0
may have large branching ratios for Higgs and/or production in the cascade
decays of heavier sparticles, whose detection we discuss. The phenomenology of
the GDM models depends on the nature of the next-to-lightest supersymmetric
particle (NLSP), which has a lifetime exceeding 10^4 seconds in the proposed
benchmark scenarios. In one GDM scenario the NLSP is the lightest neutralino
\chi, and the supersymmetric collider signatures are similar to those in
previous CMSSM benchmarks, but with a distinctive spectrum. In the other GDM
scenarios based on minimal supergravity (mSUGRA), the NLSP is the lighter stau
slepton {\tilde \tau}_1, with a lifetime between ~ 10^4 and 3 X 10^6 seconds.
Every supersymmetric cascade would end in a {\tilde \tau}_1, which would have a
distinctive time-of-flight signature. Slow-moving {\tilde \tau}_1's might be
trapped in a collider detector or outside it, and the preferred detection
strategy would depend on the {\tilde \tau}_1 lifetime. We discuss the extent to
which these mSUGRA GDM scenarios could be distinguished from gauge-mediated
models.Comment: 52 pages LaTeX, 13 figure
Supersymmetry Without Prejudice
We begin an exploration of the physics associated with the general
CP-conserving MSSM with Minimal Flavor Violation, the pMSSM. The 19 soft SUSY
breaking parameters in this scenario are chosen so as to satisfy all existing
experimental and theoretical constraints assuming that the WIMP is a
conventional thermal relic, ie, the lightest neutralino. We scan this parameter
space twice using both flat and log priors for the soft SUSY breaking mass
parameters and compare the results which yield similar conclusions. Detailed
constraints from both LEP and the Tevatron searches play a particularly
important role in obtaining our final model samples. We find that the pMSSM
leads to a much broader set of predictions for the properties of the SUSY
partners as well as for a number of experimental observables than those found
in any of the conventional SUSY breaking scenarios such as mSUGRA. This set of
models can easily lead to atypical expectations for SUSY signals at the LHC.Comment: 61 pages, 24 figs. Refs., figs, and text added, typos fixed; This
version has reduced/bitmapped figs. For a version with better figs please go
to http://www.slac.stanford.edu/~rizz
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