687 research outputs found
GeoCLEF 2007: the CLEF 2007 cross-language geographic information retrieval track overview
GeoCLEF ran as a regular track for the second time within the Cross
Language Evaluation Forum (CLEF) 2007. The purpose of GeoCLEF is to test
and evaluate cross-language geographic information retrieval (GIR): retrieval
for topics with a geographic specification. GeoCLEF 2007 consisted of two sub
tasks. A search task ran for the third time and a query classification task was
organized for the first. For the GeoCLEF 2007 search task, twenty-five search
topics were defined by the organizing groups for searching English, German,
Portuguese and Spanish document collections. All topics were translated into
English, Indonesian, Portuguese, Spanish and German. Several topics in 2007
were geographically challenging. Thirteen groups submitted 108 runs. The
groups used a variety of approaches. For the classification task, a query log
from a search engine was provided and the groups needed to identify the
queries with a geographic scope and the geographic components within the
local queries
GeoCLEF 2006: the CLEF 2006 Ccross-language geographic information retrieval track overview
After being a pilot track in 2005, GeoCLEF advanced to be a regular track within CLEF 2006. The
purpose of GeoCLEF is to test and evaluate cross-language geographic information retrieval (GIR): retrieval for
topics with a geographic specification. For GeoCLEF 2006, twenty-five search topics were defined by the
organizing groups for searching English, German, Portuguese and Spanish document collections. Topics were
translated into English, German, Portuguese, Spanish and Japanese. Several topics in 2006 were significantly
more geographically challenging than in 2005. Seventeen groups submitted 149 runs (up from eleven groups and
117 runs in GeoCLEF 2005). The groups used a variety of approaches, including geographic bounding boxes,
named entity extraction and external knowledge bases (geographic thesauri and ontologies and gazetteers)
Molecular phylogenies support taxonomic revision of three species of Laurencia (Rhodomelaceae, Rhodophyta), with the description of a new genus
Systematics of the Laurencia complex was investigated using a taxon-rich data set including the chloroplast ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit (rbcL) gene only and a character-rich data set combining the mitochondrial cytochrome oxidase 1 (COI-5P), the rbcL marker, and the nuclear large subunit of the ribosomal operon (LSU). Bayesian and ML analyses of these data sets showed that three species hitherto placed in the genus Laurencia were not closely related to Laurencia sensu stricto. Laurencia caspica was the sister group of the remaining Osmundea species, L. crustiformans joined Palisada and L. flexilis consisted of an independent lineage. In light of these results a new genus, Ohelopapa, was proposed to accommodate L. flexilis. This new genus is morphologically characterized by four pericentral cells in each vegetative axial segment, however it lacks corps en cerise in cortical cells and secondary pit connections between cortical cells which are characteristic in Laurencia. Three novel combinations are proposed to render the classification closer to a natural system: Ohelopapa flexilis, Osmundea caspica, and Palisada crustiformans
Interleukin-2 therapy in patients with HIV infection
BACKGROUND
Used in combination with antiretroviral therapy, subcutaneous recombinant interleukin-2 raises CD4+ cell counts more than does antiretroviral therapy alone. The clinical implication of these increases is not known.
METHODS
We conducted two trials: the Subcutaneous Recombinant, Human Interleukin-2 in HIV-Infected Patients with Low CD4+ Counts under Active Antiretroviral Therapy (SILCAAT) study and the Evaluation of Subcutaneous Proleukin in a Randomized International Trial (ESPRIT). In each, patients infected with the human immunodeficiency virus (HIV) who had CD4+ cell counts of either 50 to 299 per cubic millimeter (SILCAAT) or 300 or more per cubic millimeter (ESPRIT) were randomly assigned to receive interleukin-2 plus antiretroviral therapy or antiretroviral therapy alone. The interleukin-2 regimen consisted of cycles of 5 consecutive days each, administered at 8-week intervals. The SILCAAT study involved six cycles and a dose of 4.5 million IU of interleukin-2 twice daily; ESPRIT involved three cycles and a dose of 7.5 million IU twice daily. Additional cycles were recommended to maintain the CD4+ cell count above predefined target levels. The primary end point of both studies was opportunistic disease or death from any cause.
RESULTS
In the SILCAAT study, 1695 patients (849 receiving interleukin-2 plus antiretroviral therapy and 846 receiving antiretroviral therapy alone) who had a median CD4+ cell count of 202 cells per cubic millimeter were enrolled; in ESPRIT, 4111 patients (2071 receiving interleukin-2 plus antiretroviral therapy and 2040 receiving antiretroviral therapy alone) who had a median CD4+ cell count of 457 cells per cubic millimeter were enrolled. Over a median follow-up period of 7 to 8 years, the CD4+ cell count was higher in the interleukin-2 group than in the group receiving antiretroviral therapy alone--by 53 and 159 cells per cubic millimeter, on average, in the SILCAAT study and ESPRIT, respectively. Hazard ratios for opportunistic disease or death from any cause with interleukin-2 plus antiretroviral therapy (vs. antiretroviral therapy alone) were 0.91 (95% confidence interval [CI], 0.70 to 1.18; P=0.47) in the SILCAAT study and 0.94 (95% CI, 0.75 to 1.16; P=0.55) in ESPRIT. The hazard ratios for death from any cause and for grade 4 clinical events were 1.06 (P=0.73) and 1.10 (P=0.35), respectively, in the SILCAAT study and 0.90 (P=0.42) and 1.23 (P=0.003), respectively, in ESPRIT.
CONCLUSIONS
Despite a substantial and sustained increase in the CD4+ cell count, as compared with antiretroviral therapy alone, interleukin-2 plus antiretroviral therapy yielded no clinical benefit in either study. (ClinicalTrials.gov numbers, NCT00004978 [ESPRIT] and NCT00013611 [SILCAAT study].
A Survey of Volunteered Open Geo-Knowledge Bases in the Semantic Web
Over the past decade, rapid advances in web technologies, coupled with
innovative models of spatial data collection and consumption, have generated a
robust growth in geo-referenced information, resulting in spatial information
overload. Increasing 'geographic intelligence' in traditional text-based
information retrieval has become a prominent approach to respond to this issue
and to fulfill users' spatial information needs. Numerous efforts in the
Semantic Geospatial Web, Volunteered Geographic Information (VGI), and the
Linking Open Data initiative have converged in a constellation of open
knowledge bases, freely available online. In this article, we survey these open
knowledge bases, focusing on their geospatial dimension. Particular attention
is devoted to the crucial issue of the quality of geo-knowledge bases, as well
as of crowdsourced data. A new knowledge base, the OpenStreetMap Semantic
Network, is outlined as our contribution to this area. Research directions in
information integration and Geographic Information Retrieval (GIR) are then
reviewed, with a critical discussion of their current limitations and future
prospects
Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells
Immune cells are important components of the tumor microenvironment and influence tumor growth and evolution at all stages of carcinogenesis. Notably, it is now well established that the immune infiltrate in human tumors can correlate with prognosis and response to therapy. The analysis of the immune infiltrate in the tumor microenvironment has become a major challenge for the classification of patients and the response to treatment. The co-expression of inhibitory receptors such as Program Cell Death Protein 1 (PD1; also known as CD279), Cytotoxic T Lymphocyte Associated Protein 4 (CTLA-4), T-Cell Immunoglobulin and Mucin Containing Protein-3 (Tim-3; also known as CD366), and Lymphocyte Activation Gene 3 (Lag-3; also known as CD223), is a hallmark of T cell exhaustion. We developed a multiparametric in situ immunofluorescence staining to identify and quantify at the cellular level the co-expression of these inhibitory receptors. On a retrospective series of frozen tissue of renal cell carcinomas (RCC), using a fluorescence multispectral imaging technology coupled with an image analysis software, it was found that co-expression of PD-1 and Tim-3 on tumor infiltrating CD8 T cells is correlated with a poor prognosis in RCC. To our knowledge, this represents the first study demonstrating that this automated multiplex in situ technology may have some clinical relevance
- âŠ