817 research outputs found

    Co-living, gentlemen's clubs, and residential hotels : a long view of shared housing infrastructures for single young professionals

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    Shared housing is an important infrastructure for young single professionals living and working in the city. Co-living is a contemporary shared housing infrastructure. But it certainly is not the first. We advocate for what Flanagan and Jacobs (2019) call taking a “long view” by drawing connections between early 19th-century gentlemen’s clubs, mid-19th-century residential hotels and contemporary co-living. We argue each have been dynamic infrastructures of mobility, work, and sociality that make certain practices more or less possible and reflect on how the socio-material form of these infrastructures connects with the infrastructural work it does. We draw on our own research study into co-living, connecting our findings with research on the historical housing types. Our findings show that shrinking private spaces, maximizing productive spaces, and integrating services are strategies that animate the infrastructural work of these housing types. By linking co-living with historical housing types, we demonstrate the importance of taking a “long view” when thinking infrastructurally about novel housing practices

    Employee Covenants Not to Compete: Where Does Virginia Stand?

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    Courts for some time now have been forced to deal with the validity of covenants not to compete as contained in employment contracts. Considered to be a restraint against trade, these covenants under common law were viewed with disfavor, if not hostility, both nationally and in the Commonwealth of Virginia, as being contrary to the American ideals of individual freedom, competition, and the free flow of commerce. As such they were seldom upheld. It was only after the courts recognized that employers had legitimate concerns and interests worthy of protections that reasonable covenants not to compete began to be enforced by injunction following a breach

    Selenomethionine and methyl selenocysteine: multiple-dose pharmacokinetics in selenium-replete men

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    According to the Nutritional Prevention of Cancer (NPC) trial, a selenized yeast supplement containing selenium, 200 mcg/day, decreased the incidence of total cancer, cancers of the prostate, colon and lung, and cancer mortality. The active agent in the selenized yeast supplement was assumed to be selenomethionine (SEMET), although the supplement had not been well speciated. The SELECT study, largely motivated by the NPC trial, enrolling nearly 40 times as many subjects, showed unequivocally that selenium 200 mcg/day, with selenium in the form of SEMET, does not protect selenium-replete men against prostate or other major cancer. The agent tested by SELECT, pure SEMET, could have been different from the selenized yeast tested in NPC. One of the selenium forms suspected of having chemopreventive effects, and which may have been present in the NPC agent, is methyl selenocysteine (MSC). This study, with 29 selenium-replete patients enrolled in a randomized, double-blind trial, compared the multiple-dose toxicity, pharmacokinetics and pharmacodynamics of MSC and SEMET. Patients were on trial for 84 days. No toxicity was observed. Although SEMET supplementation increased blood selenium concentration more than MSC did, neither form had a more than minimal impact on the two major selenoproteins: selenoprotein P(SEPP1) and glutathione peroxidase(GPX)

    Susceptibility testing of Haemophilus influenzae— an international collaborative study in quality assessment

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    In order to compare the prevalence of antibiotic resistance in different geographical areas, it is necessary to ensure that agreement is achieved between laboratories on the assignment of strains to ‘susceptible' and ‘resistant' categories. An international quality assessment study, involving 15 laboratories in eight countries, was performed to investigate the standard of performance of the susceptibility testing of Haemophilus influenzae. One hundred and fifty strains of H. influenzae were distributed from the London Hospital Medical College (LHMC) to all laboratories who were asked to test the susceptibility of the strains to ampicillin, chloramphenicol, tetracycline, trimethoprim, cephalosporins and ciprofloxacin. Laboratories were also asked to provide the details of methodology to test the susceptibility. Significant discrepancy between the LHMC and the participating laboratories appeared in the detection of resistance to ampicillin (especially ÎČ-lactamase-negative strains resistant to ampicillin) as well as the assignment of susceptibility and resistance to chloramphenicol, tetracycline and trimethoprim. Often these reflected the use of inappropriate breakpoints which led to erroneous assignment of susceptibility. Other variations including disc content, medium and supplement, inoculum as well as failure to measure zone sizes properly also led to some repeating anomalie
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