Efecto de la raza y el sistema de lactancia sobre el color de la carne de cabritos de 5 razas españolas

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EP-1364: Proposal of thermal neutron detector stability for peripheral dose estimation in clinac at a novel neutron facility

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Efecto de la raza y el sistema de lactancia sobre el ph y la textura de la carne de cabritos de 5 razas españolas: abstract

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Calidad de carne de 7 razas españolas de ganado bovino vinculadas a su sistema de producción

En España, de modo general, el consumidor de carne de vacuno le da poca importancia a la raza en comparación con otros países Europeos, a pesar de que la misma influye en otras características que sí considera relevantes como el aspecto (color, grasa intramuscular) o la terneza. Las razas bovinas rústicas y locales españolas están ligadas a una región geográfica particular y a un sistema de erra tradicional, donde varios factores como la edad y peso al sacrificio, el sexo, el grado de engrasamiento, el manejo, la alimentación y el tratamiento post-sacrificio intervienen conjuntamente en la definición de cada producto. Estos productos suelen promocionarse a través de denominaciones de origen o marcas de calidad que, por otro lado, permiten al consumidor reducir la incertidumbre cuando compran alimentos, ya que están asociadas a ciertas características sensoriales y/o procesos productivos distintivos. Algunos autores han descrito la calidad de canal (Piedraflta et al., 2003) y las características bioquímicas (Gil et al., 2001) y sensoriales (Serra et al., 2008) de varias razas españolas vinculadas al sistema de producción, de modo que este trabajo se centra en la textura de la carne evaluada instrumentalmente y en algunas de sus características químicas. En: https://calidadcarnecita.wordpress.com/2016/02/12/calidad-de-la-carne-de-7-razas-espanolas-vinculadas-a-sus-sistema-de-produccion

Results of the first user program on the Homogenous Thermal Neutron Source HOTNES (ENEA / INFN)

The HOmogeneous Thermal NEutron Source (HOTNES) is a new type of thermal neutron irradiation assembly developed by the ENEA-INFN collaboration. The facility is fully characterized in terms of neutron field and dosimetric quantities, by either computational and experimental methods. This paper reports the results of the first "HOTNES users program", carried out in 2016, and covering a variety of thermal neutron active detectors such as scintillators, solid-state, single crystal diamond and gaseous detectors

La race a-t-elle un effet sur la qualité sensorielle de la viande de jeune bovin?

Dans le cadre du consortium européen Gemqual, 436 jeunes bovins issus de 15 races bovines différentes ont été conduits dans des systèmes d'élevage similaires afin d'évaluer l'impact de la race sur la qualité organoleptique de la viande déterminée par analyse sensorielle. Une comparaison de deux méthodes statistiques pour traiter les données de l'analyse sensorielle a tout d'abord été réalisée. L'analyse de variance avec ou sans effet dégustateur a abouti à des résultats similaires indiquant que ce choix méthodologique n'est pas décisif pour l'interprétation des résultats. Une classification non supervisée (classification ascendante hiérarchique) a ensuite permis de classer les races en fonction de trois profils sensoriels sur la base de 4 descripteurs (tendreté, jutosité, intensité de flaveur et flaveur anormale). Elle permet de mettre en évidence 5 associations de races. : Les races Aberdeen Angus, Highland et Jersey, qui ont une teneur élevée en lipides dans le muscle étudié (Longissimus thoracis), se sont distinguées des autres races par une flaveur de bœuf plus élevée. Les races mixtes et rustiques, Simmental, Casina et Marchigiana, ont produit une viande significativement moins juteuse et moins tendre que celle des races sélectionnées pour la production de viande. Les trois autres associations suivantes rassemblent les races Limousine et Charolaise dont le profil semble assez proche, les races Pirenaica et Avilena tendres et fortement appréciées par les panélistes, les races Asturiana de los Valles et Piemontaise caractérisées par une flaveur anormale plus intense. Dans l'ensemble, malgré des différences significatives de caractéristiques de l'animal, de la carcasse et du muscle, les différences de qualité sensorielle entre la plupart des races étaient faibles, avec seulement des différences significatives entre les quelques races qui présentaient des profils sensoriels extrêmes (comme la Simmental et la Pirenaica).PublishedCet article correspond à une étude publiée dans Livestock Science 250 (2021) 104548. Elle démontre qu’il existe peu de différences de qualité sensorielle entre races bovines bien que les races rustiques ou mixtes tendent à produire une viande légèrement moins tendre et moins juteuse et les races les plus grasses une viande avec plus de goû

Mitochondrial Dysfunction and Apoptosis in Cumulus Cells of Type I Diabetic Mice

Impaired oocyte quality has been demonstrated in diabetic mice; however, the potential pathways by which maternal diabetes exerts its effects on the oocyte are poorly understood. Cumulus cells are in direct contact with the oocyte via gap junctions and provide essential nutrients to support oocyte development. In this study, we investigated the effects of maternal diabetes on the mitochondrial status in cumulus cells. We found an increased frequency of fragmented mitochondria, a decreased transmembrane potential and an aggregated distribution of mitochondria in cumulus cells from diabetic mice. Furthermore, while mitochondrial biogenesis in cumulus cells was induced by maternal diabetes, their metabolic function was disrupted as evidenced by lower ATP and citrate levels. Moreover, we present evidence suggesting that the mitochondrial impairments induced by maternal diabetes, at least in part, lead to cumulus cell apoptosis through the release of cytochrome c. Together the deleterious effects on cumulus cells may disrupt trophic and signaling interactions with the oocyte, contributing to oocyte incompetence and thus poor pregnancy outcomes in diabetic females

Transcriptomic profiling of host-parasite interactions in the microsporidian <i>Trachipleistophora hominis</i>

BACKGROUND: Trachipleistophora hominis was isolated from an HIV/AIDS patient and is a member of a highly successful group of obligate intracellular parasites. METHODS: Here we have investigated the evolution of the parasite and the interplay between host and parasite gene expression using transcriptomics of T. hominis-infected rabbit kidney cells. RESULTS: T. hominis has about 30 % more genes than small-genome microsporidians. Highly expressed genes include those involved in growth, replication, defence against oxidative stress, and a large fraction of uncharacterised genes. Chaperones are also highly expressed and may buffer the deleterious effects of the large number of non-synonymous mutations observed in essential T. hominis genes. Host expression suggests a general cellular shutdown upon infection, but ATP, amino sugar and nucleotide sugar production appear enhanced, potentially providing the parasite with substrates it cannot make itself. Expression divergence of duplicated genes, including transporters used to acquire host metabolites, demonstrates ongoing functional diversification during microsporidian evolution. We identified overlapping transcription at more than 100 loci in the sparse T. hominis genome, demonstrating that this feature is not caused by genome compaction. The detection of additional transposons of insect origin strongly suggests that the natural host for T. hominis is an insect. CONCLUSIONS: Our results reveal that the evolution of contemporary microsporidian genomes is highly dynamic and innovative. Moreover, highly expressed T. hominis genes of unknown function include a cohort that are shared among all microsporidians, indicating that some strongly conserved features of the biology of these enormously successful parasites remain uncharacterised. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12864-015-1989-z) contains supplementary material, which is available to authorized users

Estimation of neutron-equivalent dose in organs of patients undergoing radiotherapy by the use of a novel online digital detector.

Neutron peripheral contamination in patients undergoing high-energy photon radiotherapy is considered as a risk factor for secondary cancer induction. Organ-specific neutron-equivalent dose estimation is therefore essential for a reasonable assessment of these associated risks. This work aimed to develop a method to estimate neutron-equivalent doses in multiple organs of radiotherapy patients. The method involved the convolution, at 16 reference points in an anthropomorphic phantom, of the normalized Monte Carlo neutron fluence energy spectra with the kerma and energy-dependent radiation weighting factor. This was then scaled with the total neutron fluence measured with passive detectors, at the same reference points, in order to obtain the equivalent doses in organs. The latter were correlated with the readings of a neutron digital detector located inside the treatment room during phantom irradiation. This digital detector, designed and developed by our group, integrates the thermal neutron fluence. The correlation model, applied to the digital detector readings during patient irradiation, enables the online estimation of neutron-equivalent doses in organs. The model takes into account the specific irradiation site, the field parameters (energy, field size, angle incidence, etc) and the installation (linac and bunker geometry). This method, which is suitable for routine clinical use, will help to systematically generate the dosimetric data essential for the improvement of current risk-estimation models

Roadmap to DILI research in Europe. A proposal from COST action ProEuroDILINet

Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.In the current article the aims for a constructive way forward in Drug-Induced Liver Injury (DILI) are to highlight the most important priorities in research and clinical science, therefore supporting a more informed, focused, and better funded future for European DILI research. This Roadmap aims to identify key challenges, define a shared vision across all stakeholders for the opportunities to overcome these challenges and propose a high-quality research program to achieve progress on the prediction, prevention, diagnosis and management of this condition and impact on healthcare practice in the field of DILI. This will involve 1. Creation of a database encompassing optimised case report form for prospectively identified DILI cases with well-characterised controls with competing diagnoses, biological samples, and imaging data; 2. Establishing of preclinical models to improve the assessment and prediction of hepatotoxicity in humans to guide future drug safety testing; 3. Emphasis on implementation science and 4. Enhanced collaboration between drug-developers, clinicians and regulatory scientists. This proposed operational framework will advance DILI research and may bring together basic, applied, translational and clinical research in DILI.Peer reviewe