Evolution Of Special Ruled Surfaces Via The Evolution Of Their Directrices In Euclidean 3-Space E3

In this paper, evolutions of ruled surfaces that are generated by the normal and binormal vector fields of space curve (normal and binormal surfaces) are presented. These evolutions of the ruled surfaces depend on the evolutions of their directrices. Geometric visualization of these ruled surfaces are presented. In addition, the conditions which make these surfaces of types inextensible, developable and minimal are obtained

THE PROTECTIVE ROLE OF OMEGA-3 AGAINST GENOTOXICITY AND REPRODUCTIVE TOXICITY OF COBALT OXIDE NANOPARTICLES ACUTE TREATMENT IN MALE MICE

Objective: Cobalt nanoparticles (NPs), especially cobalt oxide NPs (Co3O4 NPs) are attracting unique shaped NPs that are used in different biomedical applications and medicine. Different in vitro studies report their toxic and carcinogenic effect but limited in vivo studies were present on its genotoxic potential. The present study was aimed to evaluate the genotoxic potential of Co3O4 NPs on bone marrow cells and sperms and the protective role of omega-3 in male albino mice.Methods: Animals were segregated into four groups that were orally treated for 3 consecutive days, Group 1: Negative control; Group 2: Omega-3 (250 mg/kg); Group 3: Co3O4 NPs (20 mg/kg); and Group 4: Combined group (250 mg/kg Omega-3 and Co3O4 NPs 20 mg/kg).Results: The present results show that Co3O4 NPs administration significantly increased number of micronucleated polychromatic erythrocytes (PCEs)/1000 PCEs, sperm abnormalities, and DNA damage, significantly decreased sperm motility and concentration in comparison to negative control group. However, Omega-3 administration in the combined group modulates the genotoxic potential of Co3O4 NPs in comparison to Co3O4 NPs group.Conclusion: The present study reports the genotoxic potential of Co3O4 NPs in vivo and assesses the protective role of Omega-3 administration due to its antioxidant effect

Heavy Naphtha Desulfurization by Ozone Generated via the DBD Plasma Reactor

   This work presents an investigation into the ultra-desulfurization of heavy naphtha fuel (model using BT and DBT) using oxidation and solvent extraction techniques. Ozone produced by the DBD (Dielectric barrier discharge) plasma generator was employed in the oxidation process as an oxidant, and acetonitrile was used as a solvent extraction. Box-Behnken experimental design was adopted in the current study to examine oxidation desulfurization by non-thermal plasma for the various operation conditions including time, flow rate, and temperature on sulfur removal efficiency. Acetonitrile with an oxidized oil/solvent ratio of 1:1(v/v ratio) was utilized as the extraction solvent.  The results showed that the maximum sulfur removal of about 91% was obtained with a temperature of 50°C, flow rate of 75 ml/min, and time of 4 hours

Study of the ground state energies of some nuclei using hybrid model

The present work deals with study of the effect using both quark and meson degrees of freedom in case of the ground state calculations for some light nuclei. The nuclear properties can be described microscopically ranged from the empirical picture to t the experimental data. We study the nucleon-nucleon interaction via the one-boson exchange potential; OBEP ; with two, three and four mesons. The Dirac-Hartree-Fock equation is used to determine the Hamiltonian equation for the meson degrees of freedom. The effect of quark degrees of freedom is considered according to the variational concept besides the meson degrees of freedom and observe the differences in the ground state energies for some nuclei. The calculation of quark-quark interaction includes the effect of instanton induced interaction through the Cornell dressed potential, and the nucleon-nucleon interaction with the exchange of mesons via OBEP . Two meson functions are used, the generalized Yukawa; GY ; and single particle energy dependent; SBED; functions to demonstrate the differences of each one in our calculations. The effect of including more degrees of freedom in calculating the nuclear properties has a satisfied result in case of four mesons exchange using OPEP with and without the quark-quark interaction and gives an encouraged search to continue with it

Non-pharmacological Treatment of Ascites

Diuretics are considered the first-line pharmacological treatment option for ascites. Diuretic treatment begins with spironolactone and furosemide. Non-pharmacological options include salt restriction, large-volume paracentesis (LVP), transjugular intrahepatic portosystemic shunt (TIPS), and peritoneovenous shunt. Ascites can be mobilized if renal sodium excretion tops 78 mmol daily (88 mmol–10 mmol daily) after restricting sodium intake to 88 mmol/day (about 2000 mg/day). The majority of patients with cirrhotic ascites respond to a combination of sodium restriction and diuretics such as spironolactone and furosemide (90%). Ascites that does not respond to sodium restriction and high-dose diuretic treatment (400 mg/day of spironolactone and 160 mg/day of furosemide) or following paracentesis is labeled refractory. Refractory ascites can be managed with large-volume paracentesis or transjugular intrahepatic portosystemic shunt. Peritoneovenous shunting is considered as a third-line treatment option after all other measures such as diuretics, large-volume paracentesis, or transjugular intrahepatic portosystemic shunt deemed unsuccessful or contraindicated. It has a high rate of shunt obstruction

Development of hand-arm model rig for tremor excitation

This paper describes the development of a handarm model rig to simulate human tremor behaviour. The experimental rig is designed as an apparatus to induce vibration along a hand-arm model. An Intra Vernacular (IV) Training arm is used as the handarm model. Displacement and acceleration behaviour at three selected points along the handarm model were recorded by mean of piezoelectric accelerometer. The data from the experiment can be used for further analysis of the human hand-arm tremor especially for Parkinson's disease (PD) patients. Results from the experiments are raw data which can later be used in designing an appropriate instrument that can suppress the hand tremor

An investigation of domestic water consumption in Sirte, Libya

This is the final version. Available from Taylor & Francis via the DOI in this record. The paper investigates per capita water consumption in Sirte city using a questionnaire survey data. The data captured included frequency, duration, flow rate, time of water use for each water end-use and household characteristics (demographic and socio-economic). The results show that the average daily per capita water consumption is 255 l/p/d. The per capita water consumption decreases with the increase in family size, while household income does not affect water consumption. Handwash basin tap accounts for the highest water consumption. The diurnal water consumption pattern is different from developed countries patterns and has multiple peaks. To predict the city’s future water demand, three statistical models based on multiple linear regression technique (STEPWISE) were developed. The comparison of the developed models suggests that the models based on demographic variables can produce acceptable results and any further inclusion of additional variables (physical characteristics of households) do not necessarily improve the prediction accuracy. .Ministry of Higher Education and Scientific Research in Liby

Impurity effects on the melting of Ni clusters

We demonstrate that the addition of a single carbon impurity leads to significant changes in the thermodynamic properties of Ni clusters consisting of more than a hundred atoms. The magnitude of the change induced is dependent upon the parameters of the Ni-C interaction. Hence, thermodynamic properties of Ni clusters can be effectively tuned by the addition of an impurity of a particular type. We also show that the presence of a carbon impurity considerably changes the mobility and diffusion of atoms in the Ni cluster at temperatures close to its melting point. The calculated diffusion coefficients of the carbon impurity in the Ni cluster can be used for a reliable estimate of the growth rate of carbon nanotubes.Comment: 27 pages, 13 figure

Bi-allelic GAD1 variants cause a neonatal onset syndromic developmental and epileptic encephalopathy.

Developmental and epileptic encephalopathies are a heterogeneous group of early-onset epilepsy syndromes dramatically impairing neurodevelopment. Modern genomic technologies have revealed a number of monogenic origins and opened the door to therapeutic hopes. Here we describe a new syndromic developmental and epileptic encephalopathy caused by bi-allelic loss-of-function variants in GAD1, as presented by 11 patients from six independent consanguineous families. Seizure onset occurred in the first 2 months of life in all patients. All 10 patients, from whom early disease history was available, presented with seizure onset in the first month of life, mainly consisting of epileptic spasms or myoclonic seizures. Early EEG showed suppression-burst or pattern of burst attenuation or hypsarrhythmia if only recorded in the post-neonatal period. Eight patients had joint contractures and/or pes equinovarus. Seven patients presented a cleft palate and two also had an omphalocele, reproducing the phenotype of the knockout Gad1-/- mouse model. Four patients died before 4 years of age. GAD1 encodes the glutamate decarboxylase enzyme GAD67, a critical actor of the γ-aminobutyric acid (GABA) metabolism as it catalyses the decarboxylation of glutamic acid to form GABA. Our findings evoke a novel syndrome related to GAD67 deficiency, characterized by the unique association of developmental and epileptic encephalopathies, cleft palate, joint contractures and/or omphalocele