Differentiating the impact of anatomic and non-anatomic liver resection on early recurrence in patients with Hepatocellular Carcinoma

<p>Abstract</p> <p>Background</p> <p>For Hepatocellular Carcinoma (HCC) treated with hepatectomy, the extent of the resection margin remains controversial and data available on its effect on early tumor recurrence are very few and contradictory. The purpose of this study was to compare the impact of the type of resection (anatomic versus non-anatomic) on early intra-hepatic HCC recurrence in patients with solitary HCC and preserved liver function.</p> <p>Methods</p> <p>Among 53 patients with similar clinico-pathologic data who underwent curative liver resection for HCC between 2000 and 2006, 28 patients underwent anatomic resection of at least one liver segment and 25 patients underwent limited resection with a margin of at least 1 cm.</p> <p>Results</p> <p>After a close follow-up period of 24 months, no difference was detected in recurrence rates between the anatomic (35.7%) and the non-anatomic (40%) groups in either univariate (<it>p = 0.74</it>) and multivariate (<it>p = 0.65</it>) analysis. Factors contributing to early recurrence were tumor size (<it>p = 0.012</it>) and tumor stage including vascular invasion (<it>p = 0.009</it>).</p> <p>Conclusion</p> <p>The choice of the type of resection for HCC should be based on the maintenance of adequate hepatic reserve. The type of resection (anatomic vs non-anatomic) was found not to be a risk factor for early tumor recurrence.</p

A review of lifestyle and environment risk factors for pancreatic cancer.

Pancreatic cancer (PaCa) is one of the deadliest cancers known and its incidence is increasing in the developed countries. Because of the lack of biomarkers that allow early detection and the tendency of the disease to be asymptomatic, the diagnosis comes often too late for effective surgical or chemotherapy intervention. Lifestyle factors, that may cause common genetic modifications occurring in the disease, interfere with pancreatic physiology or function, and play a role in PaCa development, have been of concern recently, since a strategy to prevent this severe cancer is needed. This review identifies the latest evidences related to increased risk of developing PaCa due to dietary habits such as high alcohol, fructose and red or processed meat intake, and pathological conditions such as diabetes, obesity and infections in addition to stress and smoking behaviour. It aims to highlight the importance of intervening on modifiable risk factors: the action on these factors could prevent a considerable number of new cases of PaCa

First observation of 55,56Zn

In an experiment at the SISSI/LISE3 facility of GANIL, the most proton-rich zinc isotopes 55,56Zn have been observed for the first time. The experiment was performed using a high-intensity 58Ni beam at 74.5 MeV/nucleon impinging on a nickel target. The identification of 55,56Zn opens the way to 54Zn, a good candidate for two-proton radioactivity according to theoretical predictions.Comment: 2 pages, 1 figure, accepted for publication in Eur. Phys. J.

Decay of proton-rich nuclei between 39Ti and 49Ni

Decay studies of very neutron-deficient nuclei ranging from 39Ti to 49Ni have been performed during a projectile fragmentation experiment at the GANIL/LISE3 separator. For all nuclei studied in this work, 39,40Ti, 42,43Cr, 46Mn, 45,46,47Fe and 49Ni, half-lives and decay spectra have been measured. In a few cases, gamma coincidence measurements helped to successfully identify the initial and final states of transitions. In these cases, partial decay scheme are proposed. For the most exotic isotopes, 39Ti, 42Cr, 45Fe and 49Ni, which are candidates for two-proton radioactivity from the ground state, no clear evidence of this process is seen in our spectra and we conclude rather on a delayed particle decay.Comment: 12 pages, 15 figures, submitted for publication in Eur. Phys. J.

On the two-proton emission for Fe45 - a new type of radioactivity

In an experiment at the SISSI-LISE3 facility of GANIL, the decay of the proton drip-line nucleus Fe45 has been studied after projectile fragmentation of a Ni58 primary beam at 75 MeV/nucleon impinging on a natural nickel target. Fragment-implantation events have been correlated with radioactive decay events in a 16x16 pixel silicon strip detector on an event-by-event basis. The decay-energy spectrum of Fe45 implants shows a distinct peak at (1.06+/-0.04)MeV with a half-life of T1/2 = (4.7+3.4-1.4)ms. None of the events in this peak is in coincidence with beta particles which were searched for in a detector next to the implantation detector. For a longer correlation interval, daughter decays of the two-proton daughter Cr43 can be observed after Fe45 implantation. The decay energy for Fe45 agrees nicely with several theoretical predictions for two-proton emission. Barrier-penetration calculations slightly favour a di-proton emission picture over an emission of two individual protons and point thus to a He2 emission mode.Comment: 4 pages, 5 figures, sumitted to PR

Direct and sequential radiative three-body reaction rates at low temperatures

We investigate the low-temperature reaction rates for radiative capture processes of three particles. We compare direct and sequential capture mechanisms and rates using realistic phenomenological parametrizations of the corresponding photodissociation cross sections.Energy conservation prohibits sequential capture for energies smaller than that of the intermediate two-body structure. A finite width or a finite temperature allows this capture mechanism. We study generic effects of positions and widths of two- and three-body resonances for very low temperatures. We focus on nuclear reactions relevant for astrophysics, and we illustrate with realistic estimates for the $\alpha$-$\alpha$-$\alpha$ and $\alpha$-$\alpha$-$n$ radiative capture processes. The direct capture mechanism leads to reaction rates which for temperatures smaller than 0.1 GK can be several orders of magnitude larger than those of the NACRE compilation.Comment: To be published in European Physical Journal

On the discovery of doubly-magic 48^{48}Ni

The paper reports on the first observation of doubly-magic Nickel-48 in an experimental at the SISSI/LISE3 facility of GANIL. Four Nickel-48 isotopes were identified. In addition, roughly 100 Nickel-49, 50 Iron-45, and 290 Chromium-42 isotopes were observed. This opens the possibility to search for two-proton emission from these nuclei.Comment: 4 pages, 3 figures, accepted for publication in Phys. Rev. Let

Beta-decay properties of 25^{25}Si and 26^{26}P

The $\beta$-decay properties of the neutron-deficient nuclei $^{25}$Si and $^{26}$P have been investigated at the GANIL/LISE3 facility by means of charged-particle and $\gamma$-ray spectroscopy. The decay schemes obtained and the Gamow-Teller strength distributions are compared to shell-model calculations based on the USD interaction. B(GT) values derived from the absolute measurement of the $\beta$-decay branching ratios give rise to a quenching factor of the Gamow-Teller strength of 0.6. A precise half-life of 43.7 (6) ms was determined for $^{26}$P, the $\beta$- (2)p decay mode of which is described