Strain-Rate Frequency Superposition in Large-Amplitude Oscillatory Shear

In a recent work, Wyss, {\it et.al.} [Phys. Rev. Lett., {\bf 98}, 238303 (2007)] have noted a property of `soft solids' under oscillatory shear, the so-called strain-rate frequency superposition (SRFS). We extend this study to the case of soft solids under large-amplitude oscillatory shear (LAOS). We show results from LAOS studies in a monodisperse hydrogel suspension, an aqueous gel, and a biopolymer suspension, and show that constant strain-rate frequency sweep measurements with soft solids can be superimposed onto master curves for higher harmonic moduli, with the {\it same} shift factors as for the linear viscoelastic moduli. We show that the behavior of higher harmonic moduli at low frequencies in constant strain-rate frequency sweep measurements is similar to that at large strain amplitudes in strain-amplitude sweep tests. We show surface plots of the harmonic moduli and the energy dissipation rate per unit volume in LAOS for soft solids, and show experimentally that the energy dissipated per unit volume depends on the first harmonic loss modulus alone, in both the linear and the nonlinear viscoelastic regime.Comment: 10 pages, 25 figures, accepted for publication in Physical Review E. Incorporates referee comment

Non-adaptive phenotypic plasticity: the effects of terrestrial and aquatic herbicides on larval salamander morphology and swim speed

Department of Biology, University of North Carolina, Chapel Hill, NC, USAPhenotypic plasticity, although ubiquitous, may not always be advantageous. Non-adaptive plasticity is likely to occur in response to novel environmental stress. Anthropogenic contaminants, such as herbicides, are novel stressors that are not present in the evolutionary history of most species. We investigated the pattern and consequences of phenotypic plasticity induced by four glyphosate-based herbicides (two terrestrial and two aquatic) in larvae of the spotted salamander, , by determining (1) whether the herbicides induced different morphologies; (2) if different morphologies translated to differences in burst swim performance; and (3) how induced individuals performed relative to non-induced controls. Different herbicide formulations led to the production of significantly different head and tail morphologies, and tail morphology correlated with fastest escape speed. However, escape speed did not vary among treatments. In addition, three out of four herbicide treatments experienced accelerated growth rates, in terms of the lateral size of tails, although the tail shapes were either similar to preliminary controls or intermediate between preliminary and final controls. These observations suggest that herbicide-induced morphology is a case of non-adaptive phenotypic plasticity, and that there is potentially a trade-off between growth and development for larvae exposed to different formulations. Understanding the functional significance of induced phenotypes is important for determining their importance in shaping an organism's ecological interactions and evolutionary trajectories. Furthermore, under different conditions, the morphological changes that we observed in response to exposure to herbicides might affect salamander fitness and influence population dynamics

Dependence of the Normalized Radar Cross Section of Water Waves on Bragg Wavelength-Wind Speed Sensitivity

Measurements of the normalized radar cross section (sigma(sup o)) made by the YSCAT ultrawideband scatterometer during an extended deployment on the Canada Centre for Inland Waters(CCIW) Research Tower located at Lake Ontario are analyzed and compared with anemometer wind measurements to study the sensitivity of (sigma(sup o)) to the wind speed as a function of the Bragg wavelength. This paper concentrates on upwind and downwind azimuth angles in the wind speed range of 4.5-12 m/s. While YSCAT collected measurements of sigma(sup o) at a variety of frequencies and incidence angles, this paper focuses on frequencies of 2.0, 3.05, 5.30, 10.02, and 14.0 GHz and incidence angles within the Bragg regime, 30-50 deg. Adopting a power law model to describe the relationship between sigma(sup o) and wind speed, both wind speed exponents and upwind/downwind (u/d) ratios of sigma(sup o) are found using least squares linear regression. The analysis of the wind speed exponents and u/d ratios show that shorter Bragg wavelengths (Lambda less than 4 cm) are the most sensitive to wind speed and direction. Additionally, vertical polarization (V-pol) sigma(sup o) is shown to be more sensitive to wind speed than horizontal polarization (H-pol) sigma(sup o), while the H-pol u/d ratio is larger than the V-pol u/d ratio

Believing is achieving: a longitudinal study of self-efficacy and positive affect in resettled refugees

Research has shown that self-efficacy can play an important role in recovery from trauma (Benight and Bandura 2004). We hypothesised that for refugees, whose (often traumatic) experiences pre- and post-resettlement have been linked to a decrease in their wellbeing (e.g., Aspinall and Watters 2010), self-efficacy would play a key role in improving wellbeing. This paper investigates the link between self-efficacy and positive affect among resettled refugees (N = 180). Research used mixed methods. The longitudinal survey with three time points confirmed that higher levels of general self-efficacy were consistently associated with better positive affect at later time points. The reverse effects, from positive affect to later self-efficacy, were not significant. In addition, qualitative interviews with a subsample provide suggestions as to how self-efficacy of refugees might be improved: that is, by improving access to employment and language classes, by clarifying how British social and cultural systems work, including the practical information necessary to navigate daily life, and by providing more opportunities to increase social networks, all suggesting the necessity of a proactive role of the receiving society

'Harder than other lessons but good': the effect of colleague collaboration on secondary English pupil engagement

Research examining the effects of collaborative planning in British secondary schools relates primarily to the effect it has on a teacher’s professional development. Researchers seldom focus on the impact it has on the pupils. This study was designed to understand the effect collaboratively planned lessons had on pupil engagement in a British secondary school. Transcripts from lessons observations, reflective diaries and field notes were analysed using thematic analysis (Braun & Clarke, 2006). One theme was identified: ‘Pupils’ Engagement with Differentiated Instruction’. This research concludes that the collaboratively planned lessons allowed some pupils to engage in learning better than individually planned lessons. The professional learning occurring from the planning process allowed teachers to collaboratively plan a lesson that was stronger than an individually planned lesson; the most successful teaching and learning took place when teachers adopted their colleagues’ suggestions, thus supporting some of the pupils’ engagement with learning. This is significant as the UK’s Independent Teacher Workload Review Group promotes collaborative planning as a method of reducing workload (Independent Teacher Workload Review Group, 2016). However, collaborative planning is only worth doing if evidence implies that it maintains and improves outcomes for pupils. Authors discuss implications and outline areas for future research

Mii-vitaliSe: a pilot randomised controlled trial of a home gaming system (Nintendo Wii) to increase activity levels, vitality and well-being in people with multiple sclerosis.

OBJECTIVES: While the health and well-being benefits of physical activity are recognised, people with multiple sclerosis (MS) often face greater barriers than the general population. The Nintendo Wii potentially offers a fun, convenient way of overcoming some of these. The aim was to test the feasibility of conducting a definitive trial of the effectiveness and cost-effectiveness of Mii-vitaliSe; a home-based, physiotherapist-supported Nintendo Wii intervention. DESIGN: A single-centre wait-list randomised controlled study. SETTING: MS service in secondary care. PARTICIPANTS: Ambulatory, relatively inactive people with clinically confirmed MS. INTERVENTION: Thirty participants were randomised to receive Mii-vitaliSe either immediately (for 12 months) or after a 6-month wait (for 6 months). Mii-vitaliSe consisted of two supervised Nintendo Wii familiarisation sessions in the hospital followed by home use (Wii Sports, Sports Resort and Fit Plus software) with physiotherapist support and personalised resources. OUTCOMES: Included self-reported physical activity levels, quality of life, mood, self-efficacy, fatigue and assessments of balance, gait, mobility and hand dexterity at baseline, 6 and 12 months. Interviews (n=25) explored participants' experiences and, at study end, the two Mii-vitaliSe facilitators' experiences of intervention delivery (main qualitative findings reported separately). RESULTS: Mean (SD) age was 49.3 (8.7) years, 90% female, with 47% diagnosed with MS <6 years ago and 60% new to active gaming. The recruitment rate was 31% (95% CI 20% to 44%). Outcome data were available for 29 (97%) at 6 months and 28 (93%) at 12 months. No serious adverse events were reported during the study. Qualitative data indicated that Mii-vitaliSe was well-received. Mean Wii use across both groups over the initial 6-month intervention period was twice a week for 27 min/day. Mean cost of delivering Mii-vitaliSe was £684 per person. DISCUSSION: Mii-vitaliSe appears acceptable and a future trial feasible and warranted. These findings will inform its design. TRIAL REGISTRATION: ISRCTN49286846

Genetic and morphological divergence between Littorina fabalis ecotypes in Northern Europe

Low dispersal marine intertidal species facing strong divergent selective pressures associated with steep environmental gradients have a great potential to inform us about local adaptation and reproductive isolation. Among these, gastropods of the genus Littorina offer a unique system to study parallel phenotypic divergence resulting from adaptation to different habitats related with wave exposure. In this study, we focused on two Littorina fabalis ecotypes from Northern European shores and compared patterns of habitat-related phenotypic and genetic divergence across three different geographic levels (local, regional and global). Geometric morphometric analyses revealed that individuals from habitats moderately exposed to waves usually present a larger shell size with a wider aperture than those from sheltered habitats. The phenotypic clustering of L. fabalis by habitat across most locations (mainly in terms of shell size) support an important role of ecology in morphological divergence. A genome scan based on amplified fragment length polymorphisms (AFLPs) revealed a heterogeneous pattern of differentiation across the genome between populations from the two different habitats, suggesting ecotype divergence in the presence of gene flow. The contrasting patterns of genetic structure between nonoutlier and outlier loci, and the decreased sharing of outlier loci with geographic distance among locations are compatible with parallel evolution of phenotypic divergence, with an important contribution of gene flow and/or ancestral variation. In the future, model-based inference studies based on sequence data across the entire genome will help unravelling these evolutionary hypotheses, improving our knowledge about adaptation and its influence on diversification within the marine realm.Peer reviewe

Absence of Chordin-like 1 Aids Motor Recovery in a Mouse Model of Stroke

Chordin-like 1 (Chrdl1) is an astrocyte-secreted protein that regulates synaptic maturation, and limits plasticity via GluA2-containing AMPA receptors (AMPARs). It was demonstrated that Chrdl1 expression is very heterogeneous throughout the brain, and it is enriched in astrocytes in cortical layers 2/3, with peak expression in the visual cortex at postnatal day 14. In response to ischemic stroke, Chrdl1 is upregulated during the acute and sub-acute phases in the peri-infarct region, potentially hindering recovery after stroke. Here, we used photothrombosis to model ischemic stroke in the motor cortex of adult male and female mice. In this study, we demonstrate that elimination of Chrdl1 in a global knock-out mouse reduces apoptotic cell death at early post-stroke stages and prevents ischemia-driven synaptic loss of AMPA receptors at later time points, all contributing to faster motor recovery. This suggests that synapse-regulating astrocyte-secreted proteins such as Chrdl1 have therapeutic potential to aid functional recovery after an ischemic injury

Overcoming challenges to data quality in the ASPREE clinical trial

© 2019 The Author(s). Background: Large-scale studies risk generating inaccurate and missing data due to the complexity of data collection. Technology has the potential to improve data quality by providing operational support to data collectors. However, this potential is under-explored in community-based trials. The Aspirin in reducing events in the elderly (ASPREE) trial developed a data suite that was specifically designed to support data collectors: the ASPREE Web Accessible Relational Database (AWARD). This paper describes AWARD and the impact of system design on data quality. Methods: AWARD's operational requirements, conceptual design, key challenges and design solutions for data quality are presented. Impact of design features is assessed through comparison of baseline data collected prior to implementation of key functionality (n = 1000) with data collected post implementation (n = 18,114). Overall data quality is assessed according to data category. Results: At baseline, implementation of user-driven functionality reduced staff error (from 0.3% to 0.01%), out-of-range data entry (from 0.14% to 0.04%) and protocol deviations (from 0.4% to 0.08%). In the longitudinal data set, which contained more than 39 million data values collected within AWARD, 96.6% of data values were entered within specified query range or found to be accurate upon querying. The remaining data were missing (3.4%). Participant non-attendance at scheduled study activity was the most common cause of missing data. Costs associated with cleaning data in ASPREE were lower than expected compared with reports from other trials. Conclusions: Clinical trials undertake complex operational activity in order to collect data, but technology rarely provides sufficient support. We find the AWARD suite provides proof of principle that designing technology to support data collectors can mitigate known causes of poor data quality and produce higher-quality data. Health information technology (IT) products that support the conduct of scheduled activity in addition to traditional data entry will enhance community-based clinical trials. A standardised framework for reporting data quality would aid comparisons across clinical trials