Avaliação preliminar de variedades de polinização aberta de milho em Santa Catarina nas safras 2009/10 e 2010/11.

Introdução; Material e Métodos; Resultados e Discussão; Conclusão; Referências bibliográficas; Tabelas

Altering Chemosensitivity by Modulating Translation Elongation

BACKGROUND: The process of translation occurs at a nexus point downstream of a number of signal pathways and developmental processes. Modeling activation of the PTEN/AKT/mTOR pathway in the Emu-Myc mouse is a valuable tool to study tumor genotype/chemosensitivity relationships in vivo. In this model, blocking translation initiation with silvestrol, an inhibitor of the ribosome recruitment step has been showed to modulate the sensitivity of the tumors to the effect of standard chemotherapy. However, inhibitors of translation elongation have been tested as potential anti-cancer therapeutic agents in vitro, but have not been extensively tested in genetically well-defined mouse tumor models or for potential synergy with standard of care agents. METHODOLOGY/PRINCIPAL FINDINGS: Here, we chose four structurally different chemical inhibitors of translation elongation: homoharringtonine, bruceantin, didemnin B and cycloheximide, and tested their ability to alter the chemoresistance of Emu-myc lymphomas harbouring lesions in Pten, Tsc2, Bcl-2, or eIF4E. We show that in some genetic settings, translation elongation inhibitors are able to synergize with doxorubicin by reinstating an apoptotic program in tumor cells. We attribute this effect to a reduction in levels of pro-oncogenic or pro-survival proteins having short half-lives, like Mcl-1, cyclin D1 or c-Myc. Using lymphomas cells grown ex vivo we reproduced the synergy observed in mice between chemotherapy and elongation inhibition and show that this is reversed by blocking protein degradation with a proteasome inhibitor. CONCLUSION/SIGNIFICANCE: Our results indicate that depleting short-lived pro-survival factors by inhibiting their synthesis could achieve a therapeutic response in tumors harboring PTEN/AKT/mTOR pathway mutations

Reduced costs with bisoprolol treatment for heart failure - An economic analysis of the second Cardiac Insufficiency Bisoprolol Study (CIBIS-II)

Background Beta-blockers, used as an adjunctive to diuretics, digoxin and angiotensin converting enzyme inhibitors, improve survival in chronic heart failure. We report a prospectively planned economic analysis of the cost of adjunctive beta-blocker therapy in the second Cardiac Insufficiency BIsoprolol Study (CIBIS II). Methods Resource utilization data (drug therapy, number of hospital admissions, length of hospital stay, ward type) were collected prospectively in all patients in CIBIS . These data were used to determine the additional direct costs incurred, and savings made, with bisoprolol therapy. As well as the cost of the drug, additional costs related to bisoprolol therapy were added to cover the supervision of treatment initiation and titration (four outpatient clinic/office visits). Per them (hospital bed day) costings were carried out for France, Germany and the U.K. Diagnosis related group costings were performed for France and the U.K. Our analyses took the perspective of a third party payer in France and Germany and the National Health Service in the U.K. Results Overall, fewer patients were hospitalized in the bisoprolol group, there were fewer hospital admissions perpatient hospitalized, fewer hospital admissions overall, fewer days spent in hospital and fewer days spent in the most expensive type of ward. As a consequence the cost of care in the bisoprolol group was 5-10% less in all three countries, in the per them analysis, even taking into account the cost of bisoprolol and the extra initiation/up-titration visits. The cost per patient treated in the placebo and bisoprolol groups was FF35 009 vs FF31 762 in France, DM11 563 vs DM10 784 in Germany and pound 4987 vs pound 4722 in the U.K. The diagnosis related group analysis gave similar results. Interpretation Not only did bisoprolol increase survival and reduce hospital admissions in CIBIS II, it also cut the cost of care in so doing. This `win-win' situation of positive health benefits associated with cost savings is Favourable from the point of view of both the patient and health care systems. These findings add further support for the use of beta-blockers in chronic heart failure

Compendium voor de verplichte tegenprestatie bijstandsgerechtigden

Sinds 1 januari 2015 maakt de tegenprestatie onderdeel uit van de Participatiewet. Het hoofddoel van deze nieuwe wet is dat meer mensen betaald werk vinden, ook mensen met een arbeidsbeperking. De tegenprestatie mag niet verward worden met verplichte onbetaalde arbeid in het kader van de re-integratie. De re-integratietrajecten zijn bedoeld om de bijstandsgerechtigden te ondersteunen bij de terugkeer naar werk. De tegenprestatie is bedoeld om de bijstandsgerechtigde iets terug te laten doen voor de ontvangen uitkering. Tijdens onderzoek naar de gang van zaken bij de verplichte tegenprestatie voor bijstandsgerechtigden in Rotterdam werd duidelijk, dat een handleiding vanuit het perspectief van de klant ontbreekt terwijl daar wel behoefte aan bestaat. Om in die behoefte te voorzien hebben wij een compendium ontwikkeld. Het compendium gaat in op de rechten, plichten en risico’s voor de bijstandsgerechtigde die met de tegenprestatie te maken krijgt. Ook licht het compendium het perspectief van de uitvoerders toe en biedt het een overzicht van de argumenten van voor- en tegenstanders van de tegenprestatie. Het compendium sluit af met 25 tips gericht op wat u als bijstandsgerechtigde kunt doen om het contact met uw gemeente over de tegenprestatie goed te laten verlopen

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Internal structure of a thin film of mixed polymeric micelles on a solid/liquid interface

The adsorption of mixed micelles of poly(4-(2-amino hydrochloride-ethylthio)-butylene)-block-poly(ethylene oxide), PAETB49-b-PEO212 and poly(4-(2-sodium carboxylate-ethylthio)-butylene)-block-poly(ethylene oxide), PCETB47-b-PEO212 on solid/liquid interfaces has been studied with light, X-ray, and neutron reflectometry. The structure of the adsorbed layer can be described with a two-layer model consisting of an inner layer formed by the coacervate of the polyelectrolyte blocks PAETB49 and PCETB47 (~1 nm) and an outer layer of PEO212 blocks (~6 nm). The micelles unfold upon adsorption forming a rather homogeneous flat layer that exposes its polyethylene oxide chains into the solution, thus rendering the surface antifouling after modification with the micelles

Potential impact of floating solar panels on water quality in reservoirs; pathogens and leaching

Application of floating solar panels is especially suited for the Netherlands, given the limited availability of land (surface area). Evides water company owns and operates several open storage reservoirs which can be used for installation of these panels, but the installations could affect the local environment, naturally occurring processes and water quality. In this research, we evaluate leaching of various substances and possible effects based on a theoretical approach following the Analysis of Microbiological Safety of Drinking water (AMSD method). Besides the water quality issues, the ongoing research at Evides will focus on the effect of the floating solar installation on algae, microbiological and chemical parameters, birds, aquatic flora and fauna, and also look into possibilities of applying alternative storage possibilities using hydrogen.</p

Removal of polar organic micropollutants by pilot-scale reverse osmosis drinking water treatment

The robustness of reverse osmosis (RO) against polar organic micropollutants (MPs) was investigated in pilot-scale drinking water treatment. Experiments were carried in hypoxic conditions to treat a raw anaerobic riverbank filtrate spiked with a mixture of thirty model compounds. The chemicals were selected from scientific literature data based on their relevance for the quality of freshwater systems, RO permeate and drinking water. MPs passage and the influence of permeate flux were evaluated with a typical low-pressure RO membrane and quantified by liquid chromatography coupled to high-resolution mass spectrometry. A strong inverse correlation between size and passage of neutral hydrophilic compounds was observed. This correlation was weaker for moderately hydrophobic MPs. Anionic MPs displayed nearly no passage due to electrostatic repulsion with the negatively charged membrane surface, whereas breakthrough of small cationic MPs could be observed. The passage figures observed for the investigated set of MPs ranged from less than 1%–25%. Statistical analysis was performed to evaluate the relationship between physicochemical properties and passage. The effects of permeate flux were more pronounced for small neutral MPs, which displayed a higher passage after a pressure drop.</p