1,351 research outputs found
Study of the charge correlation function in one-dimensional Hubbard heterostructures
We study inhomogeneous one-dimensional Hubbard systems using the density
matrix renormalization group method. Different heterostructures are
investigated whose configuration is modeled varying parameters like the on-site
Coulomb potential and introducing local confining potentials. We investigate
their Luttinger liquid properties through the parameter K_rho, which
characterizes the decay of the density-density correlation function at large
distances. Our main goal is the investigation of possible realization of
engineered materials and the ability to manipulate physical properties by
choosing an appropriate spatial and/or chemical modulation.Comment: 6 pages, 7 figure
Biofuel policy for the pursuit of multiple goals: The case of Washington State
Agricultural and Food Policy, Resource /Energy Economics and Policy,
Preliminary estimates of tritium permeation and retention in the first wall of DEMO due to ion bombardment
Tritium self-sufficiency presents a critical engineering challenge for DEMO, requiring efficient breeding and extraction systems, as well as minimizing tritium losses to the surrounding systems, such as plasma-facing components, vacuum vessel, cooling system, etc. Structural and plasma-facing components will act as a tritium sink, as tritium will be accumulated in the bulk of these components due to energetic particle bombardment and may permeate out of the vacuum system. The design of the plasma-facing components will consequently directly influence the plant lifetime, operational safety and cost of any future power plant. Therefore, modeling of tritium retention and permeation in these components is required for the engineering designs of the tritium breeding and safety systems. In this work, the diffusion-transport code TESSIM-X is benchmarked against the well-established TMAP7 code and a comparison with a simplified DEMO-relevant test case is performed. The use of either code for modeling of DEMO conditions is discussed. Following this, TESSIM-X is used to provide a preliminary assessment of tritium permeation and retention in the DEMO first wall, based on the current WCLL (Water Cooled Lithium Lead) and HCPB (Helium Cooled Pebble Bed) breeding blanket designs
Investigating the melt pool properties and thermal effects of multi-laser diode area melting
Diode area melting (DAM) is a new additive manufacturing process that utilises customised architectural arrays of low-power
laser diode emitters for high-speed parallel processing of metallic feedstock. The laser diodes operate at shorter laser wavelengths
(808 nm) than conventional SLM fibre lasers (1064 nm) theoretically enabling more efficient energy absorption for specific
materials. This investigation presents the first work investigating the melt pool properties and thermal effects of the multi-laser
DAM process, modelling generated melt pools the unique thermal profiles created along a powder bed during processing. Using
this approach process, optimisation can be improved by analysing this thermal temperature distribution, targeting processing
conditions that induce full melting for variable powder layer thicknesses. In this work, the developed thermal model simulates the
DAM processing of 316L stainless steel and is validated with experimental trials. The simulation indicates that multi-laser DAM
methodology can reduce residual stress formation compared to the single point laser scanning methods used during selective laser
melting
Nonsymbiotic hemoglobins in rice are synthesized during germination and in differentiating cell types
Nonsymbiotic hemoglobins (ns-Hbs) previously have been found in monocots and dicots; however, very little is known about the tissue and cell type localization as well as the physiological function(s) of these oxygen-binding proteins. We report the immunodetection and immunolocalization of ns-Hbs in rice (Oryza sativa L.) by Western blotting and in situ confocal laser scanning techniques. Ns-Hbs were detected in soluble extracts of different tissues from the developing rice seedling by immunoblotting. Levels of ns-Hbs increased in the germinating seed for the first six days following imbibition and remained relatively constant thereafter. In contrast, ns-Hb levels decreased during leaf maturation. Roots and mesocotyls contained detectable, but low levels of ns-Hbs. Split-seed experiments revealed that ns-Hbs are synthesized de novo during seed germination and are expressed in the absence of any signal originating from the embryo. Immunolocalization of ns-Hbs by con- focal microscopy indicated the presence of ns-Hbs primarily in differentiated and differentiating cell types of the developing seedling, such as the aleurone, scutellum, root cap cells, sclerenchyma, and tracheary elements. To our knowledge, this is the first report of the specific cellular localization of these proteins during seedling development
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PPARα-targeted mitochondrial bioenergetics mediate repair of intestinal barriers at the host-microbe intersection during SIV infection.
Chronic gut inflammatory diseases are associated with disruption of intestinal epithelial barriers and impaired mucosal immunity. HIV-1 (HIV) causes depletion of mucosal CD4+ T cells early in infection and disruption of gut epithelium, resulting in chronic inflammation and immunodeficiency. Although antiretroviral therapy (ART) is effective in suppressing viral replication, it is incapable of restoring the "leaky gut," which poses an impediment for HIV cure efforts. Strategies are needed for rapid repair of the epithelium to protect intestinal microenvironments and immunity in inflamed gut. Using an in vivo nonhuman primate intestinal loop model of HIV/AIDS, we identified the pathogenic mechanism underlying sustained disruption of gut epithelium and explored rapid repair of gut epithelium at the intersection of microbial metabolism. Molecular, immunological, and metabolomic analyses revealed marked loss of peroxisomal proliferator-activated receptor-α (PPARα) signaling, predominant impairment of mitochondrial function, and epithelial disruption both in vivo and in vitro. To elucidate pathways regulating intestinal epithelial integrity, we introduced probiotic Lactobacillus plantarum into Simian immunodeficiency virus (SIV)-inflamed intestinal lumen. Rapid recovery of the epithelium occurred within 5 h of L. plantarum administration, independent of mucosal CD4+ T cell recovery, and in the absence of ART. This intestinal barrier repair was driven by L. plantarum-induced PPARα activation and restoration of mitochondrial structure and fatty acid β-oxidation. Our data highlight the critical role of PPARα at the intersection between microbial metabolism and epithelial repair in virally inflamed gut and as a potential mitochondrial target for restoring gut barriers in other infectious or gut inflammatory diseases
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