269 research outputs found
On the Conformal forms of the Robertson-Walker metric
All possible transformations from the Robertson-Walker metric to those
conformal to the Lorentz-Minkowski form are derived. It is demonstrated that
the commonly known family of transformations and associated conformal factors
are not exhaustive and that there exists another relatively less well known
family of transformations with a different conformal factor in the particular
case that K = -1. Simplified conformal factors are derived for the special case
of maximally-symmetric spacetimes. The full set of all possible
cosmologically-compatible conformal forms is presented as a comprehensive
table. A product of the analysis is the determination of the set-theoretical
relationships between the maximally symmetric spacetimes, the Robertson-Walker
spacetimes, and functionally more general spacetimes. The analysis is preceded
by a short historical review of the application of conformal metrics to
Cosmology.Comment: Historical review added. Accepted by J. Math. Phy
The echinoderm innate humoral immune response
Abstract: Multicellular organisms have an immune system, which is essential for the survival of living beings. Interest in the immune system has been expanded since common characteristics of innate immunity between Drosophila melanogaster (Meigen, 1830) and mammals were discovered in the 1980. Since then, immunology has mainly focused on the adaptive immune system that seems to be restricted to vertebrates. Unlike the innate immunity, the adaptive one is acquired after exposure to a specific antigen (Ag) and includes: antigen-presenting cells such as macrophages, proliferation of B and T lymphocytes, Ag-specific antibody/cytokine production and immunological memory. Innate immunity is instead a process of cellular defense at low specificity, which is designed to prevent and combat infectious agents that penetrate at the tissue level, and may be the only form of immunity present in invertebrates such as sea urchins. The immune system of invertebrates acts through (i) cellular components (cell-mediated immunity) in which the effectors of defense reactions are represented by immune cells; (ii) soluble factors (humoral immunity), secreted by the immune cells, such as lectins, agglutinins, lysins, antimicrobial peptides and the prophenoloxidase (proPO) activating system, which act in parallel with the immune cells to fight pathogens and other foreign substances. Here we aim to deepen the study on humoral immunity of invertebrates, especially referring to the phylum Echinodermata because of its features shared with protostomes and other deuterostomes, and suggesting a key step during evolution
Dynamics of Charged Particles in the Radio Emission Region of Pulsar Magnetosphere
We consider the classical picture of three dimensional motion of charged
particles in pulsar magnetosphere. We adopt a perturbative method to solve the
equation of motion, and find the trajectory of particles as they move along the
rotating dipolar magnetic field lines. Our aim is to study the influence of
rotation on the pulsar radio emission by considering the constrained motion of
particles along the open dipolar magnetic field lines. We find that the
rotation induces a significant curvature into the particle trajectories. Our
model predicts the intensity on leading side dominates over that of trailing
side. We expect that if there is any curvature induced radio emission from the
region close to the magnetic axis then it must be due to the rotation induced
curvature. Our model predicts the radius--to--frequency mapping (RFM) in the
core emissions.Comment: 16 pages, 11 figures, Accepted for publication in Astronomy and
Astrophysics (2007
Predictors of long-term pain and disability in patients with low back pain investigated by magnetic resonance imaging: A longitudinal study
<p>Abstract</p> <p>Background</p> <p>It is possible that clinical outcome of low back pain (LBP) differs according to the presence or absence of spinal abnormalities on magnetic resonance imaging (MRI), in which case there could be value in using MRI findings to refine case definition of LBP in epidemiological research. We therefore conducted a longitudinal study to explore whether spinal abnormalities on MRI for LBP predict prognosis after 18 months.</p> <p>Methods</p> <p>A consecutive series of patients aged 20-64 years, who were investigated by MRI because of mechanical LBP (median duration of current episode 16.2 months), were identified from three radiology departments, and those who agreed completed self-administered questionnaires at baseline and after a mean follow-up period of 18.5 months (a mean of 22.2 months from MRI investigation). MRI scans were assessed blind to other clinical information, according to a standardised protocol. Associations of baseline MRI findings with pain and disability at follow-up, adjusted for treatment and for other potentially confounding variables, were assessed by Poisson regression and summarised by prevalence ratios (PRs) with their 95% confidence intervals (CIs).</p> <p>Results</p> <p>Questionnaires were completed by 240 (74%) of the patients who had agreed to be followed up. Among these 111 men and 129 women, 175 (73%) reported LBP in the past four weeks, 89 (37%) frequent LBP, and 72 (30%) disabling LBP. In patients with initial disc degeneration there was an increased risk of frequent (PR 1.3, 95%CI 1.0-1.9) and disabling LBP (PR 1.7, 95%CI 1.1-2.5) at follow-up. No other associations were found between MRI abnormalities and subsequent outcome.</p> <p>Conclusions</p> <p>Our findings suggest that the MRI abnormalities examined are not major predictors of outcome in patients with LBP. They give no support to the use of MRI findings as a way of refining case definition for LBP in epidemiological research.</p
A Kinematical Approach to Conformal Cosmology
We present an alternative cosmology based on conformal gravity, as originally
introduced by H. Weyl and recently revisited by P. Mannheim and D. Kazanas.
Unlike past similar attempts our approach is a purely kinematical application
of the conformal symmetry to the Universe, through a critical reanalysis of
fundamental astrophysical observations, such as the cosmological redshift and
others. As a result of this novel approach we obtain a closed-form expression
for the cosmic scale factor R(t) and a revised interpretation of the space-time
coordinates usually employed in cosmology. New fundamental cosmological
parameters are introduced and evaluated. This emerging new cosmology does not
seem to possess any of the controversial features of the current standard
model, such as the presence of dark matter, dark energy or of a cosmological
constant, the existence of the horizon problem or of an inflationary phase.
Comparing our results with current conformal cosmologies in the literature, we
note that our kinematic cosmology is equivalent to conformal gravity with a
cosmological constant at late (or early) cosmological times. The cosmic scale
factor and the evolution of the Universe are described in terms of several
dimensionless quantities, among which a new cosmological variable delta emerges
as a natural cosmic time. The mathematical connections between all these
quantities are described in details and a relationship is established with the
original kinematic cosmology by L. Infeld and A. Schild. The mathematical
foundations of our kinematical conformal cosmology will need to be checked
against current astrophysical experimental data, before this new model can
become a viable alternative to the standard theory.Comment: Improved version, with minor changes. 58 pages, including 7 figures
and one table. Accepted for publication in General Relativity and Gravitation
(GERG
Proximal major limb amputations – a retrospective analysis of 45 oncological cases
<p>Abstract</p> <p>Background</p> <p>Proximal major limb amputations due to malignant tumors have become rare but are still a valuable treatment option in palliation and in some cases can even cure. The aim of this retrospective study was to analyse outcome in those patients, including the postoperative course, survival, pain, quality of life, and prosthesis usage.</p> <p>Methods</p> <p>Data of 45 consecutive patients was acquired from patient's charts and contact to patients, and general practitioners. Patients with interscapulothoracic amputation (n = 14), shoulder disarticulation (n = 13), hemipelvectomy (n = 3) or hip disarticulation (n = 15) were included.</p> <p>Results</p> <p>The rate of proximal major limb amputations in patients treated for sarcoma was 2.3% (37 out of 1597). Survival for all patients was 42.9% after one year and 12.7% after five years. Survival was significantly better in patients with complete tumor resections. Postoperative chemotherapy and radiation did not prolong survival. Eighteen percent of the patients with malignant disease developed local recurrence. In 44%, postoperative complications were observed. Different modalities of postoperative pain management and the site of the amputation had no significant influence on long-term pain assessment and quality of life. Eighty-seven percent suffered from phantom pain, 15.6% considered their quality of life worse than before the operation. Thirty-two percent of the patients who received a prosthesis used it regularly.</p> <p>Conclusion</p> <p>Proximal major limb amputations severely interfere with patients' body function and are the last, albeit valuable, option within the treatment concept of extremity malignancies or severe infections. Besides short survival, high complication rates, and postoperative pain, patients' quality of life can be improved for the time they have remaining.</p
Reliability of MRI findings in candidates for lumbar disc prosthesis
Introduction: Limited reliability data exist for localised magnetic resonance imaging (MRI) findings relevant to planning of treatment with lumbar disc prosthesis and later outcomes. We assessed the reliability of such findings in chronic low back pain patients who were accepted candidates for disc prosthesis. Methods: On pretreatment MRI of 170 patients (mean age 41 years; 88 women), three experienced radiologists independently rated Modic changes, disc findings and facet arthropathy at L3/L4, L4/L5 and L5/S1. Two radiologists rerated 126 examinations. For each MRI finding at each disc level, agreement was analysed using the kappa statistic and differences in prevalence across observers using a fixed effects model. Results: All findings at L3/L4 and facet arthropathy at L5/S1 had a mean prevalence <10% across observers and were not further analysed, ensuring interpretable kappa values. Overall interobserver agreement was generally moderate or good (kappa 0.40–0.77) at L4–S1 for Modic changes, nucleus pulposus signal, disc height (subjective and measured), posterior high-intensity zone (HIZ) and disc contour, and fair (kappa 0.24) at L4/L5 for facet arthropathy. Posterior HIZ at L5/S1 and severely reduced subjective disc height at L4/L5 differed up to threefold in prevalence between observers (p< 0.0001). Intraobserver agreement was mostly good or very good (kappa 0.60–1.00). Conclusion: In candidates for disc prosthesis, mostly moderate interobserver agreement is expected for localised MRI findings
Regional Decline of Coral Cover in the Indo-Pacific: Timing, Extent, and Subregional Comparisons
A number of factors have recently caused mass coral mortality events in all of the world's tropical oceans. However, little is known about the timing, rate or spatial variability of the loss of reef-building corals, especially in the Indo-Pacific, which contains 75% of the world's coral reefs.We compiled and analyzed a coral cover database of 6001 quantitative surveys of 2667 Indo-Pacific coral reefs performed between 1968 and 2004. Surveys conducted during 2003 indicated that coral cover averaged only 22.1% (95% CI: 20.7, 23.4) and just 7 of 390 reefs surveyed that year had coral cover >60%. Estimated yearly coral cover loss based on annually pooled survey data was approximately 1% over the last twenty years and 2% between 1997 and 2003 (or 3,168 km(2) per year). The annual loss based on repeated measures regression analysis of a subset of reefs that were monitored for multiple years from 1997 to 2004 was 0.72 % (n = 476 reefs, 95% CI: 0.36, 1.08).The rate and extent of coral loss in the Indo-Pacific are greater than expected. Coral cover was also surprisingly uniform among subregions and declined decades earlier than previously assumed, even on some of the Pacific's most intensely managed reefs. These results have significant implications for policy makers and resource managers as they search for successful models to reverse coral loss
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