Brownian Dynamics of a Sphere Between Parallel Walls

We describe direct imaging measurements of a colloidal sphere's diffusion between two parallel surfaces. The dynamics of this deceptively simple hydrodynamically coupled system have proved difficult to analyze. Comparison with approximate formulations of a confined sphere's hydrodynamic mobility reveals good agreement with both a leading-order superposition approximation as well as a more general all-images stokeslet analysis.Comment: 4 pages, 3 figures, REVTeX with PostScript figure

The Inception of a Prediabetes Prevention Program in County Government

With the increasing prevalence and high cost of treatment, diabetes places an enormous demand on economic resources. To combat this issue and rising health care costs,Cleveland County Government took a proactive approach and partnered with its local YMCA. The YMCA was contracted to provide Prediabetes Prevention and Diabetes Control program classes to County employees. The programs were designed to (a) decrease the A1c level of program participants, (b) lower health care costs for the County, and (c) provide education about prevention and maintenance. The ultimate goal of the program was to assist county administration and staff in their efforts to improve the quality and effectiveness of the program while also determining if the County needed to renew the 3-year contract. This evaluation focuses on the benefits of the program and the success of program participants based on biometric screening results and includes a review and analysis of survey data collected from program participants. Results indicate that after the first year, the County saved approximately $550,000 in health care costs by offering the program. Biometric screening results for program participants significantly improved with 77 employees moving from a prediabetes range glucose to a normal range glucose and with 246 employees improving A1c (blood glucose) metrics from the previous year

Guidance, flight mechanics and trajectory optimization. Volume 11 - Guidance equations for orbital operations

Mathematical formulation of guidance equations and solutions for orbital space mission

Guidance, Flight Mechanics and Trajectory Optimization. Volume 5 - State Determination And/or Estimation

Guidance, flight mechanics, and trajectory optimizatio

Weak Long-Ranged Casimir Attraction in Colloidal Crystals

We investigate the influence of geometric confinement on the free energy of an idealized model for charge-stabilized colloidal suspensions. The mean-field Poisson-Boltzmann formulation for this system predicts pure repulsion among macroionic colloidal spheres. Fluctuations in the simple ions' distribution provide a mechanism for the macroions to attract each other at large separations. Although this Casimir interaction is long-ranged, it is too weak to influence colloidal crystals' dynamics.Comment: 5 pages 2 figures ReVTe

Blunted Cystine–Glutamate Antiporter Function in the Nucleus Accumbens Promotes Cocaine-induced Drug Seeking

Repeated cocaine alters glutamate neurotransmission, in part, by reducing cystine–glutamate exchange via system xc−, which maintains glutamate levels and receptor stimulation in the extrasynaptic compartment. In the present study, we undertook two approaches to determine the significance of plasticity involving system xc−. First, we examined whether the cysteine prodrug N-acetylcysteine attenuates cocaine-primed reinstatement by targeting system xc−. Rats were trained to self-administer cocaine (1 mg/kg/200 μl, i.v.) under extended access conditions (6 h/day). After extinction training, cocaine (10 mg/kg, i.p.) primed reinstatement was assessed in rats pretreated with N-acetylcysteine (0–60 mg/kg, i.p.) in the presence or absence of the system xc− inhibitor (S)-4-carboxyphenylglycine (CPG; 0.5 μM; infused into the nucleus accumbens). N-acetylcysteine attenuated cocaine-primed reinstatement, and this effect was reversed by co-administration of CPG. Secondly, we examined whether reduced system xc− activity is necessary for cocaine-primed reinstatement. To do this, we administered N-acetylcysteine (0 or 90 mg/kg, i.p.) prior to 12 daily self-administration sessions (1 mg/kg/200 μl, i.v.; 6 h/day) since this procedure has previously been shown to prevent reduced activity of system xc−. On the reinstatement test day, we then acutely impaired system xc− in some of the rats by infusing CPG (0.5 μM) into the nucleus accumbens. Rats that had received N-acetylcysteine prior to daily self-administration sessions exhibited diminished cocaine-primed reinstatement; this effect was reversed by infusing the cystine–glutamate exchange inhibitor CPG into the nucleus accumbens. Collectively these data establish system xc− in the nucleus accumbens as a key mechanism contributing to cocaine-primed reinstatement

The Importance of Broad Emission-Line Widths in Single Epoch Black Hole Mass Estimates

Estimates of the mass of super-massive black holes (BHs) in distant active galactic nuclei (AGNs) can be obtained efficiently only through single-epoch spectra, using a combination of their broad emission-line widths and continuum luminosities. Yet the reliability and accuracy of the method, and the resulting mass estimates, M_BH, remain uncertain. A recent study by Croom using a sample of SDSS, 2QZ and 2SLAQ quasars suggests that line widths contribute little information about the BH mass in these single-epoch estimates and can be replaced by a constant value without significant loss of accuracy. In this Letter, we use a sample of nearby reverberation-mapped AGNs to show that this conclusion is not universally applicable. We use the bulge luminosity (L_Bulge) of these local objects to test how well the known M_BH - L_Bulge correlation is recovered when using randomly assigned line widths instead of the measured ones to estimate M_BH. We find that line widths provide significant information about M_BH, and that for this sample, the line width information is just as significant as that provided by the continuum luminosities. We discuss the effects of observational biases upon the analysis of Croom and suggest that the results can probably be explained as a bias of flux-limited, shallow quasar samples.Comment: 10 text pages + 4 Figures + 1 Table. Accepted for publication in ApJ Letter

Optical shield: measuring viscosity of turbid fluids using optical tweezers

The viscosity of a fluid can be measured by tracking the motion of a suspended micron-sized particle trapped by optical tweezers. However, when the particle density is high, additional particles entering the trap compromise the tracking procedure and degrade the accuracy of the measurement. In this work we introduce an additional Laguerre–Gaussian, i.e. annular, beam surrounding the trap, acting as an optical shield to exclude contaminating particles