391 research outputs found

    Minimal Overlap Rules for Bankruptcy

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    This paper introduces a new way of representing bankruptcy rules.These representations are used to show that the minimal overlap rule is a composition of the Ibn Ezra rule and the constrained equal losses rule.The residual minimal overlap rule is analysed as an alternative extension of the Ibn Ezra rule, by using a composition with the constrained equal awards rule.bankruptcy;representations;Ibn Ezra rule;minimum overlap rule;duality

    Minimal Overlap Rules for Bankruptcy

    Get PDF
    This paper introduces a new way of representing bankruptcy rules.These representations are used to show that the minimal overlap rule is a composition of the Ibn Ezra rule and the constrained equal losses rule.The residual minimal overlap rule is analysed as an alternative extension of the Ibn Ezra rule, by using a composition with the constrained equal awards rule.

    Development of the Renewal on the Standing Rock Sioux Reservation Project

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    On the Ground•The Standing Rock Sioux Reservation comprises 2.3 million acres, primarily rangeland, straddling the North Dakota–South Dakota border.•Natural resource management is economically and culturally important to the Standing Rock community.•Respecting traditional ways of thinking and placing stakeholders and their needs at the center are key aspects of project development.•Native Americans were the original natural resource managers on our rangelands, and their thoughts and expertise can provide guidance to rangeland managers now and in the future

    Using Goal- and Grip-Related Information for Understanding the Correctness of Other’s Actions: An ERP Study

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    Detecting errors in other’s actions is of pivotal importance for joint action, competitive behavior and observational learning. Although many studies have focused on the neural mechanisms involved in detecting low-level errors, relatively little is known about error-detection in everyday situations. The present study aimed to identify the functional and neural mechanisms whereby we understand the correctness of other’s actions involving well-known objects (e.g. pouring coffee in a cup). Participants observed action sequences in which the correctness of the object grasped and the grip applied to a pair of objects were independently manipulated. Observation of object violations (e.g. grasping the empty cup instead of the coffee pot) resulted in a stronger P3-effect than observation of grip errors (e.g. grasping the coffee pot at the upper part instead of the handle), likely reflecting a reorienting response, directing attention to the relevant location. Following the P3-effect, a parietal slow wave positivity was observed that persisted for grip-errors, likely reflecting the detection of an incorrect hand-object interaction. These findings provide new insight in the functional significance of the neurophysiological markers associated with the observation of incorrect actions and suggest that the P3-effect and the subsequent parietal slow wave positivity may reflect the detection of errors at different levels in the action hierarchy. Thereby this study elucidates the cognitive processes that support the detection of action violations in the selection of objects and grips

    Alginate microspheres containing temperature sensitive liposomes (TSL) for MR-guided embolization and triggered release of doxorubicin

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    Objective The objective of this study was to develop and characterize alginate microspheres suitable for embolization with on-demand triggered doxorubicin (DOX) release and whereby the microspheres as well as the drug releasing process can be visualized in vivo using MRI. Methods and Findings For this purpose, barium crosslinked alginate microspheres were loaded with temperature sensitive liposomes (TSL/TSL-Ba-ms), which release their payload upon mild hyperthermia. These TSL contained DOX and [Gd(HPDO3A)(H2O)], a T1 MRI contrast agent, for real time visualization of the release. Empty alginate microspheres crosslinked with holmium ions (T2* MRI contrast agent, Ho-ms) were mixed with TSL-Ba-ms to allow microsphere visualization. TSL-Ba-ms and Ho-ms were prepared with a homemade spray device and sized by sieving. Encapsulation of TSL in barium crosslinked microspheres changed the triggered release properties only slightly: 95% of the loaded DOX was released from free TSL vs. 86% release for TSL-Ba-ms within 30 seconds in 50% FBS at 42°C. TSL-Ba-ms (76 ± 41 μm) and Ho-ms (64 ± 29 μm) had a comparable size, which most likely will result in a similar in vivo tissue distribution after an i.v. co-injection and therefore Ho-ms can be used as tracer for the TSL-Ba-ms. MR imaging of a TSL-Ba-ms and Ho-ms mixture (ratio 95:5) before and after hyperthermia allowed in vitro and in vivo visualization of microsphere deposition (T2*-weighted images) as well as temperature-triggered release (T1-weighted images). The [Gd(HPDO3A)(H2O)] release and clusters of microspheres containing holmium ions were visualized in a VX2 tumor model in a rabbit using MRI. Conclusions In conclusion, these TSL-Ba-ms and Ho-ms are promising systems for real-time, MR-guided embolization and triggered release of drugs in vivo
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