Ground-breaking: Scientific and sonic perceptions of environmental change in the African Sahel

Soils surrounding ancient settlements can hold evidence of the activities of past societies. To seek an understanding of how past societies have reacted and contributed to environmental change requires many data sources. The real-time audiovisual installation Ground-breaking problematises the presentation of such data gained through the image-analysis of soil materials. These data are used to connote environmental events and consequent human responses. Combining these data with audiovisual synthesis and environmental recordings, a basis for developing conceptualizations of new locales undergoing environmental change is presented; the visual and sonic narratives developed allowing the art-science interface to be explored

How analysts think: sense-making strategies in the analysis of temporal evolution and criminal network structures and activities

Analysis of criminal activity based on offenders’ social networks is an established procedure in intelligence analysis. The complexity of the data poses an obstacle for analysts to gauge network developments, e.g. detect emerging problems. Visualization is a powerful tool to achieve this, but it is essential to know how the analysts’ sense-making strategies can be supported most efficiently. Based on a think aloud study we identified ten cognitive strategies on a general level to be useful for designers. We also provide some examples how these strategies can be supported through appropriate visualizations

Lordship and Environmental Change in Central Highland Scotland c.1300–c.1400

Whilst there has been an increasing recognition of the infl uence of natural agency on human society in Scotland in the medieval period, conventional historiography has generally presented the wholesale reconfi guration of structures of secular lordship in the Scottish central Highlands in the 14th century as an essentially political consequence of the sociopolitical dislocation associated with the Anglo-Scottish wars that occurred after 1296. The establishment within the region of militarised Gaelic kindreds from the West Highlands and Hebrides of Scotland has come to be regarded as either a symptom of efforts by externally based regional lords to bolster their authority, or an opportunistic territorial aggrandisement by newly dominant neighbouring lords. Feuding and predatory raiding associated with these kindreds is recognised as competition for resources but generally in a context of projection of superior lordship over weaker neighbours. Evidence for long-term changes in climate extrapolated from North Atlantic proxy data, however, suggests that the cattle-based economy of Atlantic Scotland was experiencing protracted environmentally induced stress in the period c.1300–c.1350. Using this evidence, we discuss whether exchange systems operating within traditional lordship structures could offset localised and short-term pressures on the livestock-based regime, but could not be sustained long-term on the reduced fodder and contracting herd sizes caused by climatic deterioration. Territorial expansion and development of a predatory culture, it is argued, were responses to an environment-triggered economic crisis

Clinical disease course and survival outcomes following disease recurrence in adenoid cystic carcinoma with and without NOTCH signaling pathway activation.

BACKGROUND: Adenoid cystic carcinoma (ACC) is a rare salivary cancer. The highest rates of disease recurrence are in patients with NOTCH pathway activation, reported in up to 20%. Novel drugs targeting NOTCH signaling are under investigation in the recurrent/metastatic (R/M) setting. To understand their clinical utility, there is an urgent need to better characterize the disease course and outcomes following current standard of care treatment. METHODS: 120 patients with R/M ACC underwent clinical review at a single UK Cancer Centre. Patients were retrospectively assessed for tumor NOTCH pathway activation using next generation sequencing (NGS) targeting NOTCH1/2/3 genes and/or NOTCH1 intra-cellular domain (NICD1) immunohistochemistry. Demographic and treatment data were extracted from the clinical notes. Kaplan-Meier survival analysis was performed using log rank test. RESULTS: NOTCH pathway activation was identified in 13/120 patients (11 %). In 12/101 patients analyzed by NGS, NOTCH1/3 activating somatic mutations were identified, and a further patient was identified with NICD1 diffuse nuclear staining in whom NGS testing was not possible. Patients with NOTCH pathway activation had shorter median RFS (1.1 vs 3.4 years, p = 0.2032) and significantly reduced median OS from diagnosis (4.0 vs 16.3 years, p < 0.0001). There was significantly reduced median OS from time of disease recurrence/metastasis (1.9 vs 9.6 years, p < 0.0001). CONCLUSION: This study clearly demonstrates a reduction in OS from time of first confirmed disease recurrence/metastasis for patients with NOTCH pathway activated ACC. This provides support for developing new drugs for this sub-group of patients, for whom clinical outcomes are significantly worse and effective treatments are lacking

Charge and fluence lifetime measurements of a dc high voltage GaAs photogun at high average current

GaAs-based dc high voltage photoguns used at accelerators with extensive user programs must exhibit long photocathode operating lifetime. Achieving this goal represents a significant challenge for proposed high average current facilities that must operate at tens of milliamperes or more. This paper describes techniques to maintain good vacuum while delivering beam, and techniques that minimize the ill effects of ion bombardment, the dominant mechanism that reduces photocathode yield of a GaAs-based dc high voltage photogun. Experimental results presented here demonstrate enhanced lifetime at high beam currents by: (a) operating with the drive laser beam positioned away from the electrostatic center of the photocathode, (b) limiting the photocathode active area to eliminate photoemission from regions of the photocathode that do not support efficient beam delivery, (c) using a large drive laser beam to distribute ion damage over a larger area, and (d) by applying a relatively low bias voltage to the anode to repel ions created within the downstream beam line. A combination of these techniques provided the best total charge extracted lifetimes in excess of 1000 C at dc beam currents up to 9.5 mA, using green light illumination of bulk GaAs inside a 100 kV photogun

Tillage and phosphorus availability

Non-Peer Reviewe

Post-combustion carbon dioxide capture cost reduction to 2030 and beyond

Post-combustion CO2 capture (PCC) can be achieved using a variety of technologies. Importantly it is applicable to a wide range of processes and may also be retrofitted in certain cases. This paper covers the use of PCC for low carbon power generation from new natural gas combined cycle (NGCC) plants that are expected to be built in the UK in the 2020s and 2030s and that will run into the 2050s. Costs appear potentially comparable with other low carbon and controllable generation sources such as nuclear or renewables plus storage, especially with the lower gas prices that can be expected in a carbon-constrained world. Non-fuel cost reduction is still, however, desirable and, since CO2 capture is a new application, significant potential is likely to exist. For the NGCC+PCC examples shown in this paper, moving from ‘first of a kind’ (FOAK) to ‘nth of a kind’ (NOAK) gives significant improvements through both reduced financing costs and capital cost reductions. To achieve this the main emphasis needs to be on ‘commercial readiness’, rather than on system-level ‘technical readiness’, and on improvements through innovation activities, supported by underpinning research, that develop novel sub-processes; this will also maintain NOAK status for cost-effective financing. Feasible reductions in the energy penalty for PCC capture have much less impact, reflecting the inherently high levels of efficiency for modern NGCC+PCC plants

Photoinjector improvements at CEBAF in support of parity violation experiments

Three photoinjector modifications were undertaken at CEBAF to help ensure successful completion of the PREx and Qweak parity violation experiments: the development of a pockels cell high voltage switch that provides stable voltages at 960 Hz helicity flip rate with 60 μs rise/fall time, the installation of a two-Wien-filter spin flipper for slow spin reversal, and the installation of a new photogun with inverted insulator geometry that operates at higher bias voltage

Inverted Geometry Ceramic Insulators in High Voltage DC Electron Guns for Accelerators

A direct current (dc) high voltage photo-emission electron gun operating at 130 kV is utilized at the Jefferson Lab (JLab) Continuous Electron Beam Accelerator Facility to generate spin-polarized electrons for nuclear physics experiments. Over the past decade, JLab has tested and implemented inverted-geometry ceramic insulators in photoguns, connecting the cathode electrode in vacuum to the high voltage power supply using commercial high voltage cables. The results of those tests showed that breakdown voltage was increased using triple-point shielding electrodes and bulk-doped insulators that allow charge drainage. This contribution describes ongoing work to develop a robust insulatorcable connector for reliably applying 500 kV dc to a future polarized beam photogun operating at 350 kV without field emission