Socio-economic interest of treated wastewater reuse in agricultural irrigation and indirect potable water reuse: Clermont-Ferrand and Cannes case studies' cost-benefit analysis

International audienceUnlike many structuring projects, treated wastewater reuse projects are rarely subjected to economic analysis. And when they are, the social and environmental benefits and costs are often not accounted for or are not properly quantified. Here we show that the widely used cost-benefit analysis method showing the profitability of a project from the whole of the community's point of view can be adapted to treated wastewater reuse projects. The remaining evaluation difficulties are more due to the system's complexity rather than its methodological limits. Indeed, the operator must be able to understand, formalize and imagine constraints and risks associated with different domains such as urbanism, agriculture, climate, hydrology and trade. Remaining uncertainties over key parameter values can, however, be properly considered through scenarios and/or stochastic approaches. We illustrate the implementation of this methodological approach with two case studies: Clermont-Ferrand where treated wastewater is reused by a collective irrigation network; and Cannes where surface and groundwater recharge can enable indirect reuse for multiple purposes including indirect potable water production. These two French case studies highlight how economic analysis, dealing with uncertainties, can support decision making.Les projets de réutilisation des eaux usées traitées font rarement l’objet d’analyses économiques. Lorsque c’est le cas, les coûts et bénéfices sociaux et environnementaux ne sont pas correctement pris en compte ou quantifiés. Nous montrons ici que la méthodologie d’analyse coût–bénéfices (ACB) permettant d’évaluer la rentabilité d’un projet à l’échelle d’un territoire peut être adaptée à l’évaluation de projets de réutilisation des eaux usées traitées. La méthodologie employée est bien maitrisée et les difficultés de mise en oeuvre sont davantage liées à la complexité du système. L’opérateur doit en effet être en mesure de comprendre, de formaliser et d’imaginer les contraintes et les risques associés à différents domaines tels que l’urbanisme, l’agriculture et l’hydrologie. Les incertitudes résiduelles sur les valeurs de paramètres clés peuvent être prises en compte par l’étude de différents scénarios et/ou par des approches stochastiques. Nous illustrons cette approche à travers les études de cas français de Clermont-Ferrand où des eaux usées traitées sont réutilisées par un réseau collectif d’irrigation, et de Cannes où la recharge de milieux permet la réutilisation indirecte pour différents usages, dont la production indirecte d’eau potable. Ces études de cas illustrent comment l’analyse économique peut aider à la prise de décision

Integrative technology hubs for urban food- energy-water nexuses and cost-benefit-risk tradeoffs (I): Global trend and technology metrics

International audienceThe Food-Energy-Water (FEW) nexus for urban sustainability needs to be analyzed via an integrative rather than a sectoral or silo approach, reflecting the ongoing transition from separate infrastructure systems to an integrated social-ecological-infrastructure system. As technology hubs can provide food, energy, water resources via decentralized and/or centralized facilities, there is an acute need to optimize FEW infrastructures by considering cost-benefit-risk tradeoffs with respect to multiple sustainability indicators. This paper identifies, categorizes, and analyzes global trends with respect to contemporary FEW technology metrics that highlights the possible optimal integration of a broad spectrum of technology hubs for possible cost-benefit-risk tradeoffs. The challenges related to multiscale and multiagent modeling processes for the simulation of urban FEW systems were discussed with respect to the aspects of scaling-up, optimization process, and risk assessment. Our review reveals that this field is growing at a rapid pace and the previous selection of analytical methodologies, nexus criteria, and sustainability indicators largely depended on individual FEW nexus conditions disparately, and full-scale cost-benefit-risk tradeoffs were very rare. Therefore, the potential full-scale technology integration in three ongoing cases of urban FEW systems in Miami (the United States), Marseille (France), and Amsterdam (the Netherlands) were demonstrated in due purpose finally

The reuse of reclaimed water for irrigation around the Mediterranean Rim: a step towards a more virtuous cycle?

International audienceClimate change and a growing population around the Mediterranean Rim are increasing the need for water and, consequently, the pressure on resources in terms of both quantity and quality. High-quality water should be primarily reserved to drinking water while reclaimed water is an alternative for other usages. A review of situations in Tunisia, Jordan, France, and Italy involving the use of reclaimed water highlights the disparity in national regulations governing this alternative water resource and in its management. On the first hand, the use of recycled water for irrigation can have an adverse impact on public health and the environment, depending on treatment and irrigation practices. On the other hand, it may also represent a new source of water: wastewater should no longer be considered as waste but, rather, as a new resource to be handled in a circular economy-type loop. Current scientific knowledge in agronomic and environmental sciences, as well as in the economic and social sciences, can be integrated and used to lower the associated risk through the effective management of irrigation using recycled water and to address the following questions: (i) How can the time-varying nutrient needs of crops be managed to operate safe environmental reuse within an adapted risk assessment framework? (ii) What socio-economic models can render this integrated approach sustainable? (iii) What treatment systems and irrigation technology can be used to support these ideas and with what information? (iv) What changes in the regulations are needed

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

BackgroundWe previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15-20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants of life-threatening COVID-19 remain to be identified in similar to 80% of cases.MethodsWe report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening COVID-19, and 1373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Among the 928 patients tested for autoantibodies against type I IFN, a quarter (234) were positive and were excluded.ResultsNo gene reached genome-wide significance. Under a recessive model, the most significant gene with at-risk variants was TLR7, with an OR of 27.68 (95%CI 1.5-528.7, P=1.1x10(-4)) for biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR=3.70[95%CI 1.3-8.2], P=2.1x10(-4)). This enrichment was further strengthened by (1) adding the recently reported TYK2 and TLR7 COVID-19 loci, particularly under a recessive model (OR=19.65[95%CI 2.1-2635.4], P=3.4x10(-3)), and (2) considering as pLOF branchpoint variants with potentially strong impacts on splicing among the 15 loci (OR=4.40[9%CI 2.3-8.4], P=7.7x10(-8)). Finally, the patients with pLOF/bLOF variants at these 15 loci were significantly younger (mean age [SD]=43.3 [20.3] years) than the other patients (56.0 [17.3] years; P=1.68x10(-5)).ConclusionsRare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60 years old