Semiflexible polymer conformation, distribution and migration in microcapillary flows

The flow behavior of a semiflexible polymer in microchannels is studied using Multiparticle Collision Dynamics (MPC), a particle-based hydrodynamic simulation technique. Conformations, distributions, and radial cross-streamline migration are investigated for various bending rigidities, with persistence lengths Lp in the range 0.5 < Lp/Lr < 30. The flow behavior is governed by the competition between a hydrodynamic lift force and steric wall-repulsion, which lead to migration away from the wall, and a locally varying flow-induced orientation, which drives polymer away from the channel center and towards the wall. The different dependencies of these effects on the polymer bending rigidity and the flow velocity results in a complex dynamical behavior. However, a generic effect is the appearance of a maximum in the monomer and the center-of-mass distributions, which occurs in the channel center for small flow velocities, but moves off-center at higher velocities.Comment: in press at J. Phys. Condens. Matte

Non-planar snake gaits: from Stigmatic-starts to Sidewinding

Of the vast variety of animal gaits, one of the most striking is the non-planar undulating helical motion of a sidewinder. But non-planar helical gaits are not limited to sidewinders. Here we report a new non-planar gait used as an escape strategy in juvenile anacondas (Eunectes notaeus). In the S(tigmatic)-start, named for its eponymous shape, transient locomotion arises when the snake writhes and bends out of the plane while rolling forward about its midsection without slippage. We present a mathematical model for an active non-planar filament that interacts anisotropically with a frictional substrate to quantify our observations and show that locomotion is due to a propagating localized pulse of a topological quantity, the link density. A phase diagram as a function of scaled body size and muscular torques shows that relatively light juveniles are capable of S-starts but heavy adults are not, consistent with our experimental observations. We further show theoretically that a periodic sequence of S-starts naturally leads to sidewinding. All together, our characterization of a novel escape strategy in snakes using non-planar gaits highlights the role of topology in locomotion, provides a phase diagram for gait feasibility as a function of body size, and shows that the S-start forms the fundamental kernel underlying sidewinding

The Role of Purported Mucoprotectants in Dealing with Irritable Bowel Syndrome, Functional Diarrhea, and Other Chronic Diarrheal Disorders in Adults

Chronic diarrhea is a frequent presenting symptom, both in primary care medicine and in specialized gastroenterology units. It is estimated that more than 5% of the global population suffers from chronic diarrhea. and that about 40% of these subjects are older than 60 years. The clinician is frequently faced with the need to decide which is the best therapeutic approach for these patients. While the origin of chronic diarrhea is diverse, impairment of intestinal barrier function, dysbiosis. and mucosal micro-inflammation are being increasingly recognized as underlying phenomena characterizing a variety of chronic diarrheal diseases. In addition to current pharmacological therapies, there is growing interest in alternative products such as mucoprotectants, which form a mucoadhesive film over the epithelium to reduce and protect against the development of altered intestinal permeability, dysbiosis, and mucosal micro-inflammation. This manuscript focuses on chronic diarrhea in adults, and we will review recent evidence on the ability of these natural compounds to improve symptoms associated with chronic diarrhea and to exert protective effects for the intestinal barrier